A novel hydroxamic acid,N-hydroxy-9,10-epoxy group-octadecanamide(N-OH-9,10-O-ODA),was synthesised by modifying the structure of oleic acid.The carboxyl group of oleic acid was converted into an N-hydroxy amide group,...A novel hydroxamic acid,N-hydroxy-9,10-epoxy group-octadecanamide(N-OH-9,10-O-ODA),was synthesised by modifying the structure of oleic acid.The carboxyl group of oleic acid was converted into an N-hydroxy amide group,and an epoxy group was introduced into its structure.N-OH-9,10-O-ODA was used as a novel collector in the flotation separation of spodumene from one of its associated gangue minerals,specifically albite.N-OH-9,10-O-ODA exhibits remarkable selectivity,with a stronger affinity for collecting spodumene particles compared to albite particles.Zeta potential measurements and X-ray photoelectron spectroscopic analysis reveal that the adsorption quantity of N-OH-9,10-O-ODA on spodumene surface is comparable to that on albite surface.First-principles calculations demonstrate the diverse adsorption configurations of N-OH-9,10-O-ODA on surfaces of spodumene and albite,leading to its distinct collecting abilities for spodumene and albite particles.展开更多
（S）-（＋）-2,2-dimethylcyclopropane carbox amide is a key intermediate of Cilastatin, an inhibitor of dehydropeptidase-I. Its corresponding solid-liquid equilibrium data will provide essential support for industrial...（S）-（＋）-2,2-dimethylcyclopropane carbox amide is a key intermediate of Cilastatin, an inhibitor of dehydropeptidase-I. Its corresponding solid-liquid equilibrium data will provide essential support for industrial design and further theoretical studies. The solubilities of （S）-（＋）-2,2-dimethylcyclopropane carbox amide in toluene, dichloromethane, trichloromethane, ethyl acetate, ethanol and pure water at different temperature were measured using the synthetic method by a laser monitoring observation technique. The solubility data were correlated with the modified Apelblat equation.The calculated values were good in agreement with the experimental values.展开更多
In this paper, poly(amide-6-β-ethylene oxide) (PEBA1657) copolymer was used to prepare multilayer polyetherimide (PEI)/polydimethylsiloxane (PDMS)/PEBA1657/PDMS composite membranes by dip-coating method. Permeation b...In this paper, poly(amide-6-β-ethylene oxide) (PEBA1657) copolymer was used to prepare multilayer polyetherimide (PEI)/polydimethylsiloxane (PDMS)/PEBA1657/PDMS composite membranes by dip-coating method. Permeation behaviors of ethylene, ethane, propylene, propane, n-butane, methane and nitrogen through the multilayer composite membranes were investigated over a range of operating temperature and pressure. The permeances of light hydrocarbons through PEI/PDMS/PEBA1657/PDMS composite membranes increase with their increasing condensability, and the olefins are more permeable than their corresponding paraffins. For light hydrocarbons, the gas permeances increase significantly as temperature increasing. When the transmembrane pressure difference increases, the gas permeance increases moderately due to plasticization effect, while their apparent activation energies for permeation decrease.展开更多
The title compound, 1,12,15 triaza 3,4:9,10 dibenzo 5,8 dioxacyclopentadecane N acetic lactam (C 22 H 29 N 3O 3Br 2, M r =543.29) has been synthesized and characterized by analytical data, IR and 1HNMR spectra. The co...The title compound, 1,12,15 triaza 3,4:9,10 dibenzo 5,8 dioxacyclopentadecane N acetic lactam (C 22 H 29 N 3O 3Br 2, M r =543.29) has been synthesized and characterized by analytical data, IR and 1HNMR spectra. The compound crystallizes in the trigonal system, space group R 3 with a = 35.194(1), c = 10.397(1) , γ=120°, V=11152.6(1) 3, Z=18, D c =1.456 gcm -3 , F(000)=4968, μ =3.3 mm -1 . Mo Kα radiation ( λ = 0.71073), R = 0.0145 for 3094 observed reflections 〔 I>2σ(I )〕 of 3392 independent reflections. The result shows that monofunction reaction for polyaza macrocycle were protonized. 1H NMR spectra of the ligand showed two sets of multiplets due to the two phenyl rings of the ligand in different environments.展开更多
A full account of the novel and flexible approach to hydroxylated 8-azabicyclo[3,2,1]octan-3-ones and 9-azabicyclo[3,3,1] nonan-3-ones is presented. Using keto-lactams as the starting materials, this two-step method c...A full account of the novel and flexible approach to hydroxylated 8-azabicyclo[3,2,1]octan-3-ones and 9-azabicyclo[3,3,1] nonan-3-ones is presented. Using keto-lactams as the starting materials, this two-step method consists of silyl enol ether for mation with TBDMSOTf, lactam activation with Tf20/DTBMP, and halide-promoted cyclization. Radical dechlorination of the resulting 1-halotropan-3-ones led to the corresponding hydroxylated tropan-3-ones, which can be hydrogenated to yield 3ct,613-dihydroxytropanes. Starting from optically active keto-lactams, the method has been applied to the enantioselective syntheses of （＋）-（1S,3S,5R,6S）-pervilleine C （6）, （＋）-（1S,3R,5S,6R）-valeroidine （3）, （＋）-（1S,3S,5R,6S）-dibenzoyloxytropane （8） and （＋）-（1S,3S,5R,6S）-merredissine （9）.展开更多
基金financial support from the National Natural Science Foundation of China(Nos.91962223,52104287,U2067201)Hubei Key Laboratory for Efficient Utilization and Agglomeration of Metallurgic Mineral Resources and Open Foundation of State Key Laboratory of Mineral Processing,China(No.BGRIMM-KJSKL-2022-14)。
文摘A novel hydroxamic acid,N-hydroxy-9,10-epoxy group-octadecanamide(N-OH-9,10-O-ODA),was synthesised by modifying the structure of oleic acid.The carboxyl group of oleic acid was converted into an N-hydroxy amide group,and an epoxy group was introduced into its structure.N-OH-9,10-O-ODA was used as a novel collector in the flotation separation of spodumene from one of its associated gangue minerals,specifically albite.N-OH-9,10-O-ODA exhibits remarkable selectivity,with a stronger affinity for collecting spodumene particles compared to albite particles.Zeta potential measurements and X-ray photoelectron spectroscopic analysis reveal that the adsorption quantity of N-OH-9,10-O-ODA on spodumene surface is comparable to that on albite surface.First-principles calculations demonstrate the diverse adsorption configurations of N-OH-9,10-O-ODA on surfaces of spodumene and albite,leading to its distinct collecting abilities for spodumene and albite particles.
文摘（S）-（＋）-2,2-dimethylcyclopropane carbox amide is a key intermediate of Cilastatin, an inhibitor of dehydropeptidase-I. Its corresponding solid-liquid equilibrium data will provide essential support for industrial design and further theoretical studies. The solubilities of （S）-（＋）-2,2-dimethylcyclopropane carbox amide in toluene, dichloromethane, trichloromethane, ethyl acetate, ethanol and pure water at different temperature were measured using the synthetic method by a laser monitoring observation technique. The solubility data were correlated with the modified Apelblat equation.The calculated values were good in agreement with the experimental values.
基金Supported by Key Projects in the National Science & Technology Pillar Program (2011BAC08B00)
文摘In this paper, poly(amide-6-β-ethylene oxide) (PEBA1657) copolymer was used to prepare multilayer polyetherimide (PEI)/polydimethylsiloxane (PDMS)/PEBA1657/PDMS composite membranes by dip-coating method. Permeation behaviors of ethylene, ethane, propylene, propane, n-butane, methane and nitrogen through the multilayer composite membranes were investigated over a range of operating temperature and pressure. The permeances of light hydrocarbons through PEI/PDMS/PEBA1657/PDMS composite membranes increase with their increasing condensability, and the olefins are more permeable than their corresponding paraffins. For light hydrocarbons, the gas permeances increase significantly as temperature increasing. When the transmembrane pressure difference increases, the gas permeance increases moderately due to plasticization effect, while their apparent activation energies for permeation decrease.
文摘The title compound, 1,12,15 triaza 3,4:9,10 dibenzo 5,8 dioxacyclopentadecane N acetic lactam (C 22 H 29 N 3O 3Br 2, M r =543.29) has been synthesized and characterized by analytical data, IR and 1HNMR spectra. The compound crystallizes in the trigonal system, space group R 3 with a = 35.194(1), c = 10.397(1) , γ=120°, V=11152.6(1) 3, Z=18, D c =1.456 gcm -3 , F(000)=4968, μ =3.3 mm -1 . Mo Kα radiation ( λ = 0.71073), R = 0.0145 for 3094 observed reflections 〔 I>2σ(I )〕 of 3392 independent reflections. The result shows that monofunction reaction for polyaza macrocycle were protonized. 1H NMR spectra of the ligand showed two sets of multiplets due to the two phenyl rings of the ligand in different environments.
基金the National Basic Research Program of China(973 Program,2010CB833200)the National Natural Science Foundation of China(21072160,21332007)the Program for Changjiang Scholars and Innovative Research Team at the University of the MOE for financial support
文摘A full account of the novel and flexible approach to hydroxylated 8-azabicyclo[3,2,1]octan-3-ones and 9-azabicyclo[3,3,1] nonan-3-ones is presented. Using keto-lactams as the starting materials, this two-step method consists of silyl enol ether for mation with TBDMSOTf, lactam activation with Tf20/DTBMP, and halide-promoted cyclization. Radical dechlorination of the resulting 1-halotropan-3-ones led to the corresponding hydroxylated tropan-3-ones, which can be hydrogenated to yield 3ct,613-dihydroxytropanes. Starting from optically active keto-lactams, the method has been applied to the enantioselective syntheses of （＋）-（1S,3S,5R,6S）-pervilleine C （6）, （＋）-（1S,3R,5S,6R）-valeroidine （3）, （＋）-（1S,3S,5R,6S）-dibenzoyloxytropane （8） and （＋）-（1S,3S,5R,6S）-merredissine （9）.
