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订书抗菌肽的研究进展
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作者 莫沁梓 郑珩 《国外医药(抗生素分册)》 CAS 2024年第4期217-225,共9页
当前抗菌药物面临日趋严重的抗生素耐药性问题,亟需新结构或新作用机制的抗菌药。抗菌肽因其具有广谱抗菌活性和独特的杀菌机制,被认为是对抗多重耐药细菌的潜在治疗药物,有很好的发展前景。但是,抗菌肽存在结构不稳定,易被蛋白酶水解... 当前抗菌药物面临日趋严重的抗生素耐药性问题,亟需新结构或新作用机制的抗菌药。抗菌肽因其具有广谱抗菌活性和独特的杀菌机制,被认为是对抗多重耐药细菌的潜在治疗药物,有很好的发展前景。但是,抗菌肽存在结构不稳定,易被蛋白酶水解等缺点,为抗菌肽的临床转化带来了阻碍。提高多肽结构稳定性可以使用非天然氨基酸修饰、环化等方法,近年来一种被称为订书修饰的特殊环化方法受到广泛关注,包括使用全碳氢链、三唑基或者硫代碳链桥环钉子等。订书结构的引入可以提高抗菌肽结构的稳定性,尤其是α-螺旋结构的稳定性,增强抗菌肽的活性,还可以抵抗蛋白酶水解,但也存在提高溶血毒副作用的可能。本文介绍了订书肽的结构、合成以及研究中的订书抗菌肽,并讨论了影响其活性的主要因素,以期为新型抗耐药菌药物研发提供帮助。 展开更多
关键词 抗菌肽 订书肽 环化修饰 稳定性 结构
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A review on heterogeneous photocatalysis for environmental remediation:From semiconductors to modification strategies 被引量:17
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作者 Huijie Wang Xin Li +5 位作者 Xiaoxue Zhao Chunyan Li Xianghai Song Peng Zhang Pengwei Huo Xin Li 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2022年第2期178-214,共37页
Heterogeneous photocatalysis,an advanced oxidation process,has garnered extensive attention in the field of environmental remediation because it involves the direct utilization of solar energy for the removal of numer... Heterogeneous photocatalysis,an advanced oxidation process,has garnered extensive attention in the field of environmental remediation because it involves the direct utilization of solar energy for the removal of numerous pollutants.However,the application of heterogeneous photocatalysis in environmental remediation has not achieved the expected consequences due to enormous challenges such as low photocatalytic efficiencies and high costs of heterogeneous photocatalysts in large-scale practical applications.Furthermore,pollutants in the natural environment,including water,air,and solid phases,are diverse and complex.Therefore,extensive efforts should be made to better understand and apply heterogeneous photocatalysis for environmental remediation.Herein,the fundamentals of heterogeneous photocatalysis for environmental remediation are introduced.Then,potential semiconductors and their modification strategies for environmental photocatalysis are systematically presented.Finally,conclusions and prospects are briefly summarized,and the direction for the future development of environmental photocatalysis is explored.This review may provide reference directions toward understanding,researching,and designing photocatalytic remediation systems for various environmental pollutants. 展开更多
关键词 POLLUTANT Heterogeneous photocatalysis Environmental remediation SEMICONDUCTOR Modification strategy
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