Cancer emerged in human history for centuries. It seems that while human beings are evolving, tumors are always on their heels. In order to explain and study the mechanism of tumor progression, we proposed a new hypot...Cancer emerged in human history for centuries. It seems that while human beings are evolving, tumors are always on their heels. In order to explain and study the mechanism of tumor progression, we proposed a new hypothesis that the tumor is a retrogression of life evolution, in other word, a resurgence of some past fragments in human development history. Our inference was based on the fact that tumors are not foreign diseases, but use of human inherent developmental genes to achieve self-improvement. Characteristics and biological behavior of tumor cells are similar to human normal stem cell to some degree. Thus, studying the process of human evolution could speculate and analyze the occurrence and development of tumors. The latest research showed that many cancer treatment were also taking advantages of those features about retrogression. Continuous in-depth analysis about tumor environmental characteristics and internal law of human evolution may produce new approaches to promote cancer prevention and treatment. Our hypothesis, for the first time, proposed that taking advantage of the evolution laws to reverse the tumor progression as a path of life retrogression is better than exterminating them completely as outside enemies. Some new studies on tumor induced differentiation had also demonstrated the clinical significance of our hypothesis展开更多
To accurately evaluate the degradation process of prestressed concrete continuous bridges exposed to aggressive environments in life-cycle,a finite element-based approach with respect to the lifetime performance asses...To accurately evaluate the degradation process of prestressed concrete continuous bridges exposed to aggressive environments in life-cycle,a finite element-based approach with respect to the lifetime performance assessment of concrete bridges was proposed.The existing assessment methods were firstly introduced and compared.Some essential mechanics problems involved in the degradation process,such as the deterioration of materials properties,the reduction of sectional areas and the variation of overall structural performance caused by the first two problems,were investigated and solved.A computer program named CBDAS(Concrete Bridge Durability Analysis System) was written to perform the above-metioned approach.Finally,the degradation process of a prestressed concrete continuous bridge under chloride penetration was discussed.The results show that the concrete normal stress for serviceability limit state exceeds the threshold value after 60 a,but the various performance indicators at ultimate limit state are consistently in the allowable level during service life.Therefore,in the case of prestressed concrete bridges,the serviceability limit state is more possible to have durability problems in life-cycle;however,the performance indicators at ultimate limit state can satisfy the requirements.展开更多
LiB (lithium-ion battery) has become serious concern for energy management systems, especially in Japan, where the argument on a nuclear power plant problem is active. Including reuse of LiB, long-term use is expect...LiB (lithium-ion battery) has become serious concern for energy management systems, especially in Japan, where the argument on a nuclear power plant problem is active. Including reuse of LiB, long-term use is expected, however, method to ensure LiB life has not been developed thus the users of LiB are forced to accept the uncertainty of LiB life. Therefore this study suggests an evaluation method for LiB life using degradation experimental data. This method has three elements, defining indexes, preparing degradation speed database from the result of experiment, and setting up the use patterns of LiB. In order to be usable under non-experimental conditions, degradation speed database has the data in all conditions by complementing the experimental result. Finally, this evaluation model was verified by comparing model estimates and the experimental measurements.展开更多
This paper deals with the simple additive degradation models with single random effect. The authors further study the link between the aging property of the implied lifetime and that of the random variation. It is fou...This paper deals with the simple additive degradation models with single random effect. The authors further study the link between the aging property of the implied lifetime and that of the random variation. It is found that both the aging property of the random variation and the analytical behavior of the mean degradation path influence the aging behavior of the implied lifetime.展开更多
文摘Cancer emerged in human history for centuries. It seems that while human beings are evolving, tumors are always on their heels. In order to explain and study the mechanism of tumor progression, we proposed a new hypothesis that the tumor is a retrogression of life evolution, in other word, a resurgence of some past fragments in human development history. Our inference was based on the fact that tumors are not foreign diseases, but use of human inherent developmental genes to achieve self-improvement. Characteristics and biological behavior of tumor cells are similar to human normal stem cell to some degree. Thus, studying the process of human evolution could speculate and analyze the occurrence and development of tumors. The latest research showed that many cancer treatment were also taking advantages of those features about retrogression. Continuous in-depth analysis about tumor environmental characteristics and internal law of human evolution may produce new approaches to promote cancer prevention and treatment. Our hypothesis, for the first time, proposed that taking advantage of the evolution laws to reverse the tumor progression as a path of life retrogression is better than exterminating them completely as outside enemies. Some new studies on tumor induced differentiation had also demonstrated the clinical significance of our hypothesis
基金Project(2006.318.223.02-01) supported by the Ministry of Transportation and Communications through the Scientific and Technological Funds of ChinaProject(2007AA11Z104) supported by the High Technology Research and Development of ChinaProject(20090072110045) supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China
文摘To accurately evaluate the degradation process of prestressed concrete continuous bridges exposed to aggressive environments in life-cycle,a finite element-based approach with respect to the lifetime performance assessment of concrete bridges was proposed.The existing assessment methods were firstly introduced and compared.Some essential mechanics problems involved in the degradation process,such as the deterioration of materials properties,the reduction of sectional areas and the variation of overall structural performance caused by the first two problems,were investigated and solved.A computer program named CBDAS(Concrete Bridge Durability Analysis System) was written to perform the above-metioned approach.Finally,the degradation process of a prestressed concrete continuous bridge under chloride penetration was discussed.The results show that the concrete normal stress for serviceability limit state exceeds the threshold value after 60 a,but the various performance indicators at ultimate limit state are consistently in the allowable level during service life.Therefore,in the case of prestressed concrete bridges,the serviceability limit state is more possible to have durability problems in life-cycle;however,the performance indicators at ultimate limit state can satisfy the requirements.
文摘LiB (lithium-ion battery) has become serious concern for energy management systems, especially in Japan, where the argument on a nuclear power plant problem is active. Including reuse of LiB, long-term use is expected, however, method to ensure LiB life has not been developed thus the users of LiB are forced to accept the uncertainty of LiB life. Therefore this study suggests an evaluation method for LiB life using degradation experimental data. This method has three elements, defining indexes, preparing degradation speed database from the result of experiment, and setting up the use patterns of LiB. In order to be usable under non-experimental conditions, degradation speed database has the data in all conditions by complementing the experimental result. Finally, this evaluation model was verified by comparing model estimates and the experimental measurements.
基金supported by National Natural Science Foundation of China under Grant No.10771090
文摘This paper deals with the simple additive degradation models with single random effect. The authors further study the link between the aging property of the implied lifetime and that of the random variation. It is found that both the aging property of the random variation and the analytical behavior of the mean degradation path influence the aging behavior of the implied lifetime.