目的应用Meta分析法系统评价桂枝甘草龙骨牡蛎汤治疗室性早搏的临床疗效及安全性。方法通过计算机检索CBM、PubMed、中国知网、维普、万方等中英文数据库,检索时限为建库至2020年7月,检索关于桂枝甘草龙骨牡蛎汤治疗室性早搏的临床随机...目的应用Meta分析法系统评价桂枝甘草龙骨牡蛎汤治疗室性早搏的临床疗效及安全性。方法通过计算机检索CBM、PubMed、中国知网、维普、万方等中英文数据库,检索时限为建库至2020年7月,检索关于桂枝甘草龙骨牡蛎汤治疗室性早搏的临床随机对照研究文献,经过文献筛选和质量评价提取有效研究,应用Rev Man 5.4分析软件对纳入文献进行Meta分析。结果经筛选最终本研究共纳入13篇临床随机对照研究,均为中文文献,总计1123例样本。Meta分析结果显示:与对照组相比,实验组的总有效率更高[RR=1.19,95%CI(1.13,1.25),P<0.000 01],室早发生总次数[MD=-359.21,95%CI(-749.97,128.03),P=0.02],中医证候积分[MD=-7.26,95%CI(-9.58,-4.93),P=0.02],不良反应发生率[RR=0.39,95%CI(0.25,0.61),P<0.000 1]更低。结论桂枝甘草龙骨牡蛎汤治疗室性早搏具有较好的临床疗效及安全性,所纳入文献总体质量偏低,因此仍需更多的大样本、多中心的随机对照试验提供更多的循证依据。展开更多
Heavy metal pollution has become a worldwide problem in aquaculture. We studied copper （Cu^2＋） accumulation and physiological responses of two red algae Gracilaria lemaneiformis and Gracilaria lichenoides from Chin...Heavy metal pollution has become a worldwide problem in aquaculture. We studied copper （Cu^2＋） accumulation and physiological responses of two red algae Gracilaria lemaneiformis and Gracilaria lichenoides from China under Cu^2＋ exposure of 0-500 μg/L in concentration. Compared with G. lemaneiformis, G. lichenoides was more capable in accumulating Cu^2＋, specifically, more Cu〉 on extracellular side （cell wall） than on intracellular side （cytoplasm） and in cell organelles （especially chloroplast, cell nucleus, mitochondria, and ribosome）. In addition, G. lichenoides contained more insoluble polysaccharide in cell wall, which might promote the extracellular Cu^2＋-binding as an efficient barrier against metal toxicity. Conversely, G. lemaneiformis was more vulnerable than G. lichenoides to Cu^2＋ toxin for decreases in growth, pigment （chlorophyll a, chlorophyll b, phycobiliprotein, and B-carotene） content, and photosynthetic activity. Moreover, more serious oxidative damages in G. lemaneiformis than in G. lichenoides, in accumulation of reactive oxidative species and malondialdehyde, and in electrolyte leakage, because of lower antioxidant enzyme （superoxide dismutase and glutathione reductase） activities. Therefore, G. lichenoides was less susceptible to Cu〉 stress than G. lemaneiformis.展开更多
最近连大牌设计都开始走小清新路线。IKEA图录刚被Graphics Award评为年度最佳(Graphics Award Winner2011)。主题正是"Homemade is Best(家里做的才是最好)"。瑞典著名双人组合公司Forsman &Bodenfors为IKEA设计的"...最近连大牌设计都开始走小清新路线。IKEA图录刚被Graphics Award评为年度最佳(Graphics Award Winner2011)。主题正是"Homemade is Best(家里做的才是最好)"。瑞典著名双人组合公司Forsman &Bodenfors为IKEA设计的"Homemade isBest"烹饪图录和对其忠诚跨国客户15年庆制作的iPhone app产品同时被GraphicsAward的David Kester提名,前者毋庸置疑出位获胜。作为同为瑞典品牌的IKEA2011年大营销计划一部分,Forsman&Bodenfors认识到新宜家厨房真正激动人心之处;"它将消费者对生活的想法植入厨房,餐桌将被个体思考驾驭。""Homemade is Best"系列以创新、时尚的方式呈现了30种食谱配方,灵感源自日式极简主义。原材料被小心翼翼的摆上桌面,组成一幅幅乖巧迷人的涂鸦画。瑞典式烘烤界首次迎来如此色彩丰盛。展开更多
The Yangouxia dinosaur tracksites are well known for a diverse assemblage of tetrapod tracks preserved as natural impressions （concave epireliefs） on large bedding planes, representing a locally widespread surface m...The Yangouxia dinosaur tracksites are well known for a diverse assemblage of tetrapod tracks preserved as natural impressions （concave epireliefs） on large bedding planes, representing a locally widespread surface marking the transition from a sand- to a mud-dominated sequence in the Hekou Group. Previous ichnological studies at these large sites have focused on the morphology and ichnotaxonomy of the tracks, including a single trackway representing the first pterosaur tracks reported from China. Here, we report a distinctly different assemblage associated with minor sandstones in the mud-dominated sequence 20 m above the main tracksite level. This assemblage consists of at least 20 pterosaur manus track casts attributed to a single ichnotaxon （Pteraichnus）. No pes tracks have been identified. These tracks mostly occur in random orientations, although one possible trackway segment is inferred, to represent walking progression.Manus-only pterosaur track assemblages are common and likely reflect differential registration depths of manus and pes and/or sub optimal preservation conditions. The tracks are associated with distinctive invertebrate traces including Cochlichnus, Spongeliomorpha and Paleophycus and suggest the pterosaurs were likely feeding on the invertebrate tracemakers.展开更多
文摘目的应用Meta分析法系统评价桂枝甘草龙骨牡蛎汤治疗室性早搏的临床疗效及安全性。方法通过计算机检索CBM、PubMed、中国知网、维普、万方等中英文数据库,检索时限为建库至2020年7月,检索关于桂枝甘草龙骨牡蛎汤治疗室性早搏的临床随机对照研究文献,经过文献筛选和质量评价提取有效研究,应用Rev Man 5.4分析软件对纳入文献进行Meta分析。结果经筛选最终本研究共纳入13篇临床随机对照研究,均为中文文献,总计1123例样本。Meta分析结果显示:与对照组相比,实验组的总有效率更高[RR=1.19,95%CI(1.13,1.25),P<0.000 01],室早发生总次数[MD=-359.21,95%CI(-749.97,128.03),P=0.02],中医证候积分[MD=-7.26,95%CI(-9.58,-4.93),P=0.02],不良反应发生率[RR=0.39,95%CI(0.25,0.61),P<0.000 1]更低。结论桂枝甘草龙骨牡蛎汤治疗室性早搏具有较好的临床疗效及安全性,所纳入文献总体质量偏低,因此仍需更多的大样本、多中心的随机对照试验提供更多的循证依据。
基金Supported by the Society Development Program of the Natural Science Foundation of Jiangsu Province in China (No.BS2002016)
文摘Heavy metal pollution has become a worldwide problem in aquaculture. We studied copper （Cu^2＋） accumulation and physiological responses of two red algae Gracilaria lemaneiformis and Gracilaria lichenoides from China under Cu^2＋ exposure of 0-500 μg/L in concentration. Compared with G. lemaneiformis, G. lichenoides was more capable in accumulating Cu^2＋, specifically, more Cu〉 on extracellular side （cell wall） than on intracellular side （cytoplasm） and in cell organelles （especially chloroplast, cell nucleus, mitochondria, and ribosome）. In addition, G. lichenoides contained more insoluble polysaccharide in cell wall, which might promote the extracellular Cu^2＋-binding as an efficient barrier against metal toxicity. Conversely, G. lemaneiformis was more vulnerable than G. lichenoides to Cu^2＋ toxin for decreases in growth, pigment （chlorophyll a, chlorophyll b, phycobiliprotein, and B-carotene） content, and photosynthetic activity. Moreover, more serious oxidative damages in G. lemaneiformis than in G. lichenoides, in accumulation of reactive oxidative species and malondialdehyde, and in electrolyte leakage, because of lower antioxidant enzyme （superoxide dismutase and glutathione reductase） activities. Therefore, G. lichenoides was less susceptible to Cu〉 stress than G. lemaneiformis.
文摘最近连大牌设计都开始走小清新路线。IKEA图录刚被Graphics Award评为年度最佳(Graphics Award Winner2011)。主题正是"Homemade is Best(家里做的才是最好)"。瑞典著名双人组合公司Forsman &Bodenfors为IKEA设计的"Homemade isBest"烹饪图录和对其忠诚跨国客户15年庆制作的iPhone app产品同时被GraphicsAward的David Kester提名,前者毋庸置疑出位获胜。作为同为瑞典品牌的IKEA2011年大营销计划一部分,Forsman&Bodenfors认识到新宜家厨房真正激动人心之处;"它将消费者对生活的想法植入厨房,餐桌将被个体思考驾驭。""Homemade is Best"系列以创新、时尚的方式呈现了30种食谱配方,灵感源自日式极简主义。原材料被小心翼翼的摆上桌面,组成一幅幅乖巧迷人的涂鸦画。瑞典式烘烤界首次迎来如此色彩丰盛。
基金supported by the Liujiaxia Dinosaurs National Geoparkthe 2013 Supporting Fund for Graduate Student’s Science and Technology Innovation from China University of Geosciences(Beijing),China
文摘The Yangouxia dinosaur tracksites are well known for a diverse assemblage of tetrapod tracks preserved as natural impressions （concave epireliefs） on large bedding planes, representing a locally widespread surface marking the transition from a sand- to a mud-dominated sequence in the Hekou Group. Previous ichnological studies at these large sites have focused on the morphology and ichnotaxonomy of the tracks, including a single trackway representing the first pterosaur tracks reported from China. Here, we report a distinctly different assemblage associated with minor sandstones in the mud-dominated sequence 20 m above the main tracksite level. This assemblage consists of at least 20 pterosaur manus track casts attributed to a single ichnotaxon （Pteraichnus）. No pes tracks have been identified. These tracks mostly occur in random orientations, although one possible trackway segment is inferred, to represent walking progression.Manus-only pterosaur track assemblages are common and likely reflect differential registration depths of manus and pes and/or sub optimal preservation conditions. The tracks are associated with distinctive invertebrate traces including Cochlichnus, Spongeliomorpha and Paleophycus and suggest the pterosaurs were likely feeding on the invertebrate tracemakers.
