The universe is life, which includes galaxies, living beings, society and man-made worlds. The universe is unified in life and thought. The universal grand unified theory is a theory to completely unify all phenomena ...The universe is life, which includes galaxies, living beings, society and man-made worlds. The universe is unified in life and thought. The universal grand unified theory is a theory to completely unify all phenomena in the universe with a fundamental mode （structural mode, operational mode, generation mode and evolution mode）. The book of changes of China： The great ultimate - two states - four images - eight hexagrams are life science and thought science theories, which represent the fundamental mode of universal unification, i.e. represent l） structural mode, operational mode, generation mode and evolution mode of life; 2） the four states that life has simultaneously： 0 dimension, ] dimension, 2 dimension, 3 dimension, and these four states have different structural and operational modes respectively; 3） the breathing and four seasonal trajectories of celestial bodies; 4） three generation modes of life： generation by transformation, generation by augmentation, and self-generation; 5） five dynamics systems inside life; 6） the sublimation and degration of life in the universe, the unification of religion and science; 7） the classification mode of the universal being; 8） the derivation mode of life; 9） the transformation between different forms of life in the universe; 10） the unification of six grand forces in the universe. All life systems in the universe： galaxy, organism, society, man-made worlds as well as cognitive science, natural science, social science are all in conform with the mode of the book of changes.展开更多
The cytotoxicity of abamectin to the Gill Cell Line of Flounder （FG cell line） was examined in this study. It was found that the exposure of FG cells to abamectin caused the decreases of both cell growth rate and an...The cytotoxicity of abamectin to the Gill Cell Line of Flounder （FG cell line） was examined in this study. It was found that the exposure of FG cells to abamectin caused the decreases of both cell growth rate and antioxidant enzyme activities, and the increase of intracellular 02 content. It was proposed that the reduction of antioxidant enzyme activities in FG cells caused the accumulation of 02 content in FG cells, leading to the change of cell morphology and even the death of cells. The results showed that FG cell line is suitable for the evaluation of the acute toxicity of abamectin.展开更多
Abstract With the development of genome-wide sequencing technology, 195 types of functional long non-coding RNAs （lncRNAs） have so far been found, and their cellular roles are gradually being revealed. Now lncRNAs h...Abstract With the development of genome-wide sequencing technology, 195 types of functional long non-coding RNAs （lncRNAs） have so far been found, and their cellular roles are gradually being revealed. Now lncRNAs have become a hotspot in the life science. These small molecules exist in almost all higher eukaryotes, and have very important regulatory roles in these organisms. This review briefly summarizes recent progress in researches on antisense non-coding RNA in the INK4 locus.展开更多
This paper outlines briefly the role of nuclear medicine in life sciences and health care. Molecular imaging by using isotopic tracers can noninvasively visualize the chemistry or hidden process in the cells and tissu...This paper outlines briefly the role of nuclear medicine in life sciences and health care. Molecular imaging by using isotopic tracers can noninvasively visualize the chemistry or hidden process in the cells and tissues inside the body, obtaining "functional" images to provide early information of any disease and revealing the secrets of life. The vitality of nuclear medicine is its ability to translate bench into new clinical application that can benefits the patients. Although nuclear medicine community in China has made significant achievement with a great effort since 1950s, there are many obstacles to future development. Recommended measures are proposed here in an attempt to solve our existing problems.展开更多
In this paper, we investigate the global behavior of the difference equation xn＋1=1-2n/A＋∑k i=1xn-iwith the A ∈ （-∞,-1） is a real number, k is a positive integer and the initial conditions x_k x0 ∈ （-∞, 0].
Life sciences urban developments are a relatively recent phenomenon, and follow the emergence of knowledge based urban developments as a potential driver of urban regeneration and local economic growth. The role of th...Life sciences urban developments are a relatively recent phenomenon, and follow the emergence of knowledge based urban developments as a potential driver of urban regeneration and local economic growth. The role of these new centres in transforming the inner cities of some of the UK＇s larger conurbations is examined and the key planning issues are discussed. The article concludes that the key principles of urban planning and control must still apply in shaping the role these new developments have in the UK＇s evolving urban landscape.展开更多
In current world, with the rapid development of science and technology and emerging new and interdisciplinary science, technological progress is having extensive and profound impact on the economic and social aspects....In current world, with the rapid development of science and technology and emerging new and interdisciplinary science, technological progress is having extensive and profound impact on the economic and social aspects. Along with the wave of information technology revolution, life sciences and biotechnology are showing the developing prospect of unlimited possibilities. More and more people have foreseen the arrival of a new era of life sciences, which has important impact on science and technology development, social progress and economic growth.展开更多
The present work makes an in-depth analysis of an aspect not yet sufficiently examined by the studies into regional innovation systems, relating to why the policy makers must adopt regional innovation policies in acco...The present work makes an in-depth analysis of an aspect not yet sufficiently examined by the studies into regional innovation systems, relating to why the policy makers must adopt regional innovation policies in accordance with the development cycle of the active clusters in the territory. The analysis carried out in the course of the work contributes towards understanding the validity of an evolutionary-type development model for which the regional innovation policies for the growth of high-tech firms should dynamically change in relation to the various cluster stages. The development model proposed provides a framework for the policy makers in order to state more efficiently through time the regional innovation strategies.展开更多
Personal ethics are strongly influenced by emotions, particularly secondary emotions, because these emotions expand ethical reasoning and development as the child matures. A well-developed consciousness profoundly inf...Personal ethics are strongly influenced by emotions, particularly secondary emotions, because these emotions expand ethical reasoning and development as the child matures. A well-developed consciousness profoundly influences a person＇s actions and conduct when solving problems of what is thought, or taught to be, right or wrong Compelling neurological evidence supports the claim that children begin to develop enduring ethical standards at an early age and that these standards are largely based on the experiences of early childhood. Essentially, the innate sense of ethics requires nurturing during infancy before it can be cognitively understood and practiced in maturity. In biological terms, the development of neural networks that regulate emotional growth, and subsequently, the capacity for ethical discrimination, depends on the infant＇s early social environment. Thus, the toddler＇s early epigenetic experiences enhance, or impede, its innate still dormant genetic potential. Importantly, personal character development and ethical discrimination begins long before the child＇s formal educational years. As a consequence, early learning has to discover ways of conserving adaptive thinking which can be applied to the choices that may confront future generations. Early ethics education, including accurate access to scientific, medical, and technological knowledge, is thus critical. Future generations will increasingly require education from a global perspective when making major ethical decisions in areas, such as nuclear technology, disposal of wastes, preservation of biodiversity, global warming, and unregulated human population growth. As long as our culture continues to reflect advances in science and technology, there is an obligation to make science education overlap with crucial periods in the advancement of ethical consciousness. Significantly, when considering the human capacity for excess at times of conflict, it is incumbent on the scientific community to integrate research-based knowledge with wide-ranging learning and problem-solving skills. Bioscience ethics, the established interface bridging applied science and applied bioethics, can assist in this process of integration. To become fully responsible adults, we must share our extraordinary cognitive talents and respect life on earth in all its rich diversity. In biological terms, human uniqueness resides primarily in our brains with its products being co-operation in family and ancestral units, long education, sophisticated language and culture, and importantly, ethical consciousness-all attributes held in trust by knowledge and wisdom for future generations.展开更多
Wittgenstein in Philosophical Investigations and On Certainty develops a revolutionary conception of knowledge, of philosophy of language, and of philosophy of science. Very close to language-games is a concept that i...Wittgenstein in Philosophical Investigations and On Certainty develops a revolutionary conception of knowledge, of philosophy of language, and of philosophy of science. Very close to language-games is a concept that is important but did not attract much attention, the one of paradigm. In this paper this concept is analyzed together with notions such as context, use, reference, language-games, reality, science, truth, method, propositions, among others by means of which a new view of epistemology emerges. As for Kuhn, paradigm is his most known notion and his biggest contribution to innovate the history of science. I contrast these two conceptions and conclude that they have different uses, and that some difficulties that emerge from Kuhn＇s concept of paradigm would be dissolved if we take into consideration Witt^enstein＇s aooroaches of language and the uses it has in our life forms.展开更多
When our knowledge of a field accumulates to a certain level,we are bound to see the rise of one or more great scientists.They will make a series of grand discoveries/breakthroughs and push the discipline into an '...When our knowledge of a field accumulates to a certain level,we are bound to see the rise of one or more great scientists.They will make a series of grand discoveries/breakthroughs and push the discipline into an 'age of grand discoveries'.Mathematics,geography,physics and chemistry have all experienced their ages of grand discoveries;and in life sciences,the age of grand discoveries has appeared countless times since the 16th century.Thanks to the ever-changing development of molecular biology over the past 50 years,contemporary life science is once again approaching its breaking point and the trigger for this is most likely to be 'lifeomics'.At the end of the 20th century,genomics wrote out the 'script of life';proteomics decoded the script;and RNAomics,glycomics and metabolomics came into bloom.These 'omics',with their unique epistemology and methodology,quickly became the thrust of life sciences,pushing the discipline to new high.Lifeomics,which encompasses all omics,has taken shape and is now signalling the dawn of a new era,the age of grand discoveries.展开更多
Proteomics focuses on the systematic identification and quantification of entire proteomes and interpretation of proteins’biological functions.During the last decade,proteomics in China has grown much faster than oth...Proteomics focuses on the systematic identification and quantification of entire proteomes and interpretation of proteins’biological functions.During the last decade,proteomics in China has grown much faster than other research fields in life sciences.At the beginning of the second decade of the 21st century,the rapid development of high-resolution and high-speed mass spectrometry makes proteomics a powerful tool to study the mechanisms underlying physiological/pathological processes in organisms.This article provides a brief overview of proteomics technology development and representative scientific progress of the Human Liver Proteome Project in China over the past three years.展开更多
The emergence and development of constructal theory,which has been a new discipline branch to research sorts of structures in nature and engineering,are reviewed.The core of the constructal theory is that various shap...The emergence and development of constructal theory,which has been a new discipline branch to research sorts of structures in nature and engineering,are reviewed.The core of the constructal theory is that various shapes and structures of the matters in nature are generated from the tendency to obtain optimal performance.Constructal theory and its application are summarized,from disciplines such as heat,mechanism,fluid flow,electricity,magnetism and chemistry,to life and non-life systems in nature.展开更多
Interests in intracellular peptide delivery have continued to grow,significantly fueled by the importance of peptides and their mimetics in modern cell biology and pharmaceutical industry.However,efficient intracellul...Interests in intracellular peptide delivery have continued to grow,significantly fueled by the importance of peptides and their mimetics in modern cell biology and pharmaceutical industry.However,efficient intracellular delivery of membrane-impermeable peptides of different polarities remains a challenging task.In this study,we develop a general and robust strategy for intracellular peptide delivery by using a boronic acid-rich dendrimer.The designed material is capable of transporting peptides with different polarities and charge properties into the cytosol of various cell lines without inducing additional cytotoxicity.The transduction efficacy and proteolytic stability of cargo peptides delivered by the boronic acid-rich dendrimer are much superior to peptides conjugated with cell penetrant peptides such as octaarginine.In addition,the bioactivities of pro-apoptotic peptides are maintained after intracellular delivery.This study provides a versatile and robust platform for the intracellular delivery of membrane-impermeable peptides.展开更多
文摘The universe is life, which includes galaxies, living beings, society and man-made worlds. The universe is unified in life and thought. The universal grand unified theory is a theory to completely unify all phenomena in the universe with a fundamental mode （structural mode, operational mode, generation mode and evolution mode）. The book of changes of China： The great ultimate - two states - four images - eight hexagrams are life science and thought science theories, which represent the fundamental mode of universal unification, i.e. represent l） structural mode, operational mode, generation mode and evolution mode of life; 2） the four states that life has simultaneously： 0 dimension, ] dimension, 2 dimension, 3 dimension, and these four states have different structural and operational modes respectively; 3） the breathing and four seasonal trajectories of celestial bodies; 4） three generation modes of life： generation by transformation, generation by augmentation, and self-generation; 5） five dynamics systems inside life; 6） the sublimation and degration of life in the universe, the unification of religion and science; 7） the classification mode of the universal being; 8） the derivation mode of life; 9） the transformation between different forms of life in the universe; 10） the unification of six grand forces in the universe. All life systems in the universe： galaxy, organism, society, man-made worlds as well as cognitive science, natural science, social science are all in conform with the mode of the book of changes.
文摘The cytotoxicity of abamectin to the Gill Cell Line of Flounder （FG cell line） was examined in this study. It was found that the exposure of FG cells to abamectin caused the decreases of both cell growth rate and antioxidant enzyme activities, and the increase of intracellular 02 content. It was proposed that the reduction of antioxidant enzyme activities in FG cells caused the accumulation of 02 content in FG cells, leading to the change of cell morphology and even the death of cells. The results showed that FG cell line is suitable for the evaluation of the acute toxicity of abamectin.
文摘Abstract With the development of genome-wide sequencing technology, 195 types of functional long non-coding RNAs （lncRNAs） have so far been found, and their cellular roles are gradually being revealed. Now lncRNAs have become a hotspot in the life science. These small molecules exist in almost all higher eukaryotes, and have very important regulatory roles in these organisms. This review briefly summarizes recent progress in researches on antisense non-coding RNA in the INK4 locus.
文摘This paper outlines briefly the role of nuclear medicine in life sciences and health care. Molecular imaging by using isotopic tracers can noninvasively visualize the chemistry or hidden process in the cells and tissues inside the body, obtaining "functional" images to provide early information of any disease and revealing the secrets of life. The vitality of nuclear medicine is its ability to translate bench into new clinical application that can benefits the patients. Although nuclear medicine community in China has made significant achievement with a great effort since 1950s, there are many obstacles to future development. Recommended measures are proposed here in an attempt to solve our existing problems.
文摘In this paper, we investigate the global behavior of the difference equation xn＋1=1-2n/A＋∑k i=1xn-iwith the A ∈ （-∞,-1） is a real number, k is a positive integer and the initial conditions x_k x0 ∈ （-∞, 0].
文摘Life sciences urban developments are a relatively recent phenomenon, and follow the emergence of knowledge based urban developments as a potential driver of urban regeneration and local economic growth. The role of these new centres in transforming the inner cities of some of the UK＇s larger conurbations is examined and the key planning issues are discussed. The article concludes that the key principles of urban planning and control must still apply in shaping the role these new developments have in the UK＇s evolving urban landscape.
文摘In current world, with the rapid development of science and technology and emerging new and interdisciplinary science, technological progress is having extensive and profound impact on the economic and social aspects. Along with the wave of information technology revolution, life sciences and biotechnology are showing the developing prospect of unlimited possibilities. More and more people have foreseen the arrival of a new era of life sciences, which has important impact on science and technology development, social progress and economic growth.
文摘The present work makes an in-depth analysis of an aspect not yet sufficiently examined by the studies into regional innovation systems, relating to why the policy makers must adopt regional innovation policies in accordance with the development cycle of the active clusters in the territory. The analysis carried out in the course of the work contributes towards understanding the validity of an evolutionary-type development model for which the regional innovation policies for the growth of high-tech firms should dynamically change in relation to the various cluster stages. The development model proposed provides a framework for the policy makers in order to state more efficiently through time the regional innovation strategies.
文摘Personal ethics are strongly influenced by emotions, particularly secondary emotions, because these emotions expand ethical reasoning and development as the child matures. A well-developed consciousness profoundly influences a person＇s actions and conduct when solving problems of what is thought, or taught to be, right or wrong Compelling neurological evidence supports the claim that children begin to develop enduring ethical standards at an early age and that these standards are largely based on the experiences of early childhood. Essentially, the innate sense of ethics requires nurturing during infancy before it can be cognitively understood and practiced in maturity. In biological terms, the development of neural networks that regulate emotional growth, and subsequently, the capacity for ethical discrimination, depends on the infant＇s early social environment. Thus, the toddler＇s early epigenetic experiences enhance, or impede, its innate still dormant genetic potential. Importantly, personal character development and ethical discrimination begins long before the child＇s formal educational years. As a consequence, early learning has to discover ways of conserving adaptive thinking which can be applied to the choices that may confront future generations. Early ethics education, including accurate access to scientific, medical, and technological knowledge, is thus critical. Future generations will increasingly require education from a global perspective when making major ethical decisions in areas, such as nuclear technology, disposal of wastes, preservation of biodiversity, global warming, and unregulated human population growth. As long as our culture continues to reflect advances in science and technology, there is an obligation to make science education overlap with crucial periods in the advancement of ethical consciousness. Significantly, when considering the human capacity for excess at times of conflict, it is incumbent on the scientific community to integrate research-based knowledge with wide-ranging learning and problem-solving skills. Bioscience ethics, the established interface bridging applied science and applied bioethics, can assist in this process of integration. To become fully responsible adults, we must share our extraordinary cognitive talents and respect life on earth in all its rich diversity. In biological terms, human uniqueness resides primarily in our brains with its products being co-operation in family and ancestral units, long education, sophisticated language and culture, and importantly, ethical consciousness-all attributes held in trust by knowledge and wisdom for future generations.
文摘Wittgenstein in Philosophical Investigations and On Certainty develops a revolutionary conception of knowledge, of philosophy of language, and of philosophy of science. Very close to language-games is a concept that is important but did not attract much attention, the one of paradigm. In this paper this concept is analyzed together with notions such as context, use, reference, language-games, reality, science, truth, method, propositions, among others by means of which a new view of epistemology emerges. As for Kuhn, paradigm is his most known notion and his biggest contribution to innovate the history of science. I contrast these two conceptions and conclude that they have different uses, and that some difficulties that emerge from Kuhn＇s concept of paradigm would be dissolved if we take into consideration Witt^enstein＇s aooroaches of language and the uses it has in our life forms.
基金funded by China-Australia Joint Science and Technology Commission (2010DFA31260)China-Canada Joint Health Research Initiative (81010064)
文摘When our knowledge of a field accumulates to a certain level,we are bound to see the rise of one or more great scientists.They will make a series of grand discoveries/breakthroughs and push the discipline into an 'age of grand discoveries'.Mathematics,geography,physics and chemistry have all experienced their ages of grand discoveries;and in life sciences,the age of grand discoveries has appeared countless times since the 16th century.Thanks to the ever-changing development of molecular biology over the past 50 years,contemporary life science is once again approaching its breaking point and the trigger for this is most likely to be 'lifeomics'.At the end of the 20th century,genomics wrote out the 'script of life';proteomics decoded the script;and RNAomics,glycomics and metabolomics came into bloom.These 'omics',with their unique epistemology and methodology,quickly became the thrust of life sciences,pushing the discipline to new high.Lifeomics,which encompasses all omics,has taken shape and is now signalling the dawn of a new era,the age of grand discoveries.
基金funded by the Chinese National Basic Research Program grants(2011CB910600,2013CB911201)to Xu Ping and Li Ning respectivelythe grants of National Natural Science Foundation of China(31070673,31170780)to Xu Ping
文摘Proteomics focuses on the systematic identification and quantification of entire proteomes and interpretation of proteins’biological functions.During the last decade,proteomics in China has grown much faster than other research fields in life sciences.At the beginning of the second decade of the 21st century,the rapid development of high-resolution and high-speed mass spectrometry makes proteomics a powerful tool to study the mechanisms underlying physiological/pathological processes in organisms.This article provides a brief overview of proteomics technology development and representative scientific progress of the Human Liver Proteome Project in China over the past three years.
基金supported by the National Natural Science Foundation of China (Grant No. 51176203)the Natural Science Foundation of Naval University of Engineering (Grant No. HGDYDJJ10011)
文摘The emergence and development of constructal theory,which has been a new discipline branch to research sorts of structures in nature and engineering,are reviewed.The core of the constructal theory is that various shapes and structures of the matters in nature are generated from the tendency to obtain optimal performance.Constructal theory and its application are summarized,from disciplines such as heat,mechanism,fluid flow,electricity,magnetism and chemistry,to life and non-life systems in nature.
基金supported by the National Natural Science Foundation of China (21725402)the Science and Technology Commission of Shanghai Municipality (17XD1401600)+1 种基金Guangdong Innovative and Entrepreneurial Research Team Program (2016ZT06C322)supports from the Flow Cytometry Core Facility and the Confocal Microscopy Facility at ECNU
文摘Interests in intracellular peptide delivery have continued to grow,significantly fueled by the importance of peptides and their mimetics in modern cell biology and pharmaceutical industry.However,efficient intracellular delivery of membrane-impermeable peptides of different polarities remains a challenging task.In this study,we develop a general and robust strategy for intracellular peptide delivery by using a boronic acid-rich dendrimer.The designed material is capable of transporting peptides with different polarities and charge properties into the cytosol of various cell lines without inducing additional cytotoxicity.The transduction efficacy and proteolytic stability of cargo peptides delivered by the boronic acid-rich dendrimer are much superior to peptides conjugated with cell penetrant peptides such as octaarginine.In addition,the bioactivities of pro-apoptotic peptides are maintained after intracellular delivery.This study provides a versatile and robust platform for the intracellular delivery of membrane-impermeable peptides.
