In the current scenario of global competition and short product life cycles, customer-defined satisfaction has attracted interest in artifact design. Accordingly, intelligent decision-making through multi-objective op...In the current scenario of global competition and short product life cycles, customer-defined satisfaction has attracted interest in artifact design. Accordingly, intelligent decision-making through multi-objective optimization has been proposed as an efficient method for human-centered manufacturing. However, previous vast researches on optimization have been mainly focused on optimization theory and optimization techniques and paid little interests on the process of problem formulation itself. In this paper, therefore, the authors present a total framework for supporting multi-objective decision making. Then, the authors try to solve the formulated multi-objective optimization problem that involves both qualitative and quantitative performance measures as a general consequence from the above procedure. Taking especially quality as a qualitative measure, the authors gave a new idea to evaluate the quality quantitatively. Additionally, to facilitate the portability of the proposed method in multidisciplinary decision-making environments, the authors implement the proposal algorithm in an Excel spreadsheet and validate the effectiveness of the approach through a case study.展开更多
MicroRNAs(miRNAs) are small non-coding RNAs that regulate a variety of biological processes. miRNA expression often exhibits spatial and temporal specificity. However, genome-wide miRNA expression patterns in differen...MicroRNAs(miRNAs) are small non-coding RNAs that regulate a variety of biological processes. miRNA expression often exhibits spatial and temporal specificity. However, genome-wide miRNA expression patterns in different organs during development of Arabidopsis thaliana have not yet been systemically investigated. In this study, we sequenced small RNA libraries generated from 27 different organ/tissue types, which cover the entire life cycle of Arabidopsis. Analysis of the sequencing data revealed that most miRNAs are ubiquitously expressed, whereas a small set of miRNAs display highly specific expression patterns. In addition, different miRNA members within the same family have distinct spatial and temporal expression patterns. Moreover, we found that some miRNAs are produced from different arms of their hairpin precursors at different developmental stages. This work provides new insights into the regulation of miRNA biogenesis and a rich resource for future investigation of miRNA functions in Arabidopsis.展开更多
文摘In the current scenario of global competition and short product life cycles, customer-defined satisfaction has attracted interest in artifact design. Accordingly, intelligent decision-making through multi-objective optimization has been proposed as an efficient method for human-centered manufacturing. However, previous vast researches on optimization have been mainly focused on optimization theory and optimization techniques and paid little interests on the process of problem formulation itself. In this paper, therefore, the authors present a total framework for supporting multi-objective decision making. Then, the authors try to solve the formulated multi-objective optimization problem that involves both qualitative and quantitative performance measures as a general consequence from the above procedure. Taking especially quality as a qualitative measure, the authors gave a new idea to evaluate the quality quantitatively. Additionally, to facilitate the portability of the proposed method in multidisciplinary decision-making environments, the authors implement the proposal algorithm in an Excel spreadsheet and validate the effectiveness of the approach through a case study.
基金supported by grants fromNational Key Research and Development Program of China (2016YFA0500800)National Natural Science Foundation of China (31421001, 31225015) to Yijun Qi
文摘MicroRNAs(miRNAs) are small non-coding RNAs that regulate a variety of biological processes. miRNA expression often exhibits spatial and temporal specificity. However, genome-wide miRNA expression patterns in different organs during development of Arabidopsis thaliana have not yet been systemically investigated. In this study, we sequenced small RNA libraries generated from 27 different organ/tissue types, which cover the entire life cycle of Arabidopsis. Analysis of the sequencing data revealed that most miRNAs are ubiquitously expressed, whereas a small set of miRNAs display highly specific expression patterns. In addition, different miRNA members within the same family have distinct spatial and temporal expression patterns. Moreover, we found that some miRNAs are produced from different arms of their hairpin precursors at different developmental stages. This work provides new insights into the regulation of miRNA biogenesis and a rich resource for future investigation of miRNA functions in Arabidopsis.
