Background. Growing teratoma syndrome (GTS) is defined as enlarging peritoneal implants that occur during or after chemotherapy for malignant germ cell tumors, but are histologically mature teratomas without any malig...Background. Growing teratoma syndrome (GTS) is defined as enlarging peritoneal implants that occur during or after chemotherapy for malignant germ cell tumors, but are histologically mature teratomas without any malignant components. GTS is a synonym for “chemotherapeutic retroconversion", i.e., conversion from a metastatic immature teratoma to a mature tumor by chemotherapy. Gliomatosis peritonei (GP) is a rare condition associated with ovarian teratomas of any grade, in which benign glial implants develop on the peritoneal surface. Case. We present a case of a 34-year-old woman with GTS. Conclusions. Present case supported by review of the literatures suggests that GTS can be a part of GP, because both GTS and GP are associated with benign peritoneal glial implants regardless of grade of malignancy of their original tumor.展开更多
Despite that advances in neonatal medicine have significantly reduced the earl y mortality of premature infants, a considerable number of them are still prone to develop chronic lung disease (CLD) later. To find a met...Despite that advances in neonatal medicine have significantly reduced the earl y mortality of premature infants, a considerable number of them are still prone to develop chronic lung disease (CLD) later. To find a method of early preventio n, we investigated the efficacy of using certain early proinflammatory responses to predict the development of CLD. In the present study, 34 premature infants w ho required endotracheal intubation within 4 h of birth were recruited for analy sis of IL-8, IL-10, and TNF-αlevels in their bronchoalveolar lavage (BAL) fl uid and blood. It was found that level of IL-8 but not TNF-αor IL-10 in init ial BAL fluid was significantly correlated to neutrophils in the BAL and inverse ly correlated to the gestational age of prematurity. Elevation of IL-8 level in BAL on the first day of life was correlated to the development of CLD. Further studies showed that neonatal cord blood released significantly higher IL-8 but lower TNF-αlevels after stimulation by endotoxin. The augmented IL-8 mRNA exp ression in cord blood was inhibited by actinomycin D but enhanced by cycloheximi de, suggesting that IL-8 production is controlled by de novo transcriptional in duction as well as posttranscriptional up-regulation of IL-8 by neonatal leuko cytes, relating to the development of CLD. Thus, an appropriate modulation of in itial IL-8 production in premature infants might be beneficial for the preventi on of the development of CLD.展开更多
文摘Background. Growing teratoma syndrome (GTS) is defined as enlarging peritoneal implants that occur during or after chemotherapy for malignant germ cell tumors, but are histologically mature teratomas without any malignant components. GTS is a synonym for “chemotherapeutic retroconversion", i.e., conversion from a metastatic immature teratoma to a mature tumor by chemotherapy. Gliomatosis peritonei (GP) is a rare condition associated with ovarian teratomas of any grade, in which benign glial implants develop on the peritoneal surface. Case. We present a case of a 34-year-old woman with GTS. Conclusions. Present case supported by review of the literatures suggests that GTS can be a part of GP, because both GTS and GP are associated with benign peritoneal glial implants regardless of grade of malignancy of their original tumor.
文摘Despite that advances in neonatal medicine have significantly reduced the earl y mortality of premature infants, a considerable number of them are still prone to develop chronic lung disease (CLD) later. To find a method of early preventio n, we investigated the efficacy of using certain early proinflammatory responses to predict the development of CLD. In the present study, 34 premature infants w ho required endotracheal intubation within 4 h of birth were recruited for analy sis of IL-8, IL-10, and TNF-αlevels in their bronchoalveolar lavage (BAL) fl uid and blood. It was found that level of IL-8 but not TNF-αor IL-10 in init ial BAL fluid was significantly correlated to neutrophils in the BAL and inverse ly correlated to the gestational age of prematurity. Elevation of IL-8 level in BAL on the first day of life was correlated to the development of CLD. Further studies showed that neonatal cord blood released significantly higher IL-8 but lower TNF-αlevels after stimulation by endotoxin. The augmented IL-8 mRNA exp ression in cord blood was inhibited by actinomycin D but enhanced by cycloheximi de, suggesting that IL-8 production is controlled by de novo transcriptional in duction as well as posttranscriptional up-regulation of IL-8 by neonatal leuko cytes, relating to the development of CLD. Thus, an appropriate modulation of in itial IL-8 production in premature infants might be beneficial for the preventi on of the development of CLD.
