状医药线点炙治疗小儿厌食157例

药线点灸疗法是流传于广西壮族民间的一种医疗方法。自1987年以来,我们采用此法治疗小儿厌食157例,获得较好疗效,现报道如下。 1 一般资料 157例中。门诊病例69例,普查病例88例,其中男性80例,女性77例。年龄最大7岁,最小6个月。病程最长5年,最短1个月。伴自汗,盗汗者58例。 2 治疗方法 2.1 取穴:不论是脾运失健。

外治疗法治疗妊娠期带状疱疹病毒性睑皮炎临床观察

目的观察外治疗法治疗妊娠期带状疱疹病毒性睑皮炎的临床疗效。方法 20例妊娠期带状疱疹病毒性睑皮炎患者分别采用壮医药线点灸病变部位1~10次,熊胆溶液湿敷或外涂病变部位7~10次,双耳尖放血1~3次治疗。结果治愈17例,好转3例,无效0例,治愈率为92.5%。结论运用外治疗法治疗妊娠期带状疱疹病毒性睑皮炎疗效较好,且对胎儿无不利影响。

LOCALIZATION OF OBJECT (SPINE) IN MEDICAL IMAGE USING ACTIVE SHAPE MODELS

Active shape models (ASM), consisting of a shape model and a local gray-level appearance model, can be used to locate the objects in images. In original ASM scheme, the model of object′s gray-level variations is based on the assumption of one-dimensional sampling and searching method. In this work a new way to model the gray-level appearance of the objects is explored, using a two-dimensional sampling and searching technique in a rectangular area around each landmark of object shape. The ASM based on this improvement is compared with the original ASM on an identical medical image set for task of spine localization. Experiments demonstrate that the method produces significantly fast, effective, accurate results for spine localization in medical images.

Ocular drug delivery systems:An overview

The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration,especially for the treatment of anterior segment diseases. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal,dynamic and static ocular barriers. Also,therapeutic drug levels are not maintained for longer duration in target tissues. In the past two decades,ocular drug delivery research acceleratedly advanced towards developing a novel,safe and patient compliant formulation and drug delivery devices/techniques,which may surpass these barriers and maintain drug levels in tissues. Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also,it includes development of conventional topical formulations such as suspensions,emulsions and ointments. Various nanoformulations have also been introduced for anterior segment ocular drug delivery. On the other hand,for posterior ocular delivery,research has been immensely focused towards development of drug releasing devices and nanoformulations for treating chronic vitreo-retinal diseases. These novel devices and/or formulations may help to surpass ocular barriers and associated side effects with conventional topicaldrops. Also,these novel devices and/or formulations are easy to formulate,no/negligibly irritating,possess high precorneal residence time,sustain the drug release,and enhance ocular bioavailability of therapeutics. An update of current research advancement in ocular drug delivery necessitates and helps drug delivery scientists to modulate their think process and develop novel and safe drug delivery strategies. Current review intends to summarize the existing conventional formulations for ocular delivery and their advancements followed by current nanotechnology based formulation developments. Also,recent developments with other ocular drug delivery strategies employing in situ gels,implants,contact lens and microneedles have been discussed.

Liver resection for benign hepatic lesions:A retrospective analysis of 827 consecutive cases

AIM:To analyze the operative and perioperative factors associated with hepatectomy of benign hepatic lesions.METHODS:A total of 827 condecutive cases of benign hepatic lesion undergoing hepatectomy from January 1986 to December 2005 in the Chinese PLA General Hospital were investigated retrospectively according to their medical documentation.RESULTS:The effect of operative and perioperative factors on the outcome of patients were analyzed.Of the 827 cases undergoing hepatectomy for more than 3 liver segments accounted for 22.1%,316(38.21%) required transfusion of blood products during operation.The average operating time was 220.59 ± 109.13 min,the average hospital stay after operation was 13.55 ± 9.38 d.Child-Pugh A accounted for 98.13%.The postoperative complication rate was 13.54% and the in-hospital mortality rate was 0.24%.Multivariate analysis showed that operating time(P = 0.004,OR = 1.003) and albumin value(P = 0.040,OR = 0.938) were the independent predictors of morbidity and indicated that operating time,blood transfusion,complication rate,and LOS had a trend to decrease.CONCLUSION:Hepatectomy for benign hepatic lesions can be performed safely with a low morbidity and mortality,provided that it is carried out with optimized perioperative management and an innovative surgical technique.

Welding of shape memory alloy to stainless steel for medical occluder

Dissimilar metal joining between NiTi shape memory alloy（SMA） and stainless steel was conducted.A cluster of NiTi SMA wires were first joined with tungsten inert gas（TIG） welding process,then the NiTi SMA TIG weld was welded to a stainless steel pipe with laser spot welding process.The microstructure of the welds was examined with an optical microscope and the elemental distribution in the welds was measured by electron probe microanalysis（EPMA）.The results show that TiC compounds dispersively distribute in the NiTi SMA TIG weld.However,the amount of TiC compounds greatly decreases around the fusion boundary of the laser spot weld between the NiTi SMA and stainless steel.Mutual diffusion between NiTi shape memory alloy and stainless steel happen within a short distance near the fusion boundary,and intermetallic compounds such as Ni3Ti＋（Fe,Ni）Ti appear around the fusion boundary.

Frequent office visits of patients with chronic kidney disease: Is a prelude to prevention of dialysis

This study is an excerpt of broad-based offce practice which is designed to treat patients with diabetes and hypertension, the two most common causes of chronic kidney disease （CKD）, as well as CKD of unknown etiology. This model of offce practice is dedicated to evaluating patients with CKD for their complete well-being; blood pressure control, fuid control and main-tenance of acid-base status and hemoglobin. Frequent offce visits, every four to six weeks, confer a healthy life style year after year associated with a feeling of good well-being and a positive outlook. Having gained that, such patients remain compliant to their medica-tion and diet, and scheduled laboratory and offce vis-its which are determinant of a dialysis-free life.

Hepatitis B in China: from Guideline to Practice

Chronic hepatitis B infection is a very important health problem in China, which is carrying an enormous economic and social burdens. The major routs of chronic hepatitis B infection in China are mother-infant vertical transmission and early childhood horizontal transmission. After more than 10 years implementation of universal vaccination against hepatitis B in newborns and safety injection in health care settings, the prevalence of HBsAg in general population has decreased from 9.75% to around 7%. In China, patients with hepatitis are cared by either hepatologists or physicians of infectious diseases. The Chinese Society of Hepatology, and Chinese Society of Infectious Diseases jointly issued an evidence-based guideline on the prevention and treatment of chronic hepatitis B in 2005. This guideline concisely describes the virology, epidemiology, natural history and prevention, as well as diagnosis and management of chronic hepatitis B. It also highlights the importance of active viral replication in disease progression in chronic HBV infection and explicitly states the necessity of antiviral therapy in patient care. The cornerstone of anti-hepatitis B therapy is optimal use of interferons or nucleos(t)ide analogs in those patients with active viral replication and elevated serum transaminase levels. Through an independent continue medical educational agency, a panel of selected speakers were trained to give well-formatted talks on the key points of the guideline in over 60 major cities across China. This educational campaign among health care providers has greatly improved the awareness and the stand of care for antiviral therapy.

Significance of Bcl-xL in human colon carcinoma

AIM:To investigate the clinical significance of Bcl-xL gene in the pathogenesis of human colon carcinoma. METHODS:Fifty-six pair tissue samples from patients with colon cancer were collected, and protein level of the Bcl-xL gene was measured by immunohistochemistry method. The correlation of Bcl-xL expression with clinical index was evaluated. After human colon cancer cell line HT29 was transfected with Bcl-xL small interfering RNA (siRNA), the anchorage-independent growth of cancer cells was detected by colony formation in soft agar and invasion ability of cancer cells was determined by a transwell model. RESULTS:The Bcl-xL expression was higher in cancerous tissue samples than in normal tissue samples (38.78 ± 11.36 vs 0.89 ± 0.35, P < 0.001), and was associated with the pathological grade, lymphnode metastasis and Duke’s stage of colorectal carcinoma. Transfection with Bcl-xL siRNA inhibited the colony formation and invasion ability of human colon cancer cell line HT29 in vitro. CONCLUSION:Bcl-xL gene plays an important role in carcinogenesis of human colorectal carcinoma and is associated with malignant biological behaviors of human colorectal carcinoma.

The effect of digital health technologies on managing symptoms across pediatric cancer continuum:A systematic review

Objective:Pediatric cancer patients endure multiple symptoms during treatment and also in survivorship.Digital health technologies provide an innovative way to support their symptom management.This review aimed to examine the effect of digital health technologies on managing symptoms among across pediatric cancer continuum.Methods:A systematic literature search of six English and three Chinese electronic databases was combined with hand searching,to identify eligible research studies from database establishment to November 30,2019.Two reviewers carried out data selection,data extraction,and quality appraisal independently.A narrative approach was taken to summarize data.Results:Four randomized control trials,two quasi-experiments,and five one group pre-posttest designed studies,were included in the review with a total of 425 participants.The methodological quality of the studies was generally fair.Seven symptoms(anxiety,depression,pain,anger,fatigue,fear,distress)and seven digital health technologies(visual reality,website,humanoid robot,app,wearable devices,short messages and videoconference)were reported in the included studies.Conclusions:Current evidence supports the effect of digital health technologies is generally mixed and inconclusive.There is a trend of positive effects found in the interventions that feature digital health technologies’interactive function.This review highlights the need for further investigation with rigorous research designs and the consideration of influencing factors from the symptoms,participants,and context levels to inform a better digital health implementation.

Why do we have so much trouble treating anal fistula?

Anal fistula is among the most common illnesses affecting man.Medical literature dating back to 400 BC has discussed this problem.Various causative factors have been proposed throughout the centuries,but it appears that the majority of fistulas unrelated to specific causes (e.g.Tuberculosis,Crohn’s disease) result from infection (abscess) in anal glands extending from the intersphincteric plane to various anorectal spaces.The tubular structure of an anal fistula easily yields itself to division or unroofing (fistulotomy) or excision (fistulectomy) in most cases.The problem with this single,yet effective,treatment plan is that depending on the thickness of sphincter muscle the fistula transgresses,the patient will have varying degrees of fecal incontinence from minor to total.In an attempt to preserve continence,various procedures have been proposed to deal with the fistulas.These include: (1) simple drainage (Seton);(2) closure of fistula tract using fibrin sealant or anal fistula plug;(3) closure of primary opening using endorectal or dermal flaps,and more recently;and (4) ligation of intersphincteric fistula tract (LIFT).In most complex cases (i.e.Crohn’s disease),a proximal fecal diversion offers a measure of symptom-atic relief.The fact remains that an "ideal" procedure for anal fistula remains elusive.The failure of each sphincter-preserving procedure (30%-50% recurrence) often results in multiple operations.In essence,the price of preservation of continence at all cost is multiple and often different operations,prolonged disability and disappointment for the patient and the surgeon.Nevertheless,the surgeon treating anal fistulas on an occasional basis should never hesitate in referring the patient to a specialist.Conversely,an expert colorectal surgeon must be familiar with many different operations in order to selectively tailor an operation to the individual patient.

Penetrating ectopic peptic ulcer in the absence of Meckel's diverticulum ultimately presenting as small bowel obstruction

We report here how a heterotopic penetrating peptic ulcer progressed to cause small bowel obstruction in a pa- tient with multiple previous negative investigations. The clinical presentation, radiographic features and patho- logical findings of this case are described, along with the salient lessons learnt. The added value of wireless cap- sule endoscopy （WCE） in such circumstances is debated.

Abstraction of Data Elements of Clinical Symptoms in Chinese Medicine

This report analyzes the existing problems in terminology referring to clinical symptoms of traditional Chinese medicine(TCM)from the viewpoint of data sharing and elaborates the necessity of establishing a standard directory of clinical data elements of TCM.We evaluated the principles and methods of data element extraction according to the status quo of the clinical information system and characteristics of symptoms for TCM and consequently proposed a three-layer model for optimal extraction.

Supplementary tests for confirmation of brain death

In 1959, the concept of brain death （BD） or irreversible coma was described by Mollaret and Goulon （1959）. The first guideline （the Harvard criteria） for deciding BD was established in 1968 （Ad Hoc Committee of the Harvard Medical School, 1968）. This concept has been accepted worldwide although its fundamental meaning is not exactly globally uniform yet. Some countries （e.g., the US） view BD as ＂whole brain death＂, while others （e.g., the UK） as brain-stem death. The guidelines for the diagnosis of BD also differ among countries, even among hospitals in the same country.

Factors related to diabetes mellitus： Study on diabetes patients at HUSM, Kelantan

A study was conducted to identify the factors related to diabetes mellitus among the diabetes patients at HUSM Kelantan. A total of 972 diabetes mellitus patients who had attended Hospital Universiti Sains Malaysia （HUSM） from 2005 to 2006 were involved in the study. The significant findings include： （1） Mean age of diabetes patients under the study was 44.36 years old; （2） The average age of patients from control group and pre-diabetes group which came from the middle-age were 44.30 and 42.43 years old respectively. Patients from diabetes group had recorded the highest mean age of 53.24 years old which are the elderly; （3） There was a significant difference in the average blood sugar between patient age group of〈30 years old and patient age group of〉30 years old. However, there was no significant difference in the mean blood sugar between male and female patients; （4） There were significant associations between diabetes mellitus and gender, occupation and clinical symptoms such as tired, polyuria and polydipsia. However, there was no significant association between diabetes mellitus and polyphagia symptoms. The authors believed that the symptoms ofpolyuria and polydipsia were highly associated with the chances of the patients to get diabetes mellitus.

The Present Situation of TCM Treatment for Diabetes and its Researches

Diabetes is a frequently encountered disease. There are now approximately 40 million diabetes patients in China1, most of them with diabetes II.

An investigation on traditional Chinese medicine in Dublin Ireland

The traditional Chinese medicine chain arrived in Ireland in 2005. This study focused on the standardization and adaptation of TCM companies and the customer profile in Irish market. The objective of this research dissertation is to find that how TCM is learned in Irish market and how it faces different cultures.

MR Request Procedures from Chinese Medical Facility vs That from US Medical Facility

A comparison of how MR released to the insurance company Assist Card from a Chinese medical facility Hengyang HP vs from a US facility Stutter Health was roughly displayed. The former MR was for Mafia, a Colombian Assist Card cardholder, worked and got hospitalized in China, the later MR for Kong Lijun, a Chinese StarrChina cardholder, visited and got medical treatments in USA, they shared Assist Card international traveling and insurance assistance. In both cases, Assist Card got MR for the patient from the facilities that gave them treatments. As a third party, Assist Card went through different procedures to claim MR from Hengyang HP vs from Stutter Health. It managed to have got three MRs and three FTF and was pushing a fourth MR from Hengyang HP in about ten days, while it got only one MR from Stutter Health in ten days after twists and turns. The over cooperative or obedient tendency toward Assist Card＇s requests made Hengyang HP vulnerable and controllable, while the strict MR release procedures in Stutter Health made Assist Card passive and helpless.

Thoughts on Promoting TCM Intercultural Communication in UK

Due to the differences in culture and system and the influence of migration policy, etc., the spread of TCM in UK faces lots of difficulties. Therefore, to promote the TCM intercultural communication, we need to enhance the publicity of TCM cultural tastes, to strengthen the construction of TCM education system in addition to making full use of Chinese students in UK.

New challenges of geriatric cardiology： from clinical to preclinical research

The field of geriatric cardiology reflects the evolving medical approaches tailored to address the needs of the growing population of oldest old with cardiovascular diseases （CVD）. The burden of CVD is expected to increase particularly for the most common types of chronic heart disease of the elderly including coronary artery disease, heart failure and atrial fibrillation. In this context of dramatic demographic changes, geriatric cardiologists are facing important challenges. In this review, we outline the basic concepts of geriatric cardiology and describe these challenges as well as the unmet needs around this discipline with also a focus on the translation from basic research.