The prokaryotic and eukaryotic cells of the colon exist in a highly complex, but harmonious relationship. Disturbances in this remarkable symbiosis can result in the development of inflammatory bowel diseases (IBD). A...The prokaryotic and eukaryotic cells of the colon exist in a highly complex, but harmonious relationship. Disturbances in this remarkable symbiosis can result in the development of inflammatory bowel diseases (IBD). Although the etiology of IBD is not entirely understood, it is known that the chronic inflammation of Crohn’s disease, ulcerative colitis and chronic pouchitis are a result of an overly aggressive immune response to the commensal intestinal flora in genetically susceptible hosts. Recent studies have enhanced our ability to understand the interaction between the host and its intestinal microflora and the role the microflora plays in maintaining intestinal homeostasis. As we begin to understand the benefi ts conferred to the intestine by the microflora, the notion of modifying the composition of the bacterial load to improve human health has arisen. A signifi cant body of research now exists investigating the role of probiotics and prebiotics in ameliorating chronic intestinal inflammation. This article will begin with an overview of the role of the commensal microflora in maintaining mucosal immune homeostasis, and how a dysregulated immune response to the intestinal microflora results in IBD. This will be followed by a summary of the use of probiotics and prebiotics in experimental and human IBD.展开更多
The cytotoxicity of abamectin to the Gill Cell Line of Flounder （FG cell line） was examined in this study. It was found that the exposure of FG cells to abamectin caused the decreases of both cell growth rate and an...The cytotoxicity of abamectin to the Gill Cell Line of Flounder （FG cell line） was examined in this study. It was found that the exposure of FG cells to abamectin caused the decreases of both cell growth rate and antioxidant enzyme activities, and the increase of intracellular 02 content. It was proposed that the reduction of antioxidant enzyme activities in FG cells caused the accumulation of 02 content in FG cells, leading to the change of cell morphology and even the death of cells. The results showed that FG cell line is suitable for the evaluation of the acute toxicity of abamectin.展开更多
The spatio-temporal patterns of macrofaunal fouling assemblages were quantitatively investigated in the nearshore waters of the South China Sea.The work was undertaken by deploying seasonal panels at two sites(H-site,...The spatio-temporal patterns of macrofaunal fouling assemblages were quantitatively investigated in the nearshore waters of the South China Sea.The work was undertaken by deploying seasonal panels at two sites(H-site,L-site) for one year,and the fouling communities on the panels were examined and analyzed.The results indicated that species composition of assemblages was obviously different between the two sites.At both sites the assemblages were characteristic with solitary dominant species throughout the year,with Amphibalanus reticulates dominating at H-site and Hydroides elegans at L-site.Shannon index and biomass of the assemblages varied with depth and season at both sites.At H-site the total biomass in summer and autumn were significantly higher than those in spring and winter,while at L-site the assemblage biomass also differed significantly among the four seasons,and the greatest biomass occurred at the depth of 2.0 m in winter.The abundance of all seasonal samples in non-metric multidimensional scaling was clustered as one group at L-site and three groups at H-site.The environmental factors were more likely to be related to the variation of fouling assemblages.Furthermore,it also suggests that in tropical seas the integrated adaptability would qualify a species for dominating a fouling assemblage despite its short life cycle,rather than the usually assumed only species with long life span.This study reveals the complexity and characteristic dynamics of macrofaunal fouling assemblages in the tropical habitats,and the results would provide valuable knowledge for biodiversity and antifouling research.展开更多
Personal ethics are strongly influenced by emotions, particularly secondary emotions, because these emotions expand ethical reasoning and development as the child matures. A well-developed consciousness profoundly inf...Personal ethics are strongly influenced by emotions, particularly secondary emotions, because these emotions expand ethical reasoning and development as the child matures. A well-developed consciousness profoundly influences a person＇s actions and conduct when solving problems of what is thought, or taught to be, right or wrong Compelling neurological evidence supports the claim that children begin to develop enduring ethical standards at an early age and that these standards are largely based on the experiences of early childhood. Essentially, the innate sense of ethics requires nurturing during infancy before it can be cognitively understood and practiced in maturity. In biological terms, the development of neural networks that regulate emotional growth, and subsequently, the capacity for ethical discrimination, depends on the infant＇s early social environment. Thus, the toddler＇s early epigenetic experiences enhance, or impede, its innate still dormant genetic potential. Importantly, personal character development and ethical discrimination begins long before the child＇s formal educational years. As a consequence, early learning has to discover ways of conserving adaptive thinking which can be applied to the choices that may confront future generations. Early ethics education, including accurate access to scientific, medical, and technological knowledge, is thus critical. Future generations will increasingly require education from a global perspective when making major ethical decisions in areas, such as nuclear technology, disposal of wastes, preservation of biodiversity, global warming, and unregulated human population growth. As long as our culture continues to reflect advances in science and technology, there is an obligation to make science education overlap with crucial periods in the advancement of ethical consciousness. Significantly, when considering the human capacity for excess at times of conflict, it is incumbent on the scientific community to integrate research-based knowledge with wide-ranging learning and problem-solving skills. Bioscience ethics, the established interface bridging applied science and applied bioethics, can assist in this process of integration. To become fully responsible adults, we must share our extraordinary cognitive talents and respect life on earth in all its rich diversity. In biological terms, human uniqueness resides primarily in our brains with its products being co-operation in family and ancestral units, long education, sophisticated language and culture, and importantly, ethical consciousness-all attributes held in trust by knowledge and wisdom for future generations.展开更多
Rapid developments in both fundamental science and modern technology that target water-related problems, including the physical nature of our planet and environment, the origin of life, energy production via water spl...Rapid developments in both fundamental science and modern technology that target water-related problems, including the physical nature of our planet and environment, the origin of life, energy production via water splitting, and water purification, all call for a molecular-level understanding of water. This invokes relentless efforts to further our understanding of the basic science of water. Current challenges to achieve a molecular picture of the peculiar properties and behavior of water are discussed herein, with a particular focus on the structure and dynamics of bulk and surface water, the molecular mechanisms of water wetting and splitting, application-oriented research on water decontamination and desalination, and the development of complementary techniques for probing water at the nanoscale.展开更多
With life cycle assessment(LCA) methodology,a life cycle model of coal-based vehicle fuels(CBVFs) including coal-based dimethyl ether(CBDME) and coal-based diesel(CBD) is established.Their primary energy consumption(P...With life cycle assessment(LCA) methodology,a life cycle model of coal-based vehicle fuels(CBVFs) including coal-based dimethyl ether(CBDME) and coal-based diesel(CBD) is established.Their primary energy consumption(PEC) and global warming potential(GWP) from well to wheel including feedstock extraction,fuel production,fuel consumption in vehicle and energy transportation are calculated and compared.Results show that the life cycle PEC and GWP of CBD pathway are 1.17 and 1.34 times as CBDME pathway.Based on the above results,CBDME will become a choice with great potential to replace conventional petroleum-based diesel (CPBD) in China.展开更多
文摘The prokaryotic and eukaryotic cells of the colon exist in a highly complex, but harmonious relationship. Disturbances in this remarkable symbiosis can result in the development of inflammatory bowel diseases (IBD). Although the etiology of IBD is not entirely understood, it is known that the chronic inflammation of Crohn’s disease, ulcerative colitis and chronic pouchitis are a result of an overly aggressive immune response to the commensal intestinal flora in genetically susceptible hosts. Recent studies have enhanced our ability to understand the interaction between the host and its intestinal microflora and the role the microflora plays in maintaining intestinal homeostasis. As we begin to understand the benefi ts conferred to the intestine by the microflora, the notion of modifying the composition of the bacterial load to improve human health has arisen. A signifi cant body of research now exists investigating the role of probiotics and prebiotics in ameliorating chronic intestinal inflammation. This article will begin with an overview of the role of the commensal microflora in maintaining mucosal immune homeostasis, and how a dysregulated immune response to the intestinal microflora results in IBD. This will be followed by a summary of the use of probiotics and prebiotics in experimental and human IBD.
文摘The cytotoxicity of abamectin to the Gill Cell Line of Flounder （FG cell line） was examined in this study. It was found that the exposure of FG cells to abamectin caused the decreases of both cell growth rate and antioxidant enzyme activities, and the increase of intracellular 02 content. It was proposed that the reduction of antioxidant enzyme activities in FG cells caused the accumulation of 02 content in FG cells, leading to the change of cell morphology and even the death of cells. The results showed that FG cell line is suitable for the evaluation of the acute toxicity of abamectin.
基金supported by the National Natural Science Foundation of China(Nos.31660128,31360105 and 31160098)the Hainan University(Nos.kypd 1046 and Hdcxcyxm201715)
文摘The spatio-temporal patterns of macrofaunal fouling assemblages were quantitatively investigated in the nearshore waters of the South China Sea.The work was undertaken by deploying seasonal panels at two sites(H-site,L-site) for one year,and the fouling communities on the panels were examined and analyzed.The results indicated that species composition of assemblages was obviously different between the two sites.At both sites the assemblages were characteristic with solitary dominant species throughout the year,with Amphibalanus reticulates dominating at H-site and Hydroides elegans at L-site.Shannon index and biomass of the assemblages varied with depth and season at both sites.At H-site the total biomass in summer and autumn were significantly higher than those in spring and winter,while at L-site the assemblage biomass also differed significantly among the four seasons,and the greatest biomass occurred at the depth of 2.0 m in winter.The abundance of all seasonal samples in non-metric multidimensional scaling was clustered as one group at L-site and three groups at H-site.The environmental factors were more likely to be related to the variation of fouling assemblages.Furthermore,it also suggests that in tropical seas the integrated adaptability would qualify a species for dominating a fouling assemblage despite its short life cycle,rather than the usually assumed only species with long life span.This study reveals the complexity and characteristic dynamics of macrofaunal fouling assemblages in the tropical habitats,and the results would provide valuable knowledge for biodiversity and antifouling research.
文摘Personal ethics are strongly influenced by emotions, particularly secondary emotions, because these emotions expand ethical reasoning and development as the child matures. A well-developed consciousness profoundly influences a person＇s actions and conduct when solving problems of what is thought, or taught to be, right or wrong Compelling neurological evidence supports the claim that children begin to develop enduring ethical standards at an early age and that these standards are largely based on the experiences of early childhood. Essentially, the innate sense of ethics requires nurturing during infancy before it can be cognitively understood and practiced in maturity. In biological terms, the development of neural networks that regulate emotional growth, and subsequently, the capacity for ethical discrimination, depends on the infant＇s early social environment. Thus, the toddler＇s early epigenetic experiences enhance, or impede, its innate still dormant genetic potential. Importantly, personal character development and ethical discrimination begins long before the child＇s formal educational years. As a consequence, early learning has to discover ways of conserving adaptive thinking which can be applied to the choices that may confront future generations. Early ethics education, including accurate access to scientific, medical, and technological knowledge, is thus critical. Future generations will increasingly require education from a global perspective when making major ethical decisions in areas, such as nuclear technology, disposal of wastes, preservation of biodiversity, global warming, and unregulated human population growth. As long as our culture continues to reflect advances in science and technology, there is an obligation to make science education overlap with crucial periods in the advancement of ethical consciousness. Significantly, when considering the human capacity for excess at times of conflict, it is incumbent on the scientific community to integrate research-based knowledge with wide-ranging learning and problem-solving skills. Bioscience ethics, the established interface bridging applied science and applied bioethics, can assist in this process of integration. To become fully responsible adults, we must share our extraordinary cognitive talents and respect life on earth in all its rich diversity. In biological terms, human uniqueness resides primarily in our brains with its products being co-operation in family and ancestral units, long education, sophisticated language and culture, and importantly, ethical consciousness-all attributes held in trust by knowledge and wisdom for future generations.
基金We thank discussion and help from Chongqin Zhu and Dr. Hui Li, Dr. Z. X. Cao, and Dr. Y. Luo during manuscript preparation. Financial support from NIST, the National Basic Research Program of China （No. 2012CB921403） and the National Natural Science Foundationof China （Nos. 11474328, 11290164, and 11222431） and CAS are gratefully acknowledged.
文摘Rapid developments in both fundamental science and modern technology that target water-related problems, including the physical nature of our planet and environment, the origin of life, energy production via water splitting, and water purification, all call for a molecular-level understanding of water. This invokes relentless efforts to further our understanding of the basic science of water. Current challenges to achieve a molecular picture of the peculiar properties and behavior of water are discussed herein, with a particular focus on the structure and dynamics of bulk and surface water, the molecular mechanisms of water wetting and splitting, application-oriented research on water decontamination and desalination, and the development of complementary techniques for probing water at the nanoscale.
文摘With life cycle assessment(LCA) methodology,a life cycle model of coal-based vehicle fuels(CBVFs) including coal-based dimethyl ether(CBDME) and coal-based diesel(CBD) is established.Their primary energy consumption(PEC) and global warming potential(GWP) from well to wheel including feedstock extraction,fuel production,fuel consumption in vehicle and energy transportation are calculated and compared.Results show that the life cycle PEC and GWP of CBD pathway are 1.17 and 1.34 times as CBDME pathway.Based on the above results,CBDME will become a choice with great potential to replace conventional petroleum-based diesel (CPBD) in China.
