Objective: Elf-1 is a member of the proto-oncogenes Ets-related transcription factor family and over-expressed in many human tumors, Ki-67 is an important nuclear antigen associated with cell proliferation. This study...Objective: Elf-1 is a member of the proto-oncogenes Ets-related transcription factor family and over-expressed in many human tumors, Ki-67 is an important nuclear antigen associated with cell proliferation. This study investigated the expression of Elf-1 and Ki-67 in non-small-cell lung cancer(NSCLC) and studied their correlation with the clinicopathological features. Methods: Tissue microarray from 64 cases lung cancer tissue and 10 cases normal lung tissue was constructed, immunohistochemical method was used to evaluate the protein expressions of Elf-1 and Ki-67, correlations of the expression of Elf-1 and Ki-67 to clinicopathological features of NSCLC were analyzed. Results: Expression of Elf-1 and Ki-67 in NSCLC tissues were significantly higher than in normal lung tissues(P < 0.05), the positive rate of Elf-1 and Ki-67 was 73.44% and 64.06% in NSCLC group, Overexpression of Elf-1 in NSCLC was significantly related to histopathological grading, different clinical staging and the intensity of ELF-1 expression was significantly higher in the group with lymph node metastasis than that without(P < 0.05). Overexpression of Ki-67 was also closely related to tumor differentiation, clinical stages and lymph node metastasis(P < 0.05). In addition positive correlation was found between the expressive intensity of Elf-1 and Ki-67(τ = 0.295, P = 0.018). Conclusion: The high expression and positive correlation of Elf-1 and Ki-67 in NSCLC suggest that they probably play a role in onset and progression of lung cancer, united detecting their expression could be used as an valuable molecular biological index for predicting the malignant behavior and early diagnosis of NSCLC.展开更多
According to the basic characteristics of the activities of summer monsoon in the South China Sea, a standardized index, sI, has been designed that integrates a dynamic factor (southwesterly component) and a thermodyn...According to the basic characteristics of the activities of summer monsoon in the South China Sea, a standardized index, sI, has been designed that integrates a dynamic factor (southwesterly component) and a thermodynamic factor (OLR) for the indication of summer monsoon in the South China Sea. With the index determined for individual months of June, July and August and the entire summertime from 1975 to 1999, specific months and years are indicated that are either strong or weak in monsoon intensity. The variation is studied for the patterns and sI抯 relationship is revealed with the onset of summer monsoon and the precipitation in Guangdong province and China. The results show that there are quasi-10 and quasi-3-4 year cycles in the interannual variation of the monsoon over the past 25 years. When it has an early (late) onset, the summer monsoon is usually strong (weak). In the strong (weak) monsoon years, precipitation tends to be more (less) in the first raining season of the year but normal or less (normal) in the second, in the province, but it would be more (less) in northeastern China and most parts of the northern China and south of the lower reaches of the Changjiang River and less (more) in the middle and lower reaches of the river, western part of northern China and western China.展开更多
基金Supported by grants from the Science and Technology Development Project of Yantai(No.2008162)Natural Sciences Foundation of Shandong(No.ZR2013HL004)Science and Technology Important Project of Binzhou Medical College(No.BY20bkjzd04)
文摘Objective: Elf-1 is a member of the proto-oncogenes Ets-related transcription factor family and over-expressed in many human tumors, Ki-67 is an important nuclear antigen associated with cell proliferation. This study investigated the expression of Elf-1 and Ki-67 in non-small-cell lung cancer(NSCLC) and studied their correlation with the clinicopathological features. Methods: Tissue microarray from 64 cases lung cancer tissue and 10 cases normal lung tissue was constructed, immunohistochemical method was used to evaluate the protein expressions of Elf-1 and Ki-67, correlations of the expression of Elf-1 and Ki-67 to clinicopathological features of NSCLC were analyzed. Results: Expression of Elf-1 and Ki-67 in NSCLC tissues were significantly higher than in normal lung tissues(P < 0.05), the positive rate of Elf-1 and Ki-67 was 73.44% and 64.06% in NSCLC group, Overexpression of Elf-1 in NSCLC was significantly related to histopathological grading, different clinical staging and the intensity of ELF-1 expression was significantly higher in the group with lymph node metastasis than that without(P < 0.05). Overexpression of Ki-67 was also closely related to tumor differentiation, clinical stages and lymph node metastasis(P < 0.05). In addition positive correlation was found between the expressive intensity of Elf-1 and Ki-67(τ = 0.295, P = 0.018). Conclusion: The high expression and positive correlation of Elf-1 and Ki-67 in NSCLC suggest that they probably play a role in onset and progression of lung cancer, united detecting their expression could be used as an valuable molecular biological index for predicting the malignant behavior and early diagnosis of NSCLC.
基金 Research on the Formation Mechanism and Prediction Theory of Severe Climate Disasters in China (G1998040900(I))
文摘According to the basic characteristics of the activities of summer monsoon in the South China Sea, a standardized index, sI, has been designed that integrates a dynamic factor (southwesterly component) and a thermodynamic factor (OLR) for the indication of summer monsoon in the South China Sea. With the index determined for individual months of June, July and August and the entire summertime from 1975 to 1999, specific months and years are indicated that are either strong or weak in monsoon intensity. The variation is studied for the patterns and sI抯 relationship is revealed with the onset of summer monsoon and the precipitation in Guangdong province and China. The results show that there are quasi-10 and quasi-3-4 year cycles in the interannual variation of the monsoon over the past 25 years. When it has an early (late) onset, the summer monsoon is usually strong (weak). In the strong (weak) monsoon years, precipitation tends to be more (less) in the first raining season of the year but normal or less (normal) in the second, in the province, but it would be more (less) in northeastern China and most parts of the northern China and south of the lower reaches of the Changjiang River and less (more) in the middle and lower reaches of the river, western part of northern China and western China.
