平乐郭氏正骨理筋法并夹板固定配合壮筋续骨丹在治疗桡骨远端骨折患者中的研究

目的探究平乐郭氏正骨理筋法并夹板固定配合壮筋续骨丹在治疗桡骨远端骨折患者中的疗效。方法将我院2021年7月~2023年7月收治的78例桡骨远端骨折患者纳入研究,通过随机数字表法分为试验组与参考组,每组39例。参考组进行常规治疗,试验组进行平乐郭氏正骨理筋法配合壮筋续骨丹治疗,对比两组治疗效果。结果试验组在采用平乐郭氏正骨理筋法并夹板固定配合壮筋续骨丹治疗,其中医证候积分、骨痂生长状况评分、腕关节活动度均优于参考组,组间差异有统计学意义(P<0.05)。结论在桡骨远端骨折患者治疗过程中,平乐郭氏正骨理筋法并夹板固定配合壮筋续骨丹治疗可以获得较好的效果,可有效改善其相关症状,促进其骨折修复,从而提升腕关节功能。

买氏理血祛风膏对维持性血液透析皮肤瘙痒患者疗效及安全性研究

目的:探讨买氏理血祛风膏对维持性血液透析患者皮肤瘙痒的疗效及安全性。方法:选择80例行维持性血液透析皮肤瘙痒患者,按照随机数字表法分为两组,对照组予氯雷他定联合丁酸氢化可的松乳膏对症治疗,观察组在常规治疗上,加用自拟买氏理血祛风膏治疗,对比两组疗效及安全性情况。结果:观察组疾病疗效总有效率92.5%显著高于对照组总有效率75%(P<0.05)。观察组症候疗效总有效率90%显著高于对照组总有效率72.5%(P<0.05)。两组治疗前后血WBC及肝功能与本组自身比较无统计学差异(P>0.05),两组比较,治疗后也无统计学差异(P>0.05)。治疗后两组BUN、Scr均低于治疗前(P<0.05),Ccr高于治疗前(P<0.05)。两组比较,观察组肾功能各指标均优于对照组(P<0.05)。经治疗观察组患者血甲状旁腺素、血钙、血磷、Scr、BUN水平则显著低于对照组(P<0.05)。结论:买氏理血祛风膏对改善维持性血液透析患者皮肤瘙痒症状疗效显著,安全性较好。

关中李氏骨伤流派关节理筋手法治疗足底筋膜炎的临床研究

目的观察关中李氏骨伤流派关节理筋手法治疗足底筋膜炎的临床疗效并初步探讨其作用机制。方法患者86例采用单纯随机数字抽样法分为治疗组与对照组,治疗组予关中李氏骨伤流派关节理筋手法治疗,对照组采用冲击波治疗。比较两组患者首次治疗前、首次治疗后、末次治疗后的视觉模拟疼痛量表(VAS)评分、动态表面肌电图均方根值(RMS)、有效率。结果两组患者胫骨前肌、腓肠肌内侧头及腓肠肌外侧头的RMS值,在首次治疗后、末次治疗后与首次治疗前比较,差异均有统计学意义(P<0.05)。两组患者在首次治疗后、末次治疗后VAS评分均降低(P<0.05)。两组患者在末次治疗后与首次治疗结束后相比有效率明显升高(P<0.05),治疗组与对照组在首次治疗后、末次治疗后有效率差异无统计学意义(P>0.05)。结论关中李氏骨伤流派关节理筋手法对治疗PF具良好的治疗效果,与冲击波治疗PF具有同等疗效。在治疗后,胫骨前肌、腓肠肌在运动过程中肌肉力量明显增强,肌肉收缩力较治疗前明显改善,肌肉在运动过程中更具有协调性。

平乐郭氏正骨理筋法配合中药在桡骨远端骨折患者术后康复中的应用

目的 探究平乐郭氏正骨理筋法+骨伤中药对桡骨远端骨折患者术后康复的影响。方法 选取我院2020年4月至2021年4月收治的桡骨远端骨折患者(n=86例)为探究对象,根据随机数字表法将入选患者分为配合组及单独组各43例。两组均行手术治疗,术后,单独组行西药+骨伤中药方,配合组在单独组治疗的基础上施加平乐郭氏正骨理筋法治疗。观察两组患者总有效率、并发症发生率。比较两组患者中医证候积分、碱性磷酸酶(ALP)、血清骨钙素(BGP)、骨保护素(OPG)。结果 配合组患者的总有效率明显高于单独组,并发症总发生率明显低于单独组,两组数据有统计学意义(P<0.05)。治疗前,两组患者肿胀、神疲乏力、肢体萎软中医证候积分相较不存在统计学意义(P>0.05);治疗后,两组患者肿胀、神疲乏力、肢体萎软中医证候积分较治疗前呈现显著下降趋势,且配合组患者的上述指标均低于单独组,ALP、OPG、BGP较治疗前呈现增高趋势。两组数据存在统计学意义(P<0.05)。结论 平乐郭氏正骨理筋法+骨伤中药方在桡骨远端骨折患者术后具有理想的康复效果,骨微循环可明显改善,症状可快速缓解,减少并发症,安全有效。

基于三维步态分析技术评价关中李氏骨伤流派关节理筋手法对足底筋膜炎的临床疗效

目的应用三维步态分析技术对关中李氏骨伤流派关节理筋手法治疗足底筋膜炎(PF)的临床疗效研究并初步探讨其作用机理。方法治疗组64例足底筋膜炎患者予关中李氏骨伤流派关节理筋手法治疗,招募本院64例健康职工为健康组。比较足底筋膜炎患者治疗前、后的视觉模拟量表(VAS)评分,比较患者治疗前、治疗后和与健康人在三维步态分析参数的差异。结果治疗组患者在治疗前、治疗后的VAS评分比较有统计学差异(P<0.05)。治疗前与健康组步态参数比较,膝关节矢状面运动角度与踝关节矢状面运动角度存在统计学差异(P<0.05),治疗后与健康比较各参数均无统计学差异(P<0.05)。治疗组治疗前与治疗后比较单步时间、跨步时间、摆动相时间、单步长、跨步长、膝关节矢状面运动角度、踝关节矢状面运动角度均有统计学差异(P<0.05)。结论关中李氏骨伤流派关节理筋手法对治疗PF具良好的治疗效果,患者在VAS评分、步态参数上均有改善。三维步态分析技术可以作为足底筋膜炎疗效的评估手段之一。

买氏理血祛风法联合西药治疗维持性血液透析患者皮肤瘙痒的疗效及对免疫功能、血钙、血磷水平的影响

目的:观察买氏理血祛风法联合西药治疗维持性血液透析患者皮肤瘙痒的疗效及对免疫功能、血钙、血磷水平的影响。方法:将70例维持性血液透析皮肤瘙痒患者按照随机数字表法分为治疗组和对照组,每组35例。对照组给予氯雷他定片,10 mg/次,1次/d,口服;瘙痒处涂抹丁酸氢化可的松乳膏,2~3次/d。治疗组在对照组治疗基础上给予买氏理血祛风汤(药物组成:苦参、防风、土茯苓、当归、川芎、荆芥、白蒺藜、玄参、蝉衣),1 d 1剂,水煎,分早晚两次服用。买氏理血祛风膏每日外用涂抹1次。两组均连续治疗3周判定疗效,其间禁食辛辣刺激性食物和海鲜,戒酒。结果:治疗组痊愈15例,显效11例,有效8例,无效1例,有效率为97.14%(34/35);对照组痊愈9例,显效11例,有效6例,无效9例,有效率为74.29%(26/35)。两组疗效对比,差异有统计学意义(P<0.05)。治疗后,治疗组皮肤瘙痒总评分、血磷、甲状旁腺激素、C反应蛋白、肿瘤坏死因子-α、血肌酐水平、尿素氮水平和生活质量总评分低于对照组,血钙、免疫球蛋白(Ig)A、IgG、IgM、补体C3、补体C4和内生肌酐清除率高于对照组,差异有统计学意义(P<0.01)。结论:买氏理血祛风法联合西药对维持性血液透析患者皮肤瘙痒症状缓解作用明显,可改善钙磷代谢、炎症反应、免疫功能和肾功能。

先秦文献中的“李”字与李氏

本文通过对先秦典籍和出土文献中“李”字及其用法的综合考察，得出关于李氏起源问题的一些结论。李氏出自职官，但并非源自“理氏”。里氏、李氏、理氏是同一姓氏在不同时代用字不同，均源自同一职官。春秋和春秋以前用“里”宇，战国开始用“李”字。而以“理”为氏则是战国以后，职官义普遍写作“理”、姓氏普遍用“李”字。从先秦典籍和出工文献看，先秦不存在“理氏”。

平乐郭氏推拿理筋手法治疗慢性踝关节外侧不稳定的临床研究

目的:探讨平乐郭氏推拿理筋手法在慢性踝关节外侧不稳定(CLAI)治疗中的临床应用效果。方法:将随机选取的82例慢性踝关节外侧不稳定患者分为两组,对照组41例患者行踝关节功能康复锻炼治疗,观察组41例患者在此基础上加行平乐郭氏推拿理筋手法治疗。观察两组患者治疗前、1个疗程结束后、治疗后1个月及末次随访踝关节疼痛视觉模拟量表(VAS)评分和踝关节肿胀值,另记录两组患者治疗前和末次随访美国足踝关节协会(AOFAS)评分、距骨倾斜角和踝关节各韧带厚度,评价临床疗效和安全性。结果:1个疗程结束后、治疗后1个月及末次随访时两组患者VAS评分均依次降低,踝关节肿胀值均依次减小,差异有统计学意义(P<0.05);但观察组与对照组相比以上时间点VAS评分均更低((3.76±0.71)分比(4.14±0.77)分,t=2.279,P=0.025;(2.52±0.58)分比(3.26±0.63)分,t=5.428,P<0.001;(1.84±0.46)分比(2.50±0.52)分,t=5.970,P<0.001),踝关节肿胀值均更小((0.80±0.25)cm比(0.92±0.28)cm,t=2.008,P=0.048;(0.64±0.18)cm比(0.75±0.23)cm,t=2.363,P=0.021;(0.49±0.16)cm比(0.60±0.21)cm,t=2.614,P=0.011)。末次随访时两组患者AOFAS评分均较治疗前升高,距骨倾斜角和关节各韧带厚度较治疗前减小,差异有统计学意义(P<0.05);但观察组与对照组相比末次随访时AOFAS评分更高((86.59±7.27)分比(77.31±14.54)分,t=3.574,P=0.001),距骨倾斜角更小((4.39±0.76)°比(5.68±1.23)°,t=10.809,P<0.001),关节各韧带厚度更小((4.02±0.51)mm比(4.30±0.53)mm,t=2.393,P=0.019;(2.74±0.40)mm比(2.95±0.42)mm,t=2.276,P=0.026;(2.82±0.25)mm比(2.98±0.27)mm,t=2.731,P=0.008)。观察组患者临床疗效优于对照组(Z=8.023,P=0.018),总有效率高于对照组(92.31%比72.50%,χ^(2)=5.313,P=0.021);观察组和对照组并发症发生率分别为5.13%和10.00%,差异无统计学意义(P>0.05)。结论:采用平乐郭氏推拿理筋手法治疗慢性踝关节外侧不稳定患者,能在一定程度上缓解踝关节肿胀和疼痛,促进踝关节韧带、角度以及功能恢复,疗效显著且安全性好。

Influence of Ni_4Ti_3 precipitates on phase transformation of NiTi shape memory alloy

Ni Ti shape memory alloy samples were aged for 2 h at 573, 723 and 873 K, respectively. Two R-phase variants are observed in the Ni Ti samples aged at 573 and 723 K, where the orientation relationship between the two R-phase variants and the B2 matrix is determined. In the Ni Ti samples aged at 573 and 723 K, fine and homogeneous Ni4Ti3 precipitates are coherent with the B2 austenite matrix. The Ni4Ti3 particles precipitate in the grain interior and at the grain boundaries, where the heterogeneous Ni4Ti3 precipitates are coherent, semi-coherent and incoherent with the B2 matrix in the Ni Ti sample aged at 873 K. As for the Ni Ti sample aged at 873 K, one-stage phase transformation from B19＇ martensite to B2 austenite occurs on heating, but two-stage phase transformation of B2-R-B19＇ arises on cooling. The Ni Ti sample aged at 723 K shows two-stage phase transformation of B2-R-B19＇ on cooling as well, but exhibits two-stage phase transformation of B19＇-R-B2 on heating. The Ni Ti sample aged at 573 K exhibits three-stage transformation on cooling due to local stress inhomogeneity and local composition inhomogeneity around the Ni4Ti3 precipitates.

Role of bacteria in the etiopathogenesis of inflammatory bowel disease

Increased numbers of mucosa-associated Escherichia coli are observed in both of the major inflammatory bowel diseases,Crohn's disease(CD)and ulcerative colitis(UC).A potential pathophysiological link between the presence of pathogenic invasive bacteria and genetic host susceptibility of patients with ileal CD is suspected.In CD patients,with increased ileal expression of the CEACAM6 molecule acting as a receptor recognized by type 1 pilus bacterial adhesin,and with the identification of mutations in the NOD2-encoding gene,the presence of pathogenic invasive bacteria could be the link between abnormal ileal bacterial colonization and innate immune responses to invasive bacteria.In a susceptible host,the sequential etiological steps of the disease induced by adherent-invasive E.coli(AIEC)are:(1)abnormal colonization via binding to the CEACAM6 receptor,which is overexpressed in the ileal mucosa of CD patients;(2)ability to adhere to and to invade intestinal epithelial cells,which allows bacteria to cross the mucosal barrier;(3)survival and replication within infected macrophages in the lamina propria;and(4)induction of tumor necrosis factor-α secretion and granuloma formation.

Novel genetic markers in inflammatory bowel disease

Genetic factors play a significant role in determining inflammatory bowel disease(IBD)susceptibility.Epidemiologic data support genetic contribution to the pathogenesis of IBD,which include familial aggregation,twin studies,racial and ethnic differences in disease prevalence.Linkage studies have identified several susceptibility genes contained in different genomic regions named IBD1 to IBD9.Nucleotide oligomerization domain(NOD2)and human leukocyte antigen(HLA)genes are the most extensively studied genetic regions(IBD1 and IBD3 respectively)in IBD.Mutations of the NOD2 gene are associated with Crohn's disease(CD)and several HLA genes are associated with ulcerative colitis(UC)and CD.Toll like receptors(TLRs)have an important role in the innate immune response against infections by mediating recognition of pathogen-associated microbial patterns.Studying single-nucleotide polymorphisms(SNPs)in molecules involved in bacterial recognition seems to be essential to define genetic backgrounds at risk of IBD.Recently,numerous new genes have been identified to be involved in the genetic susceptibility to IBD:NOD1/Caspase-activation recruitment domains 4(CARD4),Chemokine ligand 20(CCL20),IL-11,and IL-18 among others.The characterization of these novel genes potentially will lead to the identification of therapeutic agents and clinical assessment of phenotype and prognosis in patients with IBD.

Investigation of modeling on single grit grinding for martensitic stainless steel

Single grit grinding is the simplified model to abstract the macro scale grinding.Finite element analysis is a strong tool to study the physical fields during a single grit grinding process,compared to experimental research.Based on the dynamic mechanical behavior of 2Cr12Ni4Mo3VNbN steel and the mathematical statistics of abrasive grit,modeling of the single grit grinding process was conducted by using commercial software AdvantEdge.The validation experiment was designed to validate the correctness of the FEA model by contrast with grinding force.The validation result shows that the FEA model can well describe the single grit grinding process.Then the grinding force and multi-physics fields were studied by experimental and simulation results.It was found that both the normal and tangential grinding forces were linearly related to the cutting speed and cutting depth.The maximum temperature is located in the subsurface of the workpiece in front of the grit,while the maximum stress and strain are located under the grit tip.The strain rate can reach as high as about 106 s–1 during the single grit grinding,which is larger than other traditional machining operations.

Immunoproteomics of membrane proteins of Shigella flexneri 2a 2457T

AIM： To screen the immunogenic membrane proteins of Shigella Aexneri 2a 2457T. METHODS： The routine two-dimensional polyacrylamide gel electrophoresis （2-DE） and Western blotting were combined to screen immunogenic proteins of S. Aexneri 2a 2457T. Serum was gained from rabbits immunized with the same bacteria. Immunogenic spots were cut out from the polyacrylamide gel and digested by trypsin in-gel. Matrix-assisted laser desorption/ionization time of flight-mass spectrometry （MALDI-TOF-MS） was performed to determine the molecular weight of peptides. Electrospray ionization （ESI-MS/MS） was performed to determine the sequences of the interesting peptides. RESULTS： A total of 20 spots were successfully identified from Coomassie brilliant blue stained gels representing 13 protein entries, 5 known antigens and 8 novel antigens. A hypothetical protein （YaeT） was detected, which might be a candidate target of vaccine. CONCLUSION： Membrane proteins of S. flexneri 2a 2457T were successfully observed by 2-DE. Several known and novel antigens were identified by mass spectrum.

The role of synphilin-1 in the pathogenesis of Parkinson’s disease

Parkinson’s disease (PD) is one of the commonest neurodegenerative disorders characterized by the loss of dopaminergic (DAergic) neurons in the substantia nigra and the appearance of Lewy bodies (LBs), whose cytoplasmic inclusions are highly enriched with ubiquitin, synphilin-1, α-synuclein and parkin. Synphilin-1 is an α-synuclein-binding protein and a major component of LBs. It is widely accepted that synphilin-1 is involved in the pathogenic process of PD. This review will provide an overall view of the role of synphilin-1 in the pathogenesis of Parkinson’s disease and the latest findings in this field.

Intergranular Corrosion of AISI 304 Heat Treated at 800℃ Varying Range Times

Austenitic stainless steels, when exposed to welding conditions or aging for length of service, it＇s observed the formation of numerous deleterious phases, such as several kinds of carbides type MC, M6C, M7C3, M23C6, and intermetallic secondary phases （sigma, chi, laves）, which cause the process of intergranular corrosion. The aim of this work was verifying the formation of the types of carbides and/or intermetallic phases existing in the stainless AISI 304 at 800 ℃, varying the timing of heat treatment between 30, 360 and 1,440 min. The optical microscopy analysis revealed the predominant formation of the carbide type M23C6. The results of DL-EPR （double loop electrochemical potentiokinetic reactivation） tests showed a gradual increase in the precipitation of this carbide with the increase of treatment time. The potentiodynamic polarization showed that the precipitation of this carbide reduce the formation of the Cr2O3 passive layer, suggesting that the precipitate carbide to be predominantly of the Cr23C6 type.

Low circulating levels of gastrin-17 in patients with Barrett's esophagus

AIM: To examine whether the fasting levels of serum gastrin-17 (G-17) are lower in Barrett's esophagus (BE)patients than in non-Barrett controls.METHODS: Nineteen patients with BE (presenting with a tubular segment ≥2 cm long in lower esophagus and intestinal metaplasia of incomplete type ('specialized columnar epithelium') in endoscopic biopsies from the tubular segment below the squamocolumnar junction were collected prospectively from outpatients referred to diagnostic gastroscopy. The controls comprised 199 prospectively collected dyspeptic outpatients without BE or any endoscopically visible lesions in the upper GI tract.Fasting levels of serum G-17 (G-17fast) were assayed with an EIA test using a Mab highly specific to amidated G-17. None of the patients and controls received therapy with PPIs or other antisecretory agents.RESULTS: The mean and median levels of G-17fast in serum were significantly lower (P = 0.001) in BE patients than in controls. The positive likelihood ratios (LR+) of low G-17fast to predict BE in the whole study population at G-17fast levels ＜0.5, ＜1, or ＜1.5 pmol/L were 3.5, 3.0,and 2.8, respectively. Among patients and controls with healthy stomach mucosa, the LR+ were 5.6, 3.8, and 2.6,respectively. In the whole study population, serum G-17 was below 2 pmol/L in 15 of 19 BE patients (79%). The corresponding prevalence was 66 of 199 (33%) in controls (P＜0.001). The G-17fast was 5 pmol/L or more in only one of the 19 BE patients (5%). In controls, 76 of the 199 patients (38%) had such high serum G-17fast levels (P＜0.01).CONCLUSION: Serum levels of G-17fast tend to be lower in native patients with BE than in healthy controls.

The role of DJ-1 in the pathogenesis of Parkinson’s disease

Parkinson’s disease (PD) is a slowly progressive neurodegenerative disorder characterized clinically by bradykinesia, rigidity, tremor, gait dysfunction, and postural instability. Several genes have been identified for monogenic disorders that variably resemble Parkinson’s disease. Here, we focus on PARK7, a gene relates to an autosomal recessive form of early-onset Parkinsonism and encodes a protein named DJ-1. Though the exact role of DJ-1 needs to be elucidated, it is generally thought to be functioned as a molecular chaperone and an oxidative sensor (or antioxidative factor). We will review the protective role of DJ-1 to prevent dopaminergic neurons in the substantia nigra pars compacta (SNpc) from degeneration and how its dysfunction would lead to neurodegeneration.

张海岑研究员论治郁证三变

著名中医张海岑研究员根据长期临床实践从理论上深入发挥了前人郁病三变(肝气、肝火、肝风)之说,并提出了各证的治则及自拟方。对郁证证治很有参考意义。

RELATIONSHIP OF HOMOCYSTEINE AND GENE POLYMORPHISMS OF ITS RELATED METABOLIC ENZYMES WITH ALZHEIMER'S DISEASE

Objective To investigate the relationship of plasma homocysteine (Hcy) levels and the gene polymorphisms of N5, N10-methylenetetrahydrofolate reductase (MTHFR), cystathionine β-synthase (CBS) with Alzheimer’s disease (AD). Methods Plasma Hcy levels were measured by means of high voltage capillary electrophoresis with ultra-violet detection, the polymorphisms of C677T in exon 4 of MTHFR gene and 844ins68 in exon 8 of CBS gene were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 105 AD patients and 102 non-AD controls. All controls were excluded from cardiocerebrovascular disorders and other diseases. Results The plasma Hcy level in AD patients (16.04 ± 3.84 μmol/L) was significantly higher than that in the controls(11.94 ± 3.87 μmol/L, P < 0.001). There were no significant differences of the genotype and allele frequencies of MTHFR C677T mutation and CBS 844ins68 mutation between the patients and controls. However, the T allele of MTHFR gene was found to relate with the plasma Hcy level increase in all subjects. Conclusion The elevated plasma Hcy level in AD patients is probably involved in the pathogenesis of AD, which may be due to the environmental factor rather than genetic factors of the mutations of MTHFR and CBS.