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吗啡急性成瘾猫模型的建立 被引量:6
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作者 郭韬 杜亚丽 +1 位作者 张素芳 陈晓刚 《脑与神经疾病杂志》 2008年第6期711-712,共2页
目的:探讨及研究建立急性吗啡成瘾猫模型的方法。方法:将12只猫随机分成实验组和对照组,实验组9只,对照组3只。实验组按逐日递增原则,分别于每日8点、12点、16点行背部皮下注射盐酸吗啡。第一天吗啡单次用量5mg·kg-1,之后分别为10m... 目的:探讨及研究建立急性吗啡成瘾猫模型的方法。方法:将12只猫随机分成实验组和对照组,实验组9只,对照组3只。实验组按逐日递增原则,分别于每日8点、12点、16点行背部皮下注射盐酸吗啡。第一天吗啡单次用量5mg·kg-1,之后分别为10mg·kg-1、15mg·kg-1、20mg·kg-1、25mg·kg-1。连续5天给药。第6天实验组以0.5mg·kg-1纳洛酮诱发戒断症状。比较实验组和对照组猫的戒断症状。结果:实验组纳络酮诱发戒断症状与对照组的比较,经统计学处理显示组间差异很显著。结论:急性吗啡成瘾猫模型的建立是切实可行的。 展开更多
关键词 吗啡急性成瘾 猫模型 戒断
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适于磁共振功能成像研究的急性癫痫猫模型的建立
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作者 黄劲柏 徐海波 +1 位作者 孔庆霞 孙圣刚 《上海医学影像》 2007年第1期61-62,75,共3页
目的建立适于脑功能研究的急性癫痫动物模型。方法家猫10只,随机分为两组,实验组肌注戊四氮(PTZ)55mg/kg后观察其行为表现,进行脑电图检查,并分别于癫痫发作前1h,发作后1h、1d、3d、5d、7d行MRI检查。对照组肌注等量生理盐水。结果实验... 目的建立适于脑功能研究的急性癫痫动物模型。方法家猫10只,随机分为两组,实验组肌注戊四氮(PTZ)55mg/kg后观察其行为表现,进行脑电图检查,并分别于癫痫发作前1h,发作后1h、1d、3d、5d、7d行MRI检查。对照组肌注等量生理盐水。结果实验组均于注射PTZ后1~5min出现肢体节律性抽动及全身阵挛,脑电图显示有特征性尖波、棘波、棘波群,MR上均无明显异常发现。对照组无异常行为及心电图变化。结论该急性模型建立快,成功率高,有良好的可预测性和可重复性,无明显脑结构性异常,是进行脑功能研究的理想模型。 展开更多
关键词 癫痫 猫模型 磁共振功能成像 脑电图
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HIV动物模型在毒品滥用研究中的应用
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作者 王婵 杨根梦 +5 位作者 刘柳 王浩伟 苗霖 李怡 李娟 曾晓锋 《中国实验动物学报》 CAS CSCD 北大核心 2023年第5期653-659,共7页
目前,毒品滥用及人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染的共病问题备受关注。毒品滥用是HIV传播的促发因素之一,其同样可加重HIV感染者中枢神经系统的病毒载量水平和加速HIV相关神经认知障碍(HIV-associated neurocog... 目前,毒品滥用及人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染的共病问题备受关注。毒品滥用是HIV传播的促发因素之一,其同样可加重HIV感染者中枢神经系统的病毒载量水平和加速HIV相关神经认知障碍(HIV-associated neurocognitive disorders,HAND)的疾病进展速度。本文着重介绍了目前常用的HIV感染相关动物模型,如非人灵长类动物、啮齿类动物及猫科动物,分析了其局限性和优势性,并对HIV感染相关动物模型在毒品滥用研究中的应用进行了综述。 展开更多
关键词 人类免疫缺陷病毒 毒品滥用 非人灵长类动物模型 HIV感染相关啮齿类动物模型 FIV/家动物模型
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Levodopa methyl ester increases nerve growth factor expression in visual cortex area 17 in a feline model of strabismic amblyopia
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作者 Yongwen Li Xing Lin Shijun Zhang Rong Li Weizhe Jiang Renbin Huang 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第26期2026-2031,共6页
In the present study, a feline model of strabismic amblyopia was established during a sensitive developmental period, and the influence of levodopa methyl ester and levodopa on nerve growth factor expression in the vi... In the present study, a feline model of strabismic amblyopia was established during a sensitive developmental period, and the influence of levodopa methyl ester and levodopa on nerve growth factor expression in the visual cortex (area 17) was compared. Pattern visual-evoked potential and immunohistochemistry results showed that levodopa methyl ester and levodopa treatment shortened P10o wave latency, increased Pleo amplitude, and increased the number of endogenous nerve growth factor-positive cells in visual cortex levels. In particular, the effects of levodopa methyl ester were superior to levodopa treatment. 展开更多
关键词 levodopa methyl ester nerve growth factor strabismic amblyopia visual cortex neural regeneration
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Local predation pressure predicts the strength of mobbing responses in tropical birds 被引量:4
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作者 Luis SANDOVAL David R.WILSON 《Current Zoology》 SCIE CAS CSCD 2012年第5期781-790,共10页
Many birds join cooperative mobbing aggregations and collectively harass predators. Individuals participating in these ephemeral associations benefit by deterring the predator, but also incur energetic costs and incre... Many birds join cooperative mobbing aggregations and collectively harass predators. Individuals participating in these ephemeral associations benefit by deterring the predator, but also incur energetic costs and increased risk of predation. Ex- plaining the evolution of mobbing is challenging because individuals could prevail by selfishly seeking safety while allowing others to mob. An important step in understanding the evolution of mobbing is to identify factors affecting its expression. The ecological constraints model suggests that animals are more likely to cooperate under adverse environmental conditions, such as when local predation pressure is high. We tested this prediction by comparing the mobbing responses of several species of birds to the local abundance of their primary predator, the ferruginous pygmy-owl Glaucidium brasilianum. We used acoustic playback to elicit mobbing responses in environments where owls were common, uncommon, or rare. Stimuli were either the song of a fer- ruginous pygmy-owl or the mobbing calls of three of the owl's common prey species. During each playback, we characterized mobbing responses by noting the number of species and individuals that approached the loudspeaker, as well as the closest ap- proach by any bird. Mobbing responses to both stimuli were strong in locations where Ferruginous Pygmy-owls were common, intermediate where owls were uncommon, and weak where they were rare. This pattern persisted even after controlling for dif- ferences in species richness and composition among the three environments. Results support the ecological constraints model and provide strong evidence that intense predation pressure increases the expression of cooperative mobbing in tropical birds [Cur- rent Zoology 58 (5): 781-790, 2012]. 展开更多
关键词 Antipredator behavior Alarm signal Cooperative defense Learning MOBBING Tropical bird
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