AIM:To estimate the cost-benefit of endoscopic screening strategies of esophageal cancer(EC)in high-risk areas of China. METHODS:Markov model-based analyses were conducted to compare the net present values(NPVs)and th...AIM:To estimate the cost-benefit of endoscopic screening strategies of esophageal cancer(EC)in high-risk areas of China. METHODS:Markov model-based analyses were conducted to compare the net present values(NPVs)and the benefit-cost ratios(BCRs)of 12 EC endoscopic screening strategies.Strategies varied according to the targeted screening age,screening frequencies,and follow-up intervals.Model parameters were collected from population-based studies in China,published literatures,and surveillance data. RESULTS:Compared with non-screening outcomes,all strategies with hypothetical 100 000 subjects saved life years.Among five dominant strategies determined by the incremental cost-effectiveness analysis,screening once at age 50 years incurred the lowest NPV(international dollar-I$55 million)and BCR(2.52).Screening six times between 40-70 years at a 5-year interval[i.e., six times(40)f-strategy]yielded the highest NPV(I$99 million)and BCR(3.06).Compared with six times(40)fstrategy,screening thrice between 40-70 years at a 10-year interval resulted in relatively lower NPV,but the same BCR. CONCLUSION:EC endoscopic screening is cost-beneficial in high-risk areas of China.Policy-makers should consider the cost-benefit,population acceptance,and local economic status when choosing suitable screening strategies.展开更多
Virtual Reality provides a new approach for geographical research. In this paper, a framework of the Virtual Huanghe （Yellow） River System was first presented from the view of technology, which included five main mo...Virtual Reality provides a new approach for geographical research. In this paper, a framework of the Virtual Huanghe （Yellow） River System was first presented from the view of technology, which included five main modules——data sources, 3D simulation terrain database, 3D simulation model database, 3D simulation implementation and application system. Then the key technoiogies of constructing Virtual Huanghe River System were discussed in detail： 1） OpenGL technology, the 3D graphics developing instrument, was employed in Virtual Huanghe River System to realize the function of dynamic real-time navigation. 2） MO and OpenGL technologies were used to make the mutual response between 3D scene and 2D electronic map available, which made use of the advantages of both 3D scene and 2D electronic map, with the macroscopic view, integrality and conciseness of 2D electronic map combined with the locality, reality and visualization of 3D scene. At the same time the disadvantages of abstract and ambiguity of 2D electronic map and the direction losing of virtual navigation in 3D scene were overcome.展开更多
基金Supported by The National Science and Technology Pillar Program of the 11th National Five-Year Plan of China,No. 2006BAI02A15
文摘AIM:To estimate the cost-benefit of endoscopic screening strategies of esophageal cancer(EC)in high-risk areas of China. METHODS:Markov model-based analyses were conducted to compare the net present values(NPVs)and the benefit-cost ratios(BCRs)of 12 EC endoscopic screening strategies.Strategies varied according to the targeted screening age,screening frequencies,and follow-up intervals.Model parameters were collected from population-based studies in China,published literatures,and surveillance data. RESULTS:Compared with non-screening outcomes,all strategies with hypothetical 100 000 subjects saved life years.Among five dominant strategies determined by the incremental cost-effectiveness analysis,screening once at age 50 years incurred the lowest NPV(international dollar-I$55 million)and BCR(2.52).Screening six times between 40-70 years at a 5-year interval[i.e., six times(40)f-strategy]yielded the highest NPV(I$99 million)and BCR(3.06).Compared with six times(40)fstrategy,screening thrice between 40-70 years at a 10-year interval resulted in relatively lower NPV,but the same BCR. CONCLUSION:EC endoscopic screening is cost-beneficial in high-risk areas of China.Policy-makers should consider the cost-benefit,population acceptance,and local economic status when choosing suitable screening strategies.
基金Under the auspices of the Science Data Sharing Pilot Project of Ministry of Science and Technology of China (No. 2003DEA2C010), Natural Science Fund of Henan University on Virtual City Construction Method (No. 04YBRW026)
文摘Virtual Reality provides a new approach for geographical research. In this paper, a framework of the Virtual Huanghe （Yellow） River System was first presented from the view of technology, which included five main modules——data sources, 3D simulation terrain database, 3D simulation model database, 3D simulation implementation and application system. Then the key technoiogies of constructing Virtual Huanghe River System were discussed in detail： 1） OpenGL technology, the 3D graphics developing instrument, was employed in Virtual Huanghe River System to realize the function of dynamic real-time navigation. 2） MO and OpenGL technologies were used to make the mutual response between 3D scene and 2D electronic map available, which made use of the advantages of both 3D scene and 2D electronic map, with the macroscopic view, integrality and conciseness of 2D electronic map combined with the locality, reality and visualization of 3D scene. At the same time the disadvantages of abstract and ambiguity of 2D electronic map and the direction losing of virtual navigation in 3D scene were overcome.
