By using the laser-monitoring technique,solid-liquid equilibrium data of glutaric acid in cyclohexanol,cyclohexanone,their five mixed solvents and acetic acid were measured within the temperature range from 292.15K to...By using the laser-monitoring technique,solid-liquid equilibrium data of glutaric acid in cyclohexanol,cyclohexanone,their five mixed solvents and acetic acid were measured within the temperature range from 292.15K to 354.60K by dynamic method.Empirical formula and λh equation were used to correlate the solubilities of glutaric acid in eight solvents.The maximal average relative deviations were 1.15% and 2.20% by using the em-pirical formula and λh equation to correlate the solubility data.The results showed that the empirical formula and λh model could correlate the solubility data of glutaric acid in eight solvents.In addition,the solubility data of glutaric acid in five mixtures(cyclohexanone+cyclohexanol)could be predicted with the NRTL equation utilizing the pa-rameters of the binary systems.The total average relative deviation was 3.60%.The results indicate that the NRTL equation could well predict the solubilities of glutaric acid in the mixed solvents of cyclohexanone and cyclohexanol.展开更多
Cyproterone acetate (CPA) is a steroidal synthetic progestagen and anti-androgenic compound widely administered in prostate cancer which has been evidentially correlated with a severe hepatotoxic potency. Three male p...Cyproterone acetate (CPA) is a steroidal synthetic progestagen and anti-androgenic compound widely administered in prostate cancer which has been evidentially correlated with a severe hepatotoxic potency. Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration. Patients were treated with CPA at the doses of 200-300 mg/d for malignant prostate disease for 3-12 mo prior to the acute manifestation of the hepatic disease. Clinical features compatible with mixed hepatocellular and cholestatic liver disease including jaundice, white stools and dark urine, manifested in all three cases whereas encephalopathy and ascites were present in two of the patients. Other primary causes of hepatotoxicity (alcohol consumption and viral hepatitis) were also verified in two cases, and in those patients biopsy findings revealed the presence of cirrhotic lesions in liver parenchyma. Discontinuation of the therapeutic agent led to the amelioration of the clinical profile in all the patients whereas a patient died 40 d after hospital admission due to sepsis, despite acute liver disease improvement. The current article highlights the hepatotoxic potency of a widely administered therapeutic agent and illustrates the importance of clinical surveillance especially in patients with previous hepatic diseases. Three relevant cases are reported and a review of the published literature is made.展开更多
This report describes a new three‐component strategy for the regioselective synthesis of a series of tri‐substituted pyridazines via a 1,4‐diazabicyclo[2.2.2]octane （DABCO）‐catalyzed condensation of propiophenon...This report describes a new three‐component strategy for the regioselective synthesis of a series of tri‐substituted pyridazines via a 1,4‐diazabicyclo[2.2.2]octane （DABCO）‐catalyzed condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water. This method provides a green and convenient one‐pot route toward a diverse set of 3,6‐diaryl‐4‐methylpyridazines bearing various aryl substituents. This procedure is highly regioselective, operationally simple, uses water as a safe, environmentally friendly solvent, and DABCO as a green base‐organocatalyst, and affords good to excellent yields of products.展开更多
A simple and efficient process involving the Rh(II)-catalyzed[1+1+3]annulation of diazooxindoles and vinyl azides has been developed for the synthesis of spiropyrrolidine oxindoles with potential biological activity a...A simple and efficient process involving the Rh(II)-catalyzed[1+1+3]annulation of diazooxindoles and vinyl azides has been developed for the synthesis of spiropyrrolidine oxindoles with potential biological activity and significant synthetic applications.This process involves a novel rhodium-catalyzed olefination of diazo compounds,followed by annulation with vinyl azides.This method is compatible with a broad range of substrates and affords moderate to good yields under mild reaction conditions.展开更多
文摘By using the laser-monitoring technique,solid-liquid equilibrium data of glutaric acid in cyclohexanol,cyclohexanone,their five mixed solvents and acetic acid were measured within the temperature range from 292.15K to 354.60K by dynamic method.Empirical formula and λh equation were used to correlate the solubilities of glutaric acid in eight solvents.The maximal average relative deviations were 1.15% and 2.20% by using the em-pirical formula and λh equation to correlate the solubility data.The results showed that the empirical formula and λh model could correlate the solubility data of glutaric acid in eight solvents.In addition,the solubility data of glutaric acid in five mixtures(cyclohexanone+cyclohexanol)could be predicted with the NRTL equation utilizing the pa-rameters of the binary systems.The total average relative deviation was 3.60%.The results indicate that the NRTL equation could well predict the solubilities of glutaric acid in the mixed solvents of cyclohexanone and cyclohexanol.
文摘Cyproterone acetate (CPA) is a steroidal synthetic progestagen and anti-androgenic compound widely administered in prostate cancer which has been evidentially correlated with a severe hepatotoxic potency. Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration. Patients were treated with CPA at the doses of 200-300 mg/d for malignant prostate disease for 3-12 mo prior to the acute manifestation of the hepatic disease. Clinical features compatible with mixed hepatocellular and cholestatic liver disease including jaundice, white stools and dark urine, manifested in all three cases whereas encephalopathy and ascites were present in two of the patients. Other primary causes of hepatotoxicity (alcohol consumption and viral hepatitis) were also verified in two cases, and in those patients biopsy findings revealed the presence of cirrhotic lesions in liver parenchyma. Discontinuation of the therapeutic agent led to the amelioration of the clinical profile in all the patients whereas a patient died 40 d after hospital admission due to sepsis, despite acute liver disease improvement. The current article highlights the hepatotoxic potency of a widely administered therapeutic agent and illustrates the importance of clinical surveillance especially in patients with previous hepatic diseases. Three relevant cases are reported and a review of the published literature is made.
基金supported by the Research Council of Payame Noor University
文摘This report describes a new three‐component strategy for the regioselective synthesis of a series of tri‐substituted pyridazines via a 1,4‐diazabicyclo[2.2.2]octane （DABCO）‐catalyzed condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water. This method provides a green and convenient one‐pot route toward a diverse set of 3,6‐diaryl‐4‐methylpyridazines bearing various aryl substituents. This procedure is highly regioselective, operationally simple, uses water as a safe, environmentally friendly solvent, and DABCO as a green base‐organocatalyst, and affords good to excellent yields of products.
基金supported by the National Natural Science Foundation of China(21572225)~~
文摘A simple and efficient process involving the Rh(II)-catalyzed[1+1+3]annulation of diazooxindoles and vinyl azides has been developed for the synthesis of spiropyrrolidine oxindoles with potential biological activity and significant synthetic applications.This process involves a novel rhodium-catalyzed olefination of diazo compounds,followed by annulation with vinyl azides.This method is compatible with a broad range of substrates and affords moderate to good yields under mild reaction conditions.
