^(99)Tc^m-MIBI心肌断层显像前硝酸甘油评估存活心肌

目的 探讨含服硝酸甘油在介入99Tcm MIBI心肌断层显像在判断心肌存活中的价值。方法 12例心肌梗塞患者先行静息99Tcm MIBI心肌断层显像 ,4 8h后在静脉注射99Tcm MIBI前 5min舌下含服硝酸甘油 0 .5mg ,然后再行静息心肌断层显像 ,观察灌注情况。 结果 12例心肌梗塞患者静息心肌断层显像有 6 8个节段放射性分布异常 ,含服硝酸甘油介入后 2 6个节段灌注改善 ;4 2个节段无变化或有异常加重。结论 含服硝酸甘油在介入99Tcm MIBII心肌断层显像对判断心肌存活有一定的临床价值 ,且方法简便易行 ,安全可靠。

去甲肾上腺素和新福林对硝酸甘油舒血管效应的不同影响

用来自同一大鼠胸主动脉的不同动脉环，比较了用ＮＥ，Ｐｈｅ和Ｋ￣＋作收缩剂时ＧＴＮ的舒血管量效曲线。３×１０ｍｏｌ／Ｌ的ＮＥ，１０￣（－６）ｍｏｌ／Ｌ的Ｐｈｅ和１２４ｍｍｏｌ／Ｌ的Ｋ￣＋收缩血管时ＧＴＮ的量效曲线均为双相Ｓ形。尽管Ｐｈｅ和ＮＥ收缩离体血管的效能大致相同，但ＮＥ收缩的血管环难以被ＧＴＮ所舒张。用Ｋ￣＋作收缩剂时，高浓度的ＧＴＮ不易舒张血管环，而低浓度ＧＴＮ的舒血管作用不受影响。结果表明：ＧＴＮ可能通过两种不同的机制扩张血管；收缩剂类别的差异是ＧＴＮ舒血管量效曲线ＥＣ５０值相差较大的一个重要因素。

Prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography pancreatitis:A randomized placebo-controlled trial

AIM:To examine the prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis and hyperamylasemia.METHODS:Patients scheduled for ERCP were randomly divided into study group and placebo group.Patients in study group and placebo group were treated with 5 mg glyceryl trinitrate and 100 mg vitamin C,respectively,5 min before endoscopic maneuvers.RESULTS:A total of 74 patients were enrolled in the final analysis.Post-ERCP pancreatitis occurred in 3 patients(7.9%) of the study group and 9 patients(25%) in the placebo group(P = 0.012).Hyperamylasemia occurred in 8 patients of the study group(21.1%) and 13 patients(36.1%) of the placebo group(P = 0.037).CONCLUSION:Glyceryl trinitrate before ERCP can effectively prevent post-ERCP and hyperamylasemia.