Objective To evaluate the effects of environmental factors and microRNAs (miRNAs) (miR-126, miR-143, and miR-145) on the risk of coronary heart disease (CHD). Methods A frequency-matched case-control study (450...Objective To evaluate the effects of environmental factors and microRNAs (miRNAs) (miR-126, miR-143, and miR-145) on the risk of coronary heart disease (CHD). Methods A frequency-matched case-control study (450 patients, 450 controls) was conducted from April 2014 to December 2016 in Fuzhou City, China. Environmental factors were investigated using a self-administered questionnaire, and the expression levels of miR-126, rniR-143, and miR-145 were determined by quantitative real-time Polymerase Chain Reaction (PCR) in pe- ripheral blood mononuclear cells. Unconditional logistic regression models were used for statistical evaluation. Results Alcohol consumption, high-salt diets, high-intensity work, and lack of physical activity were significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. MiR-126, miR-143, and miR-145 were highly expressed in the CHD group compared with the control group. After adjustment for other environmental factors, unconditional logistic regression results revealed that miR-126, miR-143, and depression were the independent risk factors of CHD, and light diet was the independent protective factor of CHD. Conclusions Our data suggest that a family history of CHD, anxiety, and alcohol consumption was significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. Furthermore, miR-126 and miR-143 in combination with several risk factors, could play a joint role in the development of CHD. Therefore, it is necessary to manage patients with CHD in all directions and multiple level.展开更多
Damage alarming and safety evaluation using long-term monitoring data is an area of significant research activity for long-span bridges. In order to extend the research in this field, the damage alarming technique for...Damage alarming and safety evaluation using long-term monitoring data is an area of significant research activity for long-span bridges. In order to extend the research in this field, the damage alarming technique for bridge expansion joints based on long-term monitoring data was developed. The effects of environmental factors on the expansion joint displacement were analyzed. Multiple linear regression models were obtained to describe the correlation between displacements and the dominant environmental factors. The damage alarming index was defined based on the multiple regression models. At last, the X-bar control chart was utilized to detect the abnormal change of the displacements. Analysis results reveal that temperature and traffic condition are the dominant environmental factors to influence the displacement. When the confidence level of X-bar control chart is set to be 0.003, the false-positive indications of damage can be avoided. The damage sensitivity analysis shows that the proper X-bar control chart can detect 0.1 cm damage-induced change of the expansion joint displacement. It is reasonably believed that the proposed technique is robust against false-positive indication of damage and suitable to alarm the possible future damage of the expansion joints.展开更多
文摘Objective To evaluate the effects of environmental factors and microRNAs (miRNAs) (miR-126, miR-143, and miR-145) on the risk of coronary heart disease (CHD). Methods A frequency-matched case-control study (450 patients, 450 controls) was conducted from April 2014 to December 2016 in Fuzhou City, China. Environmental factors were investigated using a self-administered questionnaire, and the expression levels of miR-126, rniR-143, and miR-145 were determined by quantitative real-time Polymerase Chain Reaction (PCR) in pe- ripheral blood mononuclear cells. Unconditional logistic regression models were used for statistical evaluation. Results Alcohol consumption, high-salt diets, high-intensity work, and lack of physical activity were significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. MiR-126, miR-143, and miR-145 were highly expressed in the CHD group compared with the control group. After adjustment for other environmental factors, unconditional logistic regression results revealed that miR-126, miR-143, and depression were the independent risk factors of CHD, and light diet was the independent protective factor of CHD. Conclusions Our data suggest that a family history of CHD, anxiety, and alcohol consumption was significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. Furthermore, miR-126 and miR-143 in combination with several risk factors, could play a joint role in the development of CHD. Therefore, it is necessary to manage patients with CHD in all directions and multiple level.
基金Project(2009BAG15B03) supported by the National Science and Technology Ministry of ChinaProjects(51178100, 51078080) supported by the National Natural Science Foundation of China+1 种基金Project(BK2011141) supported by the Natural Science Foundation of Jiangsu Province, ChinaProject(12KB02) supported by the Open Fund of the Key Laboratory for Safety Control of Bridge Engineering(Changsha University of Science and Technology), Ministry of Education, China
文摘Damage alarming and safety evaluation using long-term monitoring data is an area of significant research activity for long-span bridges. In order to extend the research in this field, the damage alarming technique for bridge expansion joints based on long-term monitoring data was developed. The effects of environmental factors on the expansion joint displacement were analyzed. Multiple linear regression models were obtained to describe the correlation between displacements and the dominant environmental factors. The damage alarming index was defined based on the multiple regression models. At last, the X-bar control chart was utilized to detect the abnormal change of the displacements. Analysis results reveal that temperature and traffic condition are the dominant environmental factors to influence the displacement. When the confidence level of X-bar control chart is set to be 0.003, the false-positive indications of damage can be avoided. The damage sensitivity analysis shows that the proper X-bar control chart can detect 0.1 cm damage-induced change of the expansion joint displacement. It is reasonably believed that the proposed technique is robust against false-positive indication of damage and suitable to alarm the possible future damage of the expansion joints.