Aim To design and synthesize a series of 2-（E）-（4-cyclopentyloxy-3-methoxylbenzylidene）cyclopentanone derivatives, and to determine their antitumor activities in vitro. Method The target compounds were synthesized...Aim To design and synthesize a series of 2-（E）-（4-cyclopentyloxy-3-methoxylbenzylidene）cyclopentanone derivatives, and to determine their antitumor activities in vitro. Method The target compounds were synthesized. Their antitumor activities were assayed using human hepatic carcinoma ceil line （Bel-7402） and human oral cavity epidermis squamoceilular carcinoma cell line （KB）. Results Five compounds were obtained. Three of them were not reported in the literature and their chemical structures were confirmed by IR, ^1H NMR, MS and elemental analysis. Preliminary screening results showed that compound 5 possessed better biological activity with IC50 1.62 μmol·L^-1 against Bel-7402 and 8.04 μmol·L^-1 against KB, but much weaker than 5- Fluorouracil. Conclusion Mannich base derivatives of 2-（E）-（4-cyclopentyloxy-3-methoxylbenzylidene）cyclopentanone exhibited some antitumor activities.展开更多
The title complex [(h5-C5H5)(THF)Sm]2[m-h2:h2-N2Ph2]22THF has been synthe- sized by the reaction of divalent (C5H5)2Sm(THF) with azobenzene and its crystal structure was determined by single-crystal X-ray diffraction ...The title complex [(h5-C5H5)(THF)Sm]2[m-h2:h2-N2Ph2]22THF has been synthe- sized by the reaction of divalent (C5H5)2Sm(THF) with azobenzene and its crystal structure was determined by single-crystal X-ray diffraction analysis. It crystallizes in triclinic, space group P with a = 9.1617(16), b = 10.5894(17), c = 11.957(2) ? a = 85.789(6), b = 89.395(7), g = 82.503(6), V = 1147.0(3) ?, Z = 1, C50H62N4O4Sm2, Mr = 1083.74, Dc = 1.569 g/cm3, F(000) = 546 and m(MoKa) = 2.583 mm-1. The structure was solved by direct methods and refined by full-matrix least-squares techniques. The final R and wR are 0.0271 and 0.0637, respectively for 4963 independent reflections. Each samarium atom is involved in two single bonds (one to each N2Ph2 unit) and two donor bonds (one to each N2Ph2 unit).展开更多
The crystal and molecular structure of 4, 5-trans-2-amino-1, 3, 3-tri-cyano-4, 5-di(4-chlorophenyl) cyclopentene. ethanol - monohydrate has been deter-mined by X-ray diffraction method. The crystal (C20H12N4Cl2. C2H6O...The crystal and molecular structure of 4, 5-trans-2-amino-1, 3, 3-tri-cyano-4, 5-di(4-chlorophenyl) cyclopentene. ethanol - monohydrate has been deter-mined by X-ray diffraction method. The crystal (C20H12N4Cl2. C2H6O. H2O, Mr=443. 33) is triclinic with space group P1, a= 11. 033(4), b= 12. 199(3), c= 10. 732(3) A, a=114. 46(2), β=118. 33(3) γ=81. 56(3), V=1155- 1(7) A3, Z=2, Dc= 1. 275g/cm3, μ(MoKa) = 3. 05cm-1, F(000) = 460, R= 0. 070, Rw = 0. 089 for1965 observed reflections (I>3(I)). The phenyl groups are in equatorial positionsand form dihedral angles of 67. 89 and 63. 77° with the central 5-ring. X-ray analysisreveals that in the five membered ring the C (1) -C (2) bond is longer than normal double C=C bond while the C(2) -N (2) bond is shorter than normal C(sp)2-N bond.展开更多
基金Natural Science Foundation of GuangdongProvince(Grant No.994615).
文摘Aim To design and synthesize a series of 2-（E）-（4-cyclopentyloxy-3-methoxylbenzylidene）cyclopentanone derivatives, and to determine their antitumor activities in vitro. Method The target compounds were synthesized. Their antitumor activities were assayed using human hepatic carcinoma ceil line （Bel-7402） and human oral cavity epidermis squamoceilular carcinoma cell line （KB）. Results Five compounds were obtained. Three of them were not reported in the literature and their chemical structures were confirmed by IR, ^1H NMR, MS and elemental analysis. Preliminary screening results showed that compound 5 possessed better biological activity with IC50 1.62 μmol·L^-1 against Bel-7402 and 8.04 μmol·L^-1 against KB, but much weaker than 5- Fluorouracil. Conclusion Mannich base derivatives of 2-（E）-（4-cyclopentyloxy-3-methoxylbenzylidene）cyclopentanone exhibited some antitumor activities.
基金Qinglan Foundation of Jiangsu Province and the Foundation of Educational Ministry of Jiangsu Province
文摘The title complex [(h5-C5H5)(THF)Sm]2[m-h2:h2-N2Ph2]22THF has been synthe- sized by the reaction of divalent (C5H5)2Sm(THF) with azobenzene and its crystal structure was determined by single-crystal X-ray diffraction analysis. It crystallizes in triclinic, space group P with a = 9.1617(16), b = 10.5894(17), c = 11.957(2) ? a = 85.789(6), b = 89.395(7), g = 82.503(6), V = 1147.0(3) ?, Z = 1, C50H62N4O4Sm2, Mr = 1083.74, Dc = 1.569 g/cm3, F(000) = 546 and m(MoKa) = 2.583 mm-1. The structure was solved by direct methods and refined by full-matrix least-squares techniques. The final R and wR are 0.0271 and 0.0637, respectively for 4963 independent reflections. Each samarium atom is involved in two single bonds (one to each N2Ph2 unit) and two donor bonds (one to each N2Ph2 unit).
文摘The crystal and molecular structure of 4, 5-trans-2-amino-1, 3, 3-tri-cyano-4, 5-di(4-chlorophenyl) cyclopentene. ethanol - monohydrate has been deter-mined by X-ray diffraction method. The crystal (C20H12N4Cl2. C2H6O. H2O, Mr=443. 33) is triclinic with space group P1, a= 11. 033(4), b= 12. 199(3), c= 10. 732(3) A, a=114. 46(2), β=118. 33(3) γ=81. 56(3), V=1155- 1(7) A3, Z=2, Dc= 1. 275g/cm3, μ(MoKa) = 3. 05cm-1, F(000) = 460, R= 0. 070, Rw = 0. 089 for1965 observed reflections (I>3(I)). The phenyl groups are in equatorial positionsand form dihedral angles of 67. 89 and 63. 77° with the central 5-ring. X-ray analysisreveals that in the five membered ring the C (1) -C (2) bond is longer than normal double C=C bond while the C(2) -N (2) bond is shorter than normal C(sp)2-N bond.
