With time going on, the fact that pace of life becomes faster make more and more customers pay more attention to of clothing. In order to survive and develop better and to attract more customers, enterprisesmust have ...With time going on, the fact that pace of life becomes faster make more and more customers pay more attention to of clothing. In order to survive and develop better and to attract more customers, enterprisesmust have the ability to provide the personalized recommendations and the implementation of differentiated business strategy. This text aims to make enterprises understand the customers＇ personalized requirement by using the data processed though questionnaire and rough set theory. And enterprises can provide production and marketing auxiliary decision-making effectively. The feasibility and practicality of rough set theory is verified through the personalized recommendationseases.展开更多
Abacavir is an effective nucleoside analog reverse transcriptase inhibitor used to treat human immunodeficiency virus(HIV) infected patients.Its main side effect is hypersensitivity reaction(HSR).The incidence of the ...Abacavir is an effective nucleoside analog reverse transcriptase inhibitor used to treat human immunodeficiency virus(HIV) infected patients.Its main side effect is hypersensitivity reaction(HSR).The incidence of the HSR is associated with ethnicity among patients exposed to abacavir,and retrospective and prospective studies show a significantly increased risk of abacavir-induced HSR in human leukocyte antigen(HLA)-B*57:01-carrying patients.Immunological studies indicated that abacavir interacts specifically with HLA-B*57:01 and changed the binding specificity between the HLA molecule and the HLA-presented endogenous peptide repertoire,leading to a systemic autoimmune reaction.HLA-B*57:01 screening,combined with patch testing,had clinically predictive value and cost-effective impact in reducing the incidence of abacavir-induced HSR regardless of the HLA-B*57:01 prevalence in the population.Therefore,the US Food and Drug Administration(FDA) and international HIV treatment guidelines recommend a routine HLA-B*57:01 screening prior to abacavir treatment to decrease false positive diagnosis and prevent abacavir-induced HSR.The studies of abacavir-induced HSR and the implementation of the HLA-B*57:01 screening in the clinic represent a successful example of the use of pharmacogenetics for personalized diagnosis and therapy.展开更多
基金This work is supported by the National Natural Science Foundation of China （No. 71301100）, Innovation Program of Shanghai Municipal Education Commission（No. 14YZ140 and No. ZZGJD12036）, Innovation Program of ShanghaiUniversity of Engineering Science （NO. E1-0903-15-01143, Title： 15KY0354Research on personalizedrecommendafionof clothing based on Data Mining） and Doctorate Foundation of Shanghai（No. 11692191400）.
文摘With time going on, the fact that pace of life becomes faster make more and more customers pay more attention to of clothing. In order to survive and develop better and to attract more customers, enterprisesmust have the ability to provide the personalized recommendations and the implementation of differentiated business strategy. This text aims to make enterprises understand the customers＇ personalized requirement by using the data processed though questionnaire and rough set theory. And enterprises can provide production and marketing auxiliary decision-making effectively. The feasibility and practicality of rough set theory is verified through the personalized recommendationseases.
文摘Abacavir is an effective nucleoside analog reverse transcriptase inhibitor used to treat human immunodeficiency virus(HIV) infected patients.Its main side effect is hypersensitivity reaction(HSR).The incidence of the HSR is associated with ethnicity among patients exposed to abacavir,and retrospective and prospective studies show a significantly increased risk of abacavir-induced HSR in human leukocyte antigen(HLA)-B*57:01-carrying patients.Immunological studies indicated that abacavir interacts specifically with HLA-B*57:01 and changed the binding specificity between the HLA molecule and the HLA-presented endogenous peptide repertoire,leading to a systemic autoimmune reaction.HLA-B*57:01 screening,combined with patch testing,had clinically predictive value and cost-effective impact in reducing the incidence of abacavir-induced HSR regardless of the HLA-B*57:01 prevalence in the population.Therefore,the US Food and Drug Administration(FDA) and international HIV treatment guidelines recommend a routine HLA-B*57:01 screening prior to abacavir treatment to decrease false positive diagnosis and prevent abacavir-induced HSR.The studies of abacavir-induced HSR and the implementation of the HLA-B*57:01 screening in the clinic represent a successful example of the use of pharmacogenetics for personalized diagnosis and therapy.
