现代组学技术在中药防治糖脂代谢紊乱机制探索中的应用

糖脂代谢紊乱加速了血管并发症的进展,中药综合调整策略显示出巨大的治疗潜力。然而,中药成分复杂、作用途径多样,严重制约了中药的临床应用及现代化进程。现代组学技术的快速发展为中药治疗糖脂代谢疾病的机制探索创造了有利的条件,使揭示中药治疗糖脂代谢疾病的科学内涵成为可能。近年来研究发现中药可以通过调节肠道菌群、降低炎症因子水平、抑制脂肪生成及脂质累积、减少胰岛β细胞的凋亡、提高胰岛素敏感性、改善胰岛抵抗等多靶点、多途径发挥防治糖脂代谢紊乱的作用。文章通过梳理现代组学技术在中药防治糖脂代谢紊乱机制探索中的应用进展,为精准化、客观化揭示中药防治糖脂代谢紊乱的作用机制提供有益参考,为中药临床应用及开发提供理论支撑。

现代诗一组

眼睛看多了也不多这一眼这一眼。

Organizational Leadership in a Postmodern World： Practical Implications for Contemporary Religious Leaders

We live in an increasingly postmodern society. American Christianity, however, is imbued in a modem---even pre-modern--paradigm. As a result, many contemporary religious leaders find it difficult to communicate with their postmodern constituents, as evidenced by declining attendance rates and religious affiliation. The present study explores this dilemma by offering potential implications for contemporary religious leaders to communicate more effectively with emerging/emergent generation（s）. The author begins this exploration, first, by outlining the philosophical tenants of postmodemism： its epistemological, ontological, and axiological assumptions. Second, the author delineates several key characteristics of postmodern religious communication. Next, the author offers three practical implications for organizational leaders： （1） increased use of personal narrative, （2） removal of hierarchal boundary structures, and （3） increased awareness and appreciation for divergent perspectives. The author concludes this study with directions for future research.

Harnessing pharmacological knowledge for personalized medicine and pharmacotyping: Challenges and lessons learned

The contribution of the genetic make-up to an individual’s capacity has long been recognized in modern pharmacology as a crucial factor leading to therapy ineffciency and toxicity, negatively impacting the economic burden of healthcare and restricting the monitoring of diseases. In practical terms, and in order for drug prescription to be improved toward meeting the personalized medicine concept in drug delivery, the maximum clinical outcome for most, if not all, patients must be achieved, i.e. , pharmacotyping. Such a direction although promising and of high expectation from the society, it is however hardly to be afforded for healthcare worldwide. To overcome any existed hurdles, this means that practical clinical utility of personalized medicine decisions have to be documented and validated in the clinical setting. The latter implies for drug delivery the effcient implementation of previously gained in vivo pharmacology experience with pharmacogenomics knowledge. As an approach to work faster and in a more productive way, the elaboration of advanced physiologically based phar-macokinetics models is discussed. And in better clarifying this topic, the example of tamoxifen is thoroughly presented. Overall, pharmacotyping represents a major challenge in modern therapeutics for which pharmacologists need to work in successfully fulflling this task.

Lordiphosa denticeps Species-Group from Yunnan,China:Description of Four New Species,and Phenomena of Geographical Replacement

Four new species of Lordiphosa denticeps species-group are reported from Yunnan,China,namely Lordiphosa gruicollara sp.nov.,Lordiphosa eminens sp.nov.,Lordiphosa incidens sp.nov.and Lordiphosa piliferous sp.nov.The distribution of the species of denticeps species-group shows distinct geographical replacement.

On Composition Devices in Modernist Architecture： The Case of De Vore House and House II

This paper examines general composition problems in modernist architecture by means of a close analysis of the formal principles and devices at work in two exemplary mid twentieth century projects, De Vore House by Louis Kahn （1901-1974） and House II by Peter Eisenman （1932）. The goal of the paper is to inaugurate a larger research project into the design processes and spatial-formal effect at work in modernist architecture. The methodology is primarily visual, and postulates a range of form relationships for the creation and interpretation of works of architecture. Following an introduction to the research problem, an analysis of the case study projects is undertaken according to three themes： plan disposition, ambiguity in wall and column relations, and volume as impacting on movement. A concluding section summarizes the findings and suggests future lines of research. The paper＇s significance lays in its contributions to discussions around architectural practice at a specific moment in modernist architecture＇s mid twentieth century trajectory, to our understanding of a number of formal strategies and their resulting architectural effects, and to scholarship on the practice and theories of Kahn and Eisenman.

Research on Application of BIM Technology in Project Management

According to the actual requirement of project management on BIM application, the paper presents a new the overall implementation scheme and system architecture based on BIM project management. This paper established the engineering project management process that suitable for the situation of our country, design the organizational structure and verified the rationality through the example simulation based on the study of ideological characteristics of BIM combined with the modem project management theory and method. The research results has a certain theory reference value in our implementation and project management to improve the level of BIM information integration.

From the Pictorial Symbols of the Theatre to the Virtual Symbolisation of the Real

In many representative, literary, cinematic, or artistic products of modern civilization, the problem of world＇s reality and the relationship of the subject with it, are seen from different viewpoints, such as the dimension of the utopian perception of a dreamlike or imaginary composition, subconscious creation, but also more complex versions such as computer mediated complete illusion, artificial intelligence, and control of the brain, intrusion, and influence exerted on the thought of the other using modern technology or any combination of all the above. It is thus understood that the issue at hand can be approached from a variety of viewpoints and aspects, such as the philosophical, psychological, psychoanalytical, technological, neurophysiologieal, sociological, literary and so on Our viewpoint is strictly limited to the theatrical dimension and our analysis will prosress based on data comprising the theatrical phenomenon, that is, the illusion, as opposed to virtual reality of modern technology.

The Research of Value of Female Costume in Ethnic Group Construction Based on the Social Gender

The social gender theory is a historical analysis method which is benificial to explore the system of human organization activities around ＂male＂or ＂female＂ activities. Historically, the process of human socialization is also a process of social gender institutionalization. Therefore, the paper tried to analyze the connotation of ethnic women＇s costume from the social gender perspective to help people realize further the women＇s state in sexism society and value in ethnic group constructing and developing. Firstly, the paper sets forth the characteristic of ＂group＂ of ethnic people female costumes. The next, the paper explored the costume how to set up a system of ethic standard in inner group so as to maintain the social order. Subsequently, the paper points out, with the rapid evolution of society, more and more ethnic people men participate cities construction and outer social activities Consequently, most of minority men wear modem clothing instead of their traditional clothing, only women still insist in wearing the traditional clothing. Finally, according to research above, the authors consider that ethnic people female costumes emerge strong gender content which reflects more constraints rather than equality between men and women. Besides, it is certain that women have irreplaceable value in ethinc group construction and development.

Matter （Pudgalastikaya or Pudgala） in Jain Philosophy

Pudgalastikaya is one of the six constituent dravyas of loka in Jainism and is the only substance that is sense perceptible. The sense attributes ofpudgala are colour, taste, smell, and touch properties which become the basis of its diversity of forms and structures. The smallest constituent of pudgala is paramanu; the other forms are its combinations. The combination ofparmanus forms various states of the matter. The paper describes different types of combinations and modes, rules for combinations and properties of aggregates known as vargana. Some varganas associate with the soul and form various types of bodies of organisms and others exist as forms of matter in loka （universe）. The paramanu defines the smallest units of energy, space, time, and sense quality ofpudgala. Pudgala exists in visible and invisible forms but anything that is visible is definitely pudgala. Pudgala is classified in various ways; one of them is on the basis of touch property and there are pudgalas having two touches, four touches, and eight touches, each class having some specific character that differentiates them in respect of stability and motion. Pudgala is also classified as living, prayoga-parinat, and non-living, visrasa-parinat. The living matter existing as bodies of organisms exhibits some properties that are not found in non-living matter. Modem science has no such distinction which has become a cause of confusion in recognizing the existence of soul. The description of body remains incomplete without considering the presence of soul in the body. In modem terms, aparamanu is a vibrating and moving charge that is bosonic in character. The two-touch and four-touch pudgala do not appear to follow the speed limits prescribed by Special Theory of Relativity. Jain canonical works describe two types of motions sparshad type and asparshad type and these determine the motions of different class ofpudgala and soul. Jain philosophy describes the dynamics and motion ofparmanu in detail. The paper describes the Jain concepts of matter in detail and compares with the modem concepts to highlight the strength of Jain views. Modem science has explored the properties and behavior of matter in great detail but still there are many concepts that Jain philosophy has to offer.

The Construction of＂New Woman＂ in Chen Hengzhe＇s Autobiography

This essay examines the autobiography of Chen Hengzhe （1890-1976） （see Appendix）, a relatively less studied woman writer, historian, and critic in modem China. Through the study in four aspects, namely, the pursuit of modem education, simple appearance, great leaders, and the ambassadors of culture, the author＇s research indicates that Chen＇s construction of＂new woman＂ has been influenced by complex historical and cultural forces such as the Chinese traditional culture, Western culture, and the iconoclastic spirit of ＂the New Culture Movement＂. Meanwhile, Chen＇s gender consciousness is also an important element. Moreover, Chen＇s pioneering standing and her own experiences of studying abroad makes her take the lead in conceiving women＇s leadership and their roles in global culture communications. In the late Qing and the early Republic, traditional values and norms of womanhood were severely challenged. Chen＇s construction of＂new woman＂ is her conscious effort to define a new womanhood and is an integral part of the ongoing exploration of Chinese women for modem womanhood. Through the examination of Chen＇s ＂new woman＂, this paper seeks to enrich our understanding of the complexity of modem Chinese women＇s exploration of modem womanhood.