Objection:To study the relationship between different doses and biological effect of 32P-glass microspheres(32P-GMS) by percutaneous intra-tumor injection at different times and provide proofs of theory for clinical t...Objection:To study the relationship between different doses and biological effect of 32P-glass microspheres(32P-GMS) by percutaneous intra-tumor injection at different times and provide proofs of theory for clinical therapy.Methods:36 Zealand rabbits and Vx-2 were used to establish the animal model of liver tumor.Six groups were randomly designed.The suspension of different radiative doses of 32P-GMS combined with lipiodol-ultrafluid(0.1 mL) was respectively injected by percutaneous intra-tumor.The tumor tissues were examined by light microscope.MRI examination of liver tumors were performed before and after the injection.Results:C and D groups were observed that the tumor volume was decreased and the rate of restrained tumor was gradually increased after injection of 32P-GMS.The living tumor tissues of E group completely disappeared after the injection for two weeks.MRI examination showed that the tumor signal of E group was equal as T2 as the signal of normal liver parenchyma.The living tumor tissues were not found in F group after the injection for three weeks.Conclusion:111 MBq was the best radiative dose of 32P-GMS for treatment of 1 cm liver cancer by percutaneous intra-tumor injection.MRI examination was very valuable to evaluate the result and follow up after the injection to treat liver cancer.展开更多
目的采用大剂量尿激酶球后注射治疗眼底病引起的玻璃体出血,使出血迅速吸收,便于临床观察眼底,治疗眼底疾病。方法用注射用水1ml 溶尿激酶1万 u 加2%利多卡因0.5ml 进行球后或半球后注射,隔日一次。结果90%的患者有明显疗效,视力不断提...目的采用大剂量尿激酶球后注射治疗眼底病引起的玻璃体出血,使出血迅速吸收,便于临床观察眼底,治疗眼底疾病。方法用注射用水1ml 溶尿激酶1万 u 加2%利多卡因0.5ml 进行球后或半球后注射,隔日一次。结果90%的患者有明显疗效,视力不断提高,10%的患者无效。结论大剂量尿激酶球后注射的方法促使90%玻璃体出血的病人出血迅速吸收,方法简单、方便、安全有效。展开更多
【目的】观察盐酸羟考酮注射液对老年患者全麻苏醒的影响。【方法】在全麻气管插管下行腹腔镜下胃癌根治术的患者60例，年龄65～75岁，ASA分级为Ⅰ～Ⅱ级，患者随机分为三组：羟考酮注射液组（A组）、芬太尼（B组）和对照组（C组），每...【目的】观察盐酸羟考酮注射液对老年患者全麻苏醒的影响。【方法】在全麻气管插管下行腹腔镜下胃癌根治术的患者60例，年龄65～75岁，ASA分级为Ⅰ～Ⅱ级，患者随机分为三组：羟考酮注射液组（A组）、芬太尼（B组）和对照组（C组），每组20例。于手术结束前30 min ，A、B、C三组分别静注羟考酮0．1 mg／kg、芬太尼1μg／kg、生理盐水5 mL。观察比较三组患者拔管时间，定向力恢复时间，镇静评分，不良反应发生情况，拔管时收缩压（SBP）、舒张压（DBP）、心率（HR），拔管后20 min、1 h、2 h的VAS评分。【结果】与A组和C组比较，B组拔管时间延长（ P ＜0．05）；与C组比较，A组和B组镇静评分和定向力恢复时间要优于C组（ P ＜0．05）；与A组比较，B组、C组拔管时SBP、DBP、HR明显增高，且C组高于B组（ P ＜0．05），与A组比较，B组和C组患者在拔管后20 min、1 h、2 h ，VAS评分明显升高，且C组明显高于B组（ P ＜0．05），A组不良反应发生率明显低于B组和C组（ P ＜0．05）。【结论】盐酸羟考酮注射液用于老年腹部肿瘤切除术患者全麻苏醒迅速，血流动力学稳定，镇静满意，镇痛效果好，不良反应少，提高了患者苏醒质量。展开更多
基金a grant from the Tianjin Municipal Commission of Science and Technology(No.003607111)
文摘Objection:To study the relationship between different doses and biological effect of 32P-glass microspheres(32P-GMS) by percutaneous intra-tumor injection at different times and provide proofs of theory for clinical therapy.Methods:36 Zealand rabbits and Vx-2 were used to establish the animal model of liver tumor.Six groups were randomly designed.The suspension of different radiative doses of 32P-GMS combined with lipiodol-ultrafluid(0.1 mL) was respectively injected by percutaneous intra-tumor.The tumor tissues were examined by light microscope.MRI examination of liver tumors were performed before and after the injection.Results:C and D groups were observed that the tumor volume was decreased and the rate of restrained tumor was gradually increased after injection of 32P-GMS.The living tumor tissues of E group completely disappeared after the injection for two weeks.MRI examination showed that the tumor signal of E group was equal as T2 as the signal of normal liver parenchyma.The living tumor tissues were not found in F group after the injection for three weeks.Conclusion:111 MBq was the best radiative dose of 32P-GMS for treatment of 1 cm liver cancer by percutaneous intra-tumor injection.MRI examination was very valuable to evaluate the result and follow up after the injection to treat liver cancer.
文摘目的采用大剂量尿激酶球后注射治疗眼底病引起的玻璃体出血,使出血迅速吸收,便于临床观察眼底,治疗眼底疾病。方法用注射用水1ml 溶尿激酶1万 u 加2%利多卡因0.5ml 进行球后或半球后注射,隔日一次。结果90%的患者有明显疗效,视力不断提高,10%的患者无效。结论大剂量尿激酶球后注射的方法促使90%玻璃体出血的病人出血迅速吸收,方法简单、方便、安全有效。
文摘【目的】观察盐酸羟考酮注射液对老年患者全麻苏醒的影响。【方法】在全麻气管插管下行腹腔镜下胃癌根治术的患者60例，年龄65～75岁，ASA分级为Ⅰ～Ⅱ级，患者随机分为三组：羟考酮注射液组（A组）、芬太尼（B组）和对照组（C组），每组20例。于手术结束前30 min ，A、B、C三组分别静注羟考酮0．1 mg／kg、芬太尼1μg／kg、生理盐水5 mL。观察比较三组患者拔管时间，定向力恢复时间，镇静评分，不良反应发生情况，拔管时收缩压（SBP）、舒张压（DBP）、心率（HR），拔管后20 min、1 h、2 h的VAS评分。【结果】与A组和C组比较，B组拔管时间延长（ P ＜0．05）；与C组比较，A组和B组镇静评分和定向力恢复时间要优于C组（ P ＜0．05）；与A组比较，B组、C组拔管时SBP、DBP、HR明显增高，且C组高于B组（ P ＜0．05），与A组比较，B组和C组患者在拔管后20 min、1 h、2 h ，VAS评分明显升高，且C组明显高于B组（ P ＜0．05），A组不良反应发生率明显低于B组和C组（ P ＜0．05）。【结论】盐酸羟考酮注射液用于老年腹部肿瘤切除术患者全麻苏醒迅速，血流动力学稳定，镇静满意，镇痛效果好，不良反应少，提高了患者苏醒质量。
