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同源建模关键步骤的研究动态 被引量:13
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作者 曾炳佳 曹以诚 +1 位作者 杜正平 陈晓曦 《生物学杂志》 CAS CSCD 2008年第2期7-10,共4页
应用同源建模的蛋白质结构预测已经成为一种快速获得蛋白质结构的技术,这种技术也将成为完成结构基因组计划的有力工具。同源建模是指寻找与目标序列同源而且有实验测定结构的蛋白质作为模板,从而构建目标序列的结构模型的方法。限制这... 应用同源建模的蛋白质结构预测已经成为一种快速获得蛋白质结构的技术,这种技术也将成为完成结构基因组计划的有力工具。同源建模是指寻找与目标序列同源而且有实验测定结构的蛋白质作为模板,从而构建目标序列的结构模型的方法。限制这种方法的应用主要是同源建模的关键步骤,即目标与模板之间序列比对和环区建模的准确性。当模型的准确性达到令人信服的程度时,更为精确的计算机辅助药物设计和改造蛋白质,甚至设计全新功能的蛋白质将成为可能。综述了从算法和策略上提高同源建模关键步骤准确性的研究进展。 展开更多
关键词 蛋白质结构预测 同源 目标板比对 环区建模
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The Influences of CPTED on Fear of Crime and Sense of Community
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作者 Siti Rasidah Md Sakip Noraini Johari Mohd Najib Mohd Salleh 《Journal of Environmental Science and Engineering(B)》 2012年第9期1094-1103,共10页
Fear of crime varies considerably depending on its attitude towards environmental conditions. Sense of community and CPTED (crime prevention through environmental design) are believed to have an influence on fear of... Fear of crime varies considerably depending on its attitude towards environmental conditions. Sense of community and CPTED (crime prevention through environmental design) are believed to have an influence on fear of crime. This paper investigates the hypotheses of influences of CPTED on FOC (fear of crime) and SOC (sense of community). A total of 171 respondents from the designated residential areas were involved in this study. The structural equation modeling technique was employed and the results indicate that CPTED has a direct influence on fear of crime and sense of community. However, no significant relationship was found between SOC and FOC. 展开更多
关键词 CPTED fear of crime sense of community structural equation modeling.
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Modeling the distribution of Populus euphratica in the Heihe River Basin, an inland river basin in an arid region of China 被引量:16
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作者 Yanlong GUO Xin LI +1 位作者 Zefang ZHAO Haiyan WEI 《Science China Earth Sciences》 SCIE EI CAS CSCD 2018年第11期1669-1684,共16页
Populus euphratica is a dominant tree species in riparian Tugai forests and forms a natural barrier that maintains the stability of local oases in arid inland river basins. Despite being critical information for local... Populus euphratica is a dominant tree species in riparian Tugai forests and forms a natural barrier that maintains the stability of local oases in arid inland river basins. Despite being critical information for local environmental protection and recovery, establishing the specific spatial distribution of P. euphratica has rarely been attempted via precise and reliable species distribution models in such areas. In this research, the potential geographic distribution of P. euphratica in the Heihe River Basin was simulated with MaxEnt software based on species occurrence data and 29 environmental variables. The result showed that in the Heihe River Basin, 820 km^2 of land primarily distributed along the banks of the lower reaches of the river is a suitable habitat for P. euphratica. We built other MaxEnt models based on different environmental variables and another eight models employing different mathematical algorithms based on the same 29 environmental variables to demonstrate the superiority of this method.MaxEnt based on 29 environmental variables performed the best among these models, as it precisely described the essential characteristics of the distribution of P. euphratica forest land. This study verified that MaxEnt can serve as an effective tool for species distribution in extremely arid regions with sufficient and reliable environmental variables. The results suggest that there may be a larger area of P. euphratica forest distribution in the study area and that ecological conservation and management of P.euphratica should prioritize suitable habitat. This research provides valuable insights for the conservation and management of degraded P. euphratica riparian forests. 展开更多
关键词 Populus euphratica MAXENT Species distribution models Model comparison Inland river basin
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