MICRORNAs (miRNAs) are short (20-22 nucleotldes),non-coding RNA molecules involved in the regulation of mRNAs by pairing with their 3'-untranslated region (3'-UTR) and affecting their stability or directing th...MICRORNAs (miRNAs) are short (20-22 nucleotldes),non-coding RNA molecules involved in the regulation of mRNAs by pairing with their 3'-untranslated region (3'-UTR) and affecting their stability or directing their silencing or degradation.1 miRNAs are likely to play roles in most cellular processes,including proliferation,development,differentiation,and apoptosis.2 People have made progress in the research of miRNA field,but the study about microRNA-346 (miR-346) is very little.This study used biological software to analyze the biological characters of miR-346,and further reviewed the function of miR-346 and its roles in human diseases.展开更多
Objective To provide a set of useful analysis tools for the researchers to explore the microRNA data. Methods The R language was used for generating the Graphical Users Interface and implementing most functions. Some ...Objective To provide a set of useful analysis tools for the researchers to explore the microRNA data. Methods The R language was used for generating the Graphical Users Interface and implementing most functions. Some Practical Extraction and Report Language (Perl) scripts were used for parsing source files. Results We developed a graphical R package named miRE, which was designated for the analysis of microRNA functions, genomic organization, etc. This package provided effective and convenient tools for molecular biologists to deal with routine analyses in microRNA-related research. With its help, the users would be able to build a desktop- centered microRNA research environment quite easily and effectively. miRE is freely available at http://www. biosino.org/~kanghu/WorkPresentation/miRE/miRE.html. A detailed user manual and tutorials with example code and image are also available. Conclusion miRE is a tool providing an open-source, user-friendly, integrated interface for microRNA-related analysis. With its help, researchers can perform microRNA-related analysis more efficiently.展开更多
Recent years,one of the most striking findings in the field of biomedical science is the identification of miRNAs,which are small endogenous non-coding transcripts of*22nucleotides.miRNAs are thought to bind to the co...Recent years,one of the most striking findings in the field of biomedical science is the identification of miRNAs,which are small endogenous non-coding transcripts of*22nucleotides.miRNAs are thought to bind to the complementary sites in their 30-untranslated region(30-UTR)of target mRNAs,and in turn modulate the stability and translational potentiality of these mRNA targets.It has been well documented that miRNAs play important roles in various important biological processes including embryo-展开更多
文摘MICRORNAs (miRNAs) are short (20-22 nucleotldes),non-coding RNA molecules involved in the regulation of mRNAs by pairing with their 3'-untranslated region (3'-UTR) and affecting their stability or directing their silencing or degradation.1 miRNAs are likely to play roles in most cellular processes,including proliferation,development,differentiation,and apoptosis.2 People have made progress in the research of miRNA field,but the study about microRNA-346 (miR-346) is very little.This study used biological software to analyze the biological characters of miR-346,and further reviewed the function of miR-346 and its roles in human diseases.
基金Supported by the National Basic Research Programs of China (2006CB504100, 2007CB946900) National Science Foundation of China (90612019, 30721063, 30430200, 90608022)Program for New Century Excellent Talents in University (NCET-07-0505).
文摘Objective To provide a set of useful analysis tools for the researchers to explore the microRNA data. Methods The R language was used for generating the Graphical Users Interface and implementing most functions. Some Practical Extraction and Report Language (Perl) scripts were used for parsing source files. Results We developed a graphical R package named miRE, which was designated for the analysis of microRNA functions, genomic organization, etc. This package provided effective and convenient tools for molecular biologists to deal with routine analyses in microRNA-related research. With its help, the users would be able to build a desktop- centered microRNA research environment quite easily and effectively. miRE is freely available at http://www. biosino.org/~kanghu/WorkPresentation/miRE/miRE.html. A detailed user manual and tutorials with example code and image are also available. Conclusion miRE is a tool providing an open-source, user-friendly, integrated interface for microRNA-related analysis. With its help, researchers can perform microRNA-related analysis more efficiently.
文摘Recent years,one of the most striking findings in the field of biomedical science is the identification of miRNAs,which are small endogenous non-coding transcripts of*22nucleotides.miRNAs are thought to bind to the complementary sites in their 30-untranslated region(30-UTR)of target mRNAs,and in turn modulate the stability and translational potentiality of these mRNA targets.It has been well documented that miRNAs play important roles in various important biological processes including embryo-
