AIM：To evaluate the method of noninvasive transient elastography for assessment of histological stage of liver fibrosis in patients with chronic hepatitis C （CHC）.METHODS： Two hundred and thirty-seven patients wit...AIM：To evaluate the method of noninvasive transient elastography for assessment of histological stage of liver fibrosis in patients with chronic hepatitis C （CHC）.METHODS： Two hundred and thirty-seven patients with CHC were included in this study. Liver biopsy was performed under ultrasonography on 217 of the patients, excluding twenty with clear clinical evidence of liver cirrhosis. Fifty subjects without liver disease were enrolled as a control group （stage 0）. Twentyfive patients with sustained virological response （SVR） to interferon （IFN） therapy were also enrolled. These patients underwent liver biopsy before IFN therapy. Examination of liver stiffness （LS） was performed by elastography.RESISTS： Medians （50% levels） of LS were 4.1 （3.5-4.9）, 6.3 （4.8-8.5）, 8.8 （6.8-12.0）, 14.6 （10.5-18.6）, and 22.2 （15.4-28.0）, respectively, in the fibrosis stages 0-4 （P 〈 0.001）. LS was significantly correlated with four serum fibrosis markers. LS values in patients with SVR were 3.8 （3.5-5.6）, 5.2 （4.4-6.8）, 6.8 （6.1-7.6）, and 6.1 （3.6-7.9）, respectively, in the fibrosis stages 1-4. In all stages, LS for patients with SVR was significantly lower than that for patients who did not undergo IFN therapy. LS was significantly correlated with serum concentrations of hyaluronic acid, type Ⅳ collagen, type Ⅳ collagen 7S, and type Ⅲ procollagen N peptide.CONCLUSION： LS correlated well with the histological stage of fibrosis. Changes in liver fibrosis stage may thus be estimated noninvasively using transient elastography.展开更多
The phenomenon of mixed-mode is one of the most important characteristics of switched delay systems. If a networked control system(NCS) with network induced delays and packet dropouts(NIDs & PDs) is recast as a sw...The phenomenon of mixed-mode is one of the most important characteristics of switched delay systems. If a networked control system(NCS) with network induced delays and packet dropouts(NIDs & PDs) is recast as a switched delay system, it is imperative to consider the effects of mixed-modes in the stability analysis for an NCS. In this paper, with the help of the interpolatory quadrature formula and the average dwell time method, stabilization of NCSs using a mixed-mode based switched delay system method is investigated based on a novel constructed Lyapunov-Krasovskii functional. With the Finsler's lemma, new exponential stabilizability conditions with less conservativeness are given for the NCS. Finally, an illustrative example is provided to verify the effectiveness of the developed results.展开更多
Ethnic style is one of the original and special styles in modem fashion. Search for aesthetic inspirations made many designers turn their attention to the rich artistic heritage of national, traditional and even primi...Ethnic style is one of the original and special styles in modem fashion. Search for aesthetic inspirations made many designers turn their attention to the rich artistic heritage of national, traditional and even primitive cultures. Ethnic style known as originated two centuries ago and now it＇ s experiencing second birth.展开更多
文摘AIM：To evaluate the method of noninvasive transient elastography for assessment of histological stage of liver fibrosis in patients with chronic hepatitis C （CHC）.METHODS： Two hundred and thirty-seven patients with CHC were included in this study. Liver biopsy was performed under ultrasonography on 217 of the patients, excluding twenty with clear clinical evidence of liver cirrhosis. Fifty subjects without liver disease were enrolled as a control group （stage 0）. Twentyfive patients with sustained virological response （SVR） to interferon （IFN） therapy were also enrolled. These patients underwent liver biopsy before IFN therapy. Examination of liver stiffness （LS） was performed by elastography.RESISTS： Medians （50% levels） of LS were 4.1 （3.5-4.9）, 6.3 （4.8-8.5）, 8.8 （6.8-12.0）, 14.6 （10.5-18.6）, and 22.2 （15.4-28.0）, respectively, in the fibrosis stages 0-4 （P 〈 0.001）. LS was significantly correlated with four serum fibrosis markers. LS values in patients with SVR were 3.8 （3.5-5.6）, 5.2 （4.4-6.8）, 6.8 （6.1-7.6）, and 6.1 （3.6-7.9）, respectively, in the fibrosis stages 1-4. In all stages, LS for patients with SVR was significantly lower than that for patients who did not undergo IFN therapy. LS was significantly correlated with serum concentrations of hyaluronic acid, type Ⅳ collagen, type Ⅳ collagen 7S, and type Ⅲ procollagen N peptide.CONCLUSION： LS correlated well with the histological stage of fibrosis. Changes in liver fibrosis stage may thus be estimated noninvasively using transient elastography.
基金supported by the National Natural Science Foundation of China(61573230,61473034,51777012)Beijing Nova Programme Interdisciplinary Cooperation Project(Z161100004916041)
文摘The phenomenon of mixed-mode is one of the most important characteristics of switched delay systems. If a networked control system(NCS) with network induced delays and packet dropouts(NIDs & PDs) is recast as a switched delay system, it is imperative to consider the effects of mixed-modes in the stability analysis for an NCS. In this paper, with the help of the interpolatory quadrature formula and the average dwell time method, stabilization of NCSs using a mixed-mode based switched delay system method is investigated based on a novel constructed Lyapunov-Krasovskii functional. With the Finsler's lemma, new exponential stabilizability conditions with less conservativeness are given for the NCS. Finally, an illustrative example is provided to verify the effectiveness of the developed results.
文摘Ethnic style is one of the original and special styles in modem fashion. Search for aesthetic inspirations made many designers turn their attention to the rich artistic heritage of national, traditional and even primitive cultures. Ethnic style known as originated two centuries ago and now it＇ s experiencing second birth.
