AIM： To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 （Bmi-1） expression and the clinicopathological features of gastric carcinoma （GC）.METHODS： Immunohistochemistry...AIM： To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 （Bmi-1） expression and the clinicopathological features of gastric carcinoma （GC）.METHODS： Immunohistochemistry was used to detect the expression of Bmi-1 and ki-67. Doublelabeling staining was used to display the distribution of Bcl-2^＋/ki-67 cells in 162 cases of GC and its matched normal mucosa and precancerous lesion.RESULTS： The positive rate of Bmi-1 expression in GC（52.5%） was significantly higher than that in normal gastric mucosa （21.6%, X^2 = 33.088, P 〈 0.05）. The Bmi-1 expression in GC was closely related with the Lauren＇s and Borrmann＇s classification and clinicalstage （X^2 = 4.400, 6.122 and 11.190, respectively, P〈 0.05）. The expression of ki-67 was related to the Borrmann＇s classification （X^2 = 13.380, P 〈 0.05）.Bcl-2 expression was correlated with the Lauren＇s classification （Z2 = 4.725, P 〈 0.05）, and the Bmi-1 expression both in GC （rk = 0.157, P 〈 0.05） and inintestinal metaplasia （rk = 0.270, P 〈 0.05）.CONCLUSION： Abnormal Bmi-1 expression in GCmay be involved in cell proliferation, apoptosis andcancerization. This marker can objectively indicate theclinicopathological characteristics of GC.展开更多
Insoluble microparticles in ice cores are related closely to the transportation of eolian dust,and thus are important natural media to reconstruct climate change.In this study,we conducted a systematic mineral-magneti...Insoluble microparticles in ice cores are related closely to the transportation of eolian dust,and thus are important natural media to reconstruct climate change.In this study,we conducted a systematic mineral-magnetic investigation of insoluble microparticles in the Nojingkangsang ice core (29°2.1'N,90°11.88'E,5950 m) from the Southern Tibetan Plateau.Results indicate that the dominant magnetic mineral is magnetite,and its concentration has grown significantly since the 1980s,which coincides with trends in climate warming of the Tibetan Plateau.Influenced by regional warming,the glacial recession around Nojingkangsang shortens the distance between the dust source and glacial areas and thus increases the concentration of coarse-grained magnetic minerals in ice cores.However,the frequency of dust storms,associated with annual precipitation,could play only a regulatory role on the magnetic content over yearly (or seasonal) time scales.Therefore,using a new approach,the magnetic index of insoluble microparticles in ice cores of this region is seen as mainly reflecting trends in climate warming.展开更多
文摘it评价型式作为学术论文作者表达态度意义的重要手段,已成为应用语言学的重要研究话题。本文基于大型可比学术英语语料库,对中西学者学术论文中特征性it评价型式及其特征性意义进行对比分析。研究表明,两组学者共享4个特征性it型式:it v-link ADJ to和it v-link ADJ that型式在两组文本中皆最为高频,it v-link ADJ for n to和it v-link ADJ wh-次之。但是,除it v-link ADJ for n to外,中国学者的it型式使用频数显著低于西方学者。两个群体的it型式表达了大致相似的特征性意义,然而具体的语义分布差异明显。中国学者趋于表达命题或事件的难易度和确定性意义,而西方学者趋于表达重要性和似然性意义。本文还讨论了与此相关的认识论、二语知识、语用能力等问题,以及对二语学术写作和学术话语分析的启示。
基金Supported by A special fund for Key University Laboratories from Department of Education of Liaoning Province, No. 2008S233
文摘AIM： To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 （Bmi-1） expression and the clinicopathological features of gastric carcinoma （GC）.METHODS： Immunohistochemistry was used to detect the expression of Bmi-1 and ki-67. Doublelabeling staining was used to display the distribution of Bcl-2^＋/ki-67 cells in 162 cases of GC and its matched normal mucosa and precancerous lesion.RESULTS： The positive rate of Bmi-1 expression in GC（52.5%） was significantly higher than that in normal gastric mucosa （21.6%, X^2 = 33.088, P 〈 0.05）. The Bmi-1 expression in GC was closely related with the Lauren＇s and Borrmann＇s classification and clinicalstage （X^2 = 4.400, 6.122 and 11.190, respectively, P〈 0.05）. The expression of ki-67 was related to the Borrmann＇s classification （X^2 = 13.380, P 〈 0.05）.Bcl-2 expression was correlated with the Lauren＇s classification （Z2 = 4.725, P 〈 0.05）, and the Bmi-1 expression both in GC （rk = 0.157, P 〈 0.05） and inintestinal metaplasia （rk = 0.270, P 〈 0.05）.CONCLUSION： Abnormal Bmi-1 expression in GCmay be involved in cell proliferation, apoptosis andcancerization. This marker can objectively indicate theclinicopathological characteristics of GC.
基金supported by National Natural Science Foundation of China (Grants Nos. 40874033,40974036,41074041 and 41025013)CAS/SAFEA International Partnership Program for Creative Research Teams
文摘Insoluble microparticles in ice cores are related closely to the transportation of eolian dust,and thus are important natural media to reconstruct climate change.In this study,we conducted a systematic mineral-magnetic investigation of insoluble microparticles in the Nojingkangsang ice core (29°2.1'N,90°11.88'E,5950 m) from the Southern Tibetan Plateau.Results indicate that the dominant magnetic mineral is magnetite,and its concentration has grown significantly since the 1980s,which coincides with trends in climate warming of the Tibetan Plateau.Influenced by regional warming,the glacial recession around Nojingkangsang shortens the distance between the dust source and glacial areas and thus increases the concentration of coarse-grained magnetic minerals in ice cores.However,the frequency of dust storms,associated with annual precipitation,could play only a regulatory role on the magnetic content over yearly (or seasonal) time scales.Therefore,using a new approach,the magnetic index of insoluble microparticles in ice cores of this region is seen as mainly reflecting trends in climate warming.
