环磷酰胺葡胺注射液治疗慢性心衰

目的探讨环磷酰胺葡胺注射液治疗慢性心衰的疗效。方法将47例慢性心力衰竭（心功能Ⅱ—Ⅳ级）住院患者随机分为两组，对照组20例常规应由利尿剂、ACEI类、B受体阻滞剂及血塞通注射液。治疗组27例，在此基础上加用环磷酰胺葡胺注射液180mg静滴1次／d，10d为一疗程。10d后比较两组疗效。结果治疗组和对照组显效率比较，差异有统计学意义。结论环磷酰胺葡胺注射液治疗慢性心衰有较好疗效。

五加双参片对环磷酰胺损害动物机体造血机能的保护作用

目的 观察五加双参片对环磷酰胺损害动物机体造血机能的保护作用。方法 将实验动物随机分为空白组、对照组、五加双参片(3．75g／kg＼0．8g／kg)2个剂量组，ig，给药的同时ip环磷酰胺注射液，通过检测白细胞和血小板，观察环磷酰胺对小鼠血液细胞的影响。结果 给五加双参片2个剂量组和对照组的白细胞和血小板均高于空白组，经统计学处理有显著性差异(P<0．01)。结论 五加双参片对环磷酰胺损害动物造血机能有保护作用。

清热解毒利湿去疱汤联合西药常规治疗心脾湿热型天疱疮30例

目的:观察清热解毒利湿去疱汤联合醋酸泼尼松片、环磷酰胺注射液治疗心脾湿热型天疱疮的临床疗效。方法:将60例心脾湿热型天疱疮患者随机分为观察组和对照组各30例。对照组给予醋酸泼尼松片、环磷酰胺注射液治疗,治疗组在对照组治疗的基础上给予清热解毒利湿去疱汤,l剂/d。2组均以治疗1个月为1个疗程,疗程间休息2天。结果:观察组痊愈率为73.33%,总有效率为93.33%;对照组痊愈率为50.00%,总有效率为80.00%,2组疗效相比,差异有统计学意义(P<0.05)。起效时间、症状消失时间、治疗时间观察组小于对照组,差异有统计学意义(P<0.05)。结论:清热解毒利湿去疱汤联合醋酸泼尼松片、环磷酰胺注射液治疗心脾湿热型天疱疮临床疗效显著。

Shenfu injection protects against myelosuppression from chemotherapy

Cyclophosphamide is used to treat a variety of tumors. However, the success of the treatment is limited due to severe myelosuppression caused by cyclophosphamide. Administration of cyclophosphamide could significantly decrease white blood cells （WBCs）, platelets, red blood cells （RBCs）, as well as hemoglobin level. The aim of this research is to investigate the protective role of Shenfu injection against cyclophosphamide induced myelosuppression. The results showed that Shenfu injection can markedly enhance the level of WBCs, platelets, RBCs, and hemoglobin of myelosuppressed rat. The level of WBCs, platelets, RBCs, and hemoglobin were increased by 70%-100%, 80%-90%, 10%-20% and 10%-20%, respectively. Furthermore, the protective role of Shenfu injection against myelosuppression was confirmed by the microscopic observation of bone marrow sections. In conclusion, Shenfu injection has a potential protective effect against cyclophosphamide-induced myelotoxicity.