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生命大科学:从微观到介观的组学研究
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作者 吴家睿 《中国科学院院刊》 CSSCI CSCD 北大核心 2024年第5期832-839,共8页
世纪之交的“人类基因组计划”开启了生命大科学的研究新时代,形成了以整体性高通量研究为特征的各种生命组学。最初的组学研究主要在分子层次上展开,如基因组学、转录组学、蛋白质组学等,表现出数据驱动的研究新范式。随着研究技术的发... 世纪之交的“人类基因组计划”开启了生命大科学的研究新时代,形成了以整体性高通量研究为特征的各种生命组学。最初的组学研究主要在分子层次上展开,如基因组学、转录组学、蛋白质组学等,表现出数据驱动的研究新范式。随着研究技术的发展,组学研究上升到介观层次,其核心是2017年启动的“人类细胞图谱”计划。目前,研究者已经能够在组织器官乃至个体水平开展组学研究,通过整合不同层次的组学数据来认识生命复杂系统。 展开更多
关键词 生命大科学 组学 细胞图谱 空间组学 大数据
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The Universal Grand Unified Theory Based on Life and Thought 被引量:1
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作者 Jinzhong Yan 《Journal of Physical Science and Application》 2015年第2期147-157,共11页
The universe is life, which includes galaxies, living beings, society and man-made worlds. The universe is unified in life and thought. The universal grand unified theory is a theory to completely unify all phenomena ... The universe is life, which includes galaxies, living beings, society and man-made worlds. The universe is unified in life and thought. The universal grand unified theory is a theory to completely unify all phenomena in the universe with a fundamental mode (structural mode, operational mode, generation mode and evolution mode). The book of changes of China: The great ultimate - two states - four images - eight hexagrams are life science and thought science theories, which represent the fundamental mode of universal unification, i.e. represent l) structural mode, operational mode, generation mode and evolution mode of life; 2) the four states that life has simultaneously: 0 dimension, ] dimension, 2 dimension, 3 dimension, and these four states have different structural and operational modes respectively; 3) the breathing and four seasonal trajectories of celestial bodies; 4) three generation modes of life: generation by transformation, generation by augmentation, and self-generation; 5) five dynamics systems inside life; 6) the sublimation and degration of life in the universe, the unification of religion and science; 7) the classification mode of the universal being; 8) the derivation mode of life; 9) the transformation between different forms of life in the universe; 10) the unification of six grand forces in the universe. All life systems in the universe: galaxy, organism, society, man-made worlds as well as cognitive science, natural science, social science are all in conform with the mode of the book of changes. 展开更多
关键词 The book of changes LIFE THOUGHT UNIVERSE grand unified theory.
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Lifeomics leads the age of grand discoveries 被引量:8
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作者 HE FuChu 《Science China(Life Sciences)》 SCIE CAS 2013年第3期201-212,共12页
When our knowledge of a field accumulates to a certain level,we are bound to see the rise of one or more great scientists.They will make a series of grand discoveries/breakthroughs and push the discipline into an '... When our knowledge of a field accumulates to a certain level,we are bound to see the rise of one or more great scientists.They will make a series of grand discoveries/breakthroughs and push the discipline into an 'age of grand discoveries'.Mathematics,geography,physics and chemistry have all experienced their ages of grand discoveries;and in life sciences,the age of grand discoveries has appeared countless times since the 16th century.Thanks to the ever-changing development of molecular biology over the past 50 years,contemporary life science is once again approaching its breaking point and the trigger for this is most likely to be 'lifeomics'.At the end of the 20th century,genomics wrote out the 'script of life';proteomics decoded the script;and RNAomics,glycomics and metabolomics came into bloom.These 'omics',with their unique epistemology and methodology,quickly became the thrust of life sciences,pushing the discipline to new high.Lifeomics,which encompasses all omics,has taken shape and is now signalling the dawn of a new era,the age of grand discoveries. 展开更多
关键词 age of grand discoveries lifeomics life sciences
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A key link between jasmonic acid signaling and auxin biosynthesis 被引量:1
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作者 HE YuBing ZHAO Yunde 《Science China(Life Sciences)》 SCIE CAS CSCD 2015年第3期311-312,共2页
A research team led by Xiang Cheng Bin from School of Life Sciences,University of Science and Technology of China discovered a molecular basis for crosstalk between jasmonic acid(JA)and auxin,two important plant hor... A research team led by Xiang Cheng Bin from School of Life Sciences,University of Science and Technology of China discovered a molecular basis for crosstalk between jasmonic acid(JA)and auxin,two important plant hormones.Their findings were published in a recent issue of Nature Communication[1].Auxin is the plant growth hormone that plays an essential 展开更多
关键词 auxin crosstalk biosynthesis Xiang hormones Arabidopsis drought signaling abiotic roots
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