Purpose To investigate the structur e-function relationship between optical coherence tomograp hy(OCT)macular retinal and peripapillary nerve fib er layer(NFL)thick-ness and automated visual field(VF)findings.Design C...Purpose To investigate the structur e-function relationship between optical coherence tomograp hy(OCT)macular retinal and peripapillary nerve fib er layer(NFL)thick-ness and automated visual field(VF)findings.Design Cross-sectional observational stu dy.Methods Retrospective institutional study where 150conse cutive eyes(101sub-jects)from a glaucoma service were included.All the participants had full ophthalmic ev aluation,VF testing and prototype OCT scanning at the sam e visit.Orthogonal OCT macular analysis was obtained to maximize the sam-pling of the area of interest.Pearso n age-adjusted corre-lation was determined between macul ar retinal thickness and peripapillary NFL thickness.Ar ea under the receiver operator characteristics(AROC)curves for the association between macular retinal thickness a nd peripapillary NFL thickness and VF findings were calcu lated in a subgroup of eyes without VF defect and eyes wit h VF defect con-fined to one hemifield.Results The c orrelation between macular retinal and peripapillary N FL measurements ranged between r=0.27to 0.54for quadrants,0.44to0.55for hemiretina,and 0.52for the overall mean.Areas under the receiver operator characteristics for macular thickness were higher in areas corre sponding to the VF defect location than the noncorresp onding locations.Areas under the receiver operator characteristics for peripapillaryNFL thickness were higher than for th e macular retinal thickness.Including both macular r etinal thickness and peripapillary NFL thickness measur ements in the logistic regression model yielded AROCs (range:0.69-0.77)similar to those found for the peripapillary NFL alone.Conclusion Macular retinal thickness,as measured by OCT,was capable of detecting glaucomatous damage and corresponded with peripapillary NFL thickness;however,peripapillary NFL thickness had hig her sensitivity and specificity for the detection of VF a bnormalities.展开更多
Purpose: To analyze retinal nerve fiber layer (RNFL) thickness in eyes with or without visual field (VF) defects after indocyanine green-assisted vitrectomy for idiopathic macular holes using optical coherence tomogra...Purpose: To analyze retinal nerve fiber layer (RNFL) thickness in eyes with or without visual field (VF) defects after indocyanine green-assisted vitrectomy for idiopathic macular holes using optical coherence tomography (OCT) and to investigate the relationship between postoperative VF defects and RNFL damage. Design: Retrospective interventional case series. Participants: Thirty-four eyes of 32 patients with idiopathic macular holes that underwent vitrectomy between January 2001 and March 2003 were included in this study. Eyes were divided into 3 groups according to the occurrence of postoperative VF defects and the use of indocyanine green for internal limiting membrane peeling during surgery: 11 eyes with VF defects after indocyanine green-assisted vitrectomy (group 1),9 eyes without VF defects despite the use of indocyanine green (group 2),and 14 eyes without VF defects that underwent vitrectomy without indocyanine green (group 3). Methods: Retinal nerve fiber layer thickness in each of 4 quadrants (superior,inferior,nasal,temporal)was measured with OCT. Main OutcomeMeasure: Retinal nerve fiber layer thickness around the optic disc. Results: The mean RNFL thickness in 3 of 4 quadrants (superior,nasal,inferior) in group 1 was significantly less than that in the corresponding quadrant in groups 2 and 3 (P < 0.01). In the temporal quadrant,there was a significant difference between groups 1 and 3 (P=0.02),but not between groups 1 and 2. The RNFL thickness in group 1 was significantly less in 3 quadrants in operated eyes than in fellow eyes (P< 0.05). Conclusions: The RNFL thickness was reduced in eyes with VF defects after indocyanine green-assisted vitrectomy for macular holes,suggesting that the postoperativeVF defectsmay have been caused by RNFL damage relating to the use of indocyanine green.展开更多
Frequency doubling perimetry (FDP) may idendtify glaucoma at a relatively early stage even before conventional perimetry does. Scanning laser polarimetry (GDx) has shown to differentiate nerve fiber layer thickness (N...Frequency doubling perimetry (FDP) may idendtify glaucoma at a relatively early stage even before conventional perimetry does. Scanning laser polarimetry (GDx) has shown to differentiate nerve fiber layer thickness (NFLT) between glaucomatous展开更多
Interpretation of quantitative results of nerve fiber layer (NFL) thickness based on scanning laser polarimetry (GDx-NFA) can be quite challenging especially in glaucoma suspects. Purpose: Authors studied NFL paramete...Interpretation of quantitative results of nerve fiber layer (NFL) thickness based on scanning laser polarimetry (GDx-NFA) can be quite challenging especially in glaucoma suspects. Purpose: Authors studied NFL parameters obtained from GDx-NFA in glaucoma suspects and compared them with those of patients with glaucoma Methods: Eighty six glaucoma suspects based展开更多
文摘Purpose To investigate the structur e-function relationship between optical coherence tomograp hy(OCT)macular retinal and peripapillary nerve fib er layer(NFL)thick-ness and automated visual field(VF)findings.Design Cross-sectional observational stu dy.Methods Retrospective institutional study where 150conse cutive eyes(101sub-jects)from a glaucoma service were included.All the participants had full ophthalmic ev aluation,VF testing and prototype OCT scanning at the sam e visit.Orthogonal OCT macular analysis was obtained to maximize the sam-pling of the area of interest.Pearso n age-adjusted corre-lation was determined between macul ar retinal thickness and peripapillary NFL thickness.Ar ea under the receiver operator characteristics(AROC)curves for the association between macular retinal thickness a nd peripapillary NFL thickness and VF findings were calcu lated in a subgroup of eyes without VF defect and eyes wit h VF defect con-fined to one hemifield.Results The c orrelation between macular retinal and peripapillary N FL measurements ranged between r=0.27to 0.54for quadrants,0.44to0.55for hemiretina,and 0.52for the overall mean.Areas under the receiver operator characteristics for macular thickness were higher in areas corre sponding to the VF defect location than the noncorresp onding locations.Areas under the receiver operator characteristics for peripapillaryNFL thickness were higher than for th e macular retinal thickness.Including both macular r etinal thickness and peripapillary NFL thickness measur ements in the logistic regression model yielded AROCs (range:0.69-0.77)similar to those found for the peripapillary NFL alone.Conclusion Macular retinal thickness,as measured by OCT,was capable of detecting glaucomatous damage and corresponded with peripapillary NFL thickness;however,peripapillary NFL thickness had hig her sensitivity and specificity for the detection of VF a bnormalities.
文摘Purpose: To analyze retinal nerve fiber layer (RNFL) thickness in eyes with or without visual field (VF) defects after indocyanine green-assisted vitrectomy for idiopathic macular holes using optical coherence tomography (OCT) and to investigate the relationship between postoperative VF defects and RNFL damage. Design: Retrospective interventional case series. Participants: Thirty-four eyes of 32 patients with idiopathic macular holes that underwent vitrectomy between January 2001 and March 2003 were included in this study. Eyes were divided into 3 groups according to the occurrence of postoperative VF defects and the use of indocyanine green for internal limiting membrane peeling during surgery: 11 eyes with VF defects after indocyanine green-assisted vitrectomy (group 1),9 eyes without VF defects despite the use of indocyanine green (group 2),and 14 eyes without VF defects that underwent vitrectomy without indocyanine green (group 3). Methods: Retinal nerve fiber layer thickness in each of 4 quadrants (superior,inferior,nasal,temporal)was measured with OCT. Main OutcomeMeasure: Retinal nerve fiber layer thickness around the optic disc. Results: The mean RNFL thickness in 3 of 4 quadrants (superior,nasal,inferior) in group 1 was significantly less than that in the corresponding quadrant in groups 2 and 3 (P < 0.01). In the temporal quadrant,there was a significant difference between groups 1 and 3 (P=0.02),but not between groups 1 and 2. The RNFL thickness in group 1 was significantly less in 3 quadrants in operated eyes than in fellow eyes (P< 0.05). Conclusions: The RNFL thickness was reduced in eyes with VF defects after indocyanine green-assisted vitrectomy for macular holes,suggesting that the postoperativeVF defectsmay have been caused by RNFL damage relating to the use of indocyanine green.
文摘Frequency doubling perimetry (FDP) may idendtify glaucoma at a relatively early stage even before conventional perimetry does. Scanning laser polarimetry (GDx) has shown to differentiate nerve fiber layer thickness (NFLT) between glaucomatous
文摘Interpretation of quantitative results of nerve fiber layer (NFL) thickness based on scanning laser polarimetry (GDx-NFA) can be quite challenging especially in glaucoma suspects. Purpose: Authors studied NFL parameters obtained from GDx-NFA in glaucoma suspects and compared them with those of patients with glaucoma Methods: Eighty six glaucoma suspects based
