We prepared a novel pitch-based activated carbon microsphere（ACM）and studied its in vitro adsorption characteristics for biological molecules.The original spherical asphalt particles were prepared through bitumen em...We prepared a novel pitch-based activated carbon microsphere（ACM）and studied its in vitro adsorption characteristics for biological molecules.The original spherical asphalt particles were prepared through bitumen emulsification.After oxidation and burning,ACMs with a range of parameters were prepared.In vitro adsorption experiments of ACMs for biological molecules were carried out.The prepared ACMs possessed a BET specific surface of 1566 m^2/g with a voidage of 0.653 cm^3/g and a volume of micropores of 0.478 cm^3/g.They showed high adsorption for glucose and creatintine.Compared with the medically used carbon powder,the prepared ACMs exhibited significantly lower adsorption for digestion enzymes.In conclusion,the prepared ACMs,as an oral adsorbent candidate,possessed higher BET specific surface area and larger volume of micropores;they also exhibited favorable selective adsorption features for biological molecules.展开更多
A kind of novel pitch-based activated carbon microsphere（ACM） characterized by its controlled porous structure was developed in this study,the curative effect of this ACM on diabetes mellitus in rats was investigate...A kind of novel pitch-based activated carbon microsphere（ACM） characterized by its controlled porous structure was developed in this study,the curative effect of this ACM on diabetes mellitus in rats was investigated.ACM 0.2-0.3 mm in diameter was prepared by modified method.The optimal ACM was screened by its adsorption ability for glucose.Diabetes mellitus model was established by streptozotocin injection in male Sprague-Dawley rats.Two groups of rats were orally administrated with ACM twice a day for 30 d.Intestinal glucose transport was determined in vitro using everted rat intestinal sacs technique.Compared with the diabetic mellitus group,the ACM treated group showed significant lower blood glucose level and improved glucose tolerance after two-week treatment.If ACM was applied in the mucosal side,glucose permeation clearance in the ACM treated group was significantly higher than that of the control group,especially at high glucose concentration（10 mg/mL） on the serosal side.The selected ACM possessed a BET specific surface of 1566 m^2/g and high volume of micropores（0.478 cm^3/g） with fine spherical morphology,and showed more significant adsorption capacity for glucose.As oral microsphere preparations,ACM presented the curative effect on streptozotocin-induced diabetes mellitus in rats.展开更多
文摘We prepared a novel pitch-based activated carbon microsphere（ACM）and studied its in vitro adsorption characteristics for biological molecules.The original spherical asphalt particles were prepared through bitumen emulsification.After oxidation and burning,ACMs with a range of parameters were prepared.In vitro adsorption experiments of ACMs for biological molecules were carried out.The prepared ACMs possessed a BET specific surface of 1566 m^2/g with a voidage of 0.653 cm^3/g and a volume of micropores of 0.478 cm^3/g.They showed high adsorption for glucose and creatintine.Compared with the medically used carbon powder,the prepared ACMs exhibited significantly lower adsorption for digestion enzymes.In conclusion,the prepared ACMs,as an oral adsorbent candidate,possessed higher BET specific surface area and larger volume of micropores;they also exhibited favorable selective adsorption features for biological molecules.
基金The Ministry of Science and Technology of the People’s Republic of China (Contract No. 2010DFA44300)Shanghai Committee of Science and Technology (Grant No.10DZ2220500 and 11DZ2260600)
文摘A kind of novel pitch-based activated carbon microsphere（ACM） characterized by its controlled porous structure was developed in this study,the curative effect of this ACM on diabetes mellitus in rats was investigated.ACM 0.2-0.3 mm in diameter was prepared by modified method.The optimal ACM was screened by its adsorption ability for glucose.Diabetes mellitus model was established by streptozotocin injection in male Sprague-Dawley rats.Two groups of rats were orally administrated with ACM twice a day for 30 d.Intestinal glucose transport was determined in vitro using everted rat intestinal sacs technique.Compared with the diabetic mellitus group,the ACM treated group showed significant lower blood glucose level and improved glucose tolerance after two-week treatment.If ACM was applied in the mucosal side,glucose permeation clearance in the ACM treated group was significantly higher than that of the control group,especially at high glucose concentration（10 mg/mL） on the serosal side.The selected ACM possessed a BET specific surface of 1566 m^2/g and high volume of micropores（0.478 cm^3/g） with fine spherical morphology,and showed more significant adsorption capacity for glucose.As oral microsphere preparations,ACM presented the curative effect on streptozotocin-induced diabetes mellitus in rats.
