AIM to evaluate gender differences in the aspect of ghrelin,nociception-related genes and psychological aspects and the quality of life(Qo L) in Korean functional dyspepsia(FD) patients.METHODS Total of 191 persons we...AIM to evaluate gender differences in the aspect of ghrelin,nociception-related genes and psychological aspects and the quality of life(Qo L) in Korean functional dyspepsia(FD) patients.METHODS Total of 191 persons were prospectively enrolled between March 2013 and May 2016 in Seoul National Bundang Hospital,and classified into control and FD group based on ROME Ⅲ criteria. Questionnaire included assessment for dyspepsia symptoms,Qo L and anxiety or depression. Preproghrelin and nociception genes in the gastric mucosa and plasma acyl/des-acyl ghrelin were measured. RESULTS Lower level of plasma acyl ghrelin in FD patients compared to control was significant only in male(15.9 fmol/m L vs 10.4 fmol/m L,P = 0.017). Significantly higher m RNA expressions of nerve growth factor and transient receptor potential vanilloid receptor 1 were observed in male(P = 0.002 and P = 0.014,respectively) than in female. In contrast,female FD patients had a higher anxiety and depression score than male FD(P = 0.029),and anxiety score was correlated with epigastric pain only in female FD patients(female: Spearman rho = 0.420,P = 0.037). The impairment of overall Qo L was more prominent in female FD patients than male patients(5.4 ± 0.3 vs 6.5 ± 0.3,P = 0.020). CONCLUSION Gender differences of ghrelin and nociception-related genes in male and psychological factors in female underlie FD symptoms. More careful assessment of psychological or emotional status is required particularly for the female FD patients.展开更多
This study explores the intricate situation of the coexistence of different identities in Amin Maalouf＇ s Ports of Call （1996）. It contends that identity is complex, flux, and not limited to what is inherited; it i...This study explores the intricate situation of the coexistence of different identities in Amin Maalouf＇ s Ports of Call （1996）. It contends that identity is complex, flux, and not limited to what is inherited; it is rather a psychological, political, and social amalgamation. Thus, each individual has a unique and particular identity, which is completely different from the others＇. This study is a theoretical and analytical survey of Maalouf＇s Ports of Call. It aims at proving that this novel is an example that Maalouf provides to show the challenges that characters of different identities face, and the obstacles that hinder them from assimilation. The argument is mainly based on Edward Said＇s theories that have opened up discussions about Otherness and multiculturalism, alongside with other postcolonial critics, such as Homi Bhabha. Maalouf＇s book In the Name of Identity： Violence and the Need to Belong （1996） is also integral to this study. The study concludes that it might be possible for people, in parallel with the characters of the novel, to challenge the identity predicament that the world is witnessing nowadays, and accept diversities as a way of life, rather than a reason for waging wars.展开更多
基金Supported by Support Program for Women in Science,Engineering and Technology through the National Research Foundation of Korea funded by the Ministry of Science,ICT and Future Planning,no.2016H1C3A1903202
文摘AIM to evaluate gender differences in the aspect of ghrelin,nociception-related genes and psychological aspects and the quality of life(Qo L) in Korean functional dyspepsia(FD) patients.METHODS Total of 191 persons were prospectively enrolled between March 2013 and May 2016 in Seoul National Bundang Hospital,and classified into control and FD group based on ROME Ⅲ criteria. Questionnaire included assessment for dyspepsia symptoms,Qo L and anxiety or depression. Preproghrelin and nociception genes in the gastric mucosa and plasma acyl/des-acyl ghrelin were measured. RESULTS Lower level of plasma acyl ghrelin in FD patients compared to control was significant only in male(15.9 fmol/m L vs 10.4 fmol/m L,P = 0.017). Significantly higher m RNA expressions of nerve growth factor and transient receptor potential vanilloid receptor 1 were observed in male(P = 0.002 and P = 0.014,respectively) than in female. In contrast,female FD patients had a higher anxiety and depression score than male FD(P = 0.029),and anxiety score was correlated with epigastric pain only in female FD patients(female: Spearman rho = 0.420,P = 0.037). The impairment of overall Qo L was more prominent in female FD patients than male patients(5.4 ± 0.3 vs 6.5 ± 0.3,P = 0.020). CONCLUSION Gender differences of ghrelin and nociception-related genes in male and psychological factors in female underlie FD symptoms. More careful assessment of psychological or emotional status is required particularly for the female FD patients.
文摘This study explores the intricate situation of the coexistence of different identities in Amin Maalouf＇ s Ports of Call （1996）. It contends that identity is complex, flux, and not limited to what is inherited; it is rather a psychological, political, and social amalgamation. Thus, each individual has a unique and particular identity, which is completely different from the others＇. This study is a theoretical and analytical survey of Maalouf＇s Ports of Call. It aims at proving that this novel is an example that Maalouf provides to show the challenges that characters of different identities face, and the obstacles that hinder them from assimilation. The argument is mainly based on Edward Said＇s theories that have opened up discussions about Otherness and multiculturalism, alongside with other postcolonial critics, such as Homi Bhabha. Maalouf＇s book In the Name of Identity： Violence and the Need to Belong （1996） is also integral to this study. The study concludes that it might be possible for people, in parallel with the characters of the novel, to challenge the identity predicament that the world is witnessing nowadays, and accept diversities as a way of life, rather than a reason for waging wars.
