晚期浆液性卵巢癌环氧合酶2的表达与肿瘤细胞增殖、凋亡、血管生成及生存率的关系

Objective: Cyclo-oxygenase-2 seems to be involved at various steps in the processes of tumor progression. The abstract Objective of this study was to examine the relationship between cyclo- oxygenase- 2 expression and tumor proliferation, apoptosis and angiogenesis in patients with advanced stage high- grade ovarian carcinoma. Study design: Specimens from 118 patients with high- grade and advanced stage (III, IV) serous ovarian carcinoma were evaluated by immunohistochemistry for cyclo- oxygenase- 2, Ki- 67, vascular endothelial growth factor, and bcl- 2 expression. Tumor microvessel density was assessed with CD34 immunostaining. We investigated the relationships between cyclo- oxygenase- 2 expression and clinicopathologic characteristics, tumor angiogenesis (tumor microvessel density and vascular endothelial growth factor expression), and tumor proliferation and apoptosis. The effect of cyclo- oxygenase- 2 expression on patient survival was determined. Results: There was a significant positive correlation between cyclo- oxygenase- 2 expression in tumor cells and markers of tumor proliferation and angiogenesis. In univariate survival analysis, high cyclo- oxygenase- 2 and high Ki- 67 expression showed a significant impact of on patient survival (P <. 001). In multivariate regression analysis, only Ki- 67 expression retained its significance as an independent poor prognostic factor (death hazard ratio, 2.0; 95% CI, 1.2- 3.3;P <. 001). Conclusion: Expression of cyclo- oxygenase- 2 correlates with tumor proliferation and tumor angiogenesis but not with apoptotic markers (bcl- 2 expression) in high- grade, advanced- stage serous ovarian carcinoma. Catastrophizing labor pain compromises later maternity adjustments Ferber S.G./Granot M./Zimmer E.Z. [Dr. S.G. Ferber, Fac. Social Welf. and Hlth. Studs., University of Haifa, Mount Carmel, Haifa 31905, Israel] Abstract Objective: The purpose of this study was to evaluate the impact of labor pain intensity and labor pain catastrophizing on maternity blues and postpartum social functioning. Study design: Pain intensity and pain catastrophizing were assessed in 89 women in active labor before the administration of analgesia. Both these measures were assessed again retrospectively 2 days after delivery in 82 women who had a spontaneous vaginal delivery. Women also filled out the Edinburgh Postnatal Depression Scale. Six weeks later women completed the social functioning domain of the short form SF36 health survey. Results: Pain catastrophizing during labor significantly predicted both maternity blues (P =. 001) and postpartum social functioning (P =. 001) when being controlled for maternal age and education, parity, type of analgesia, and labor pain intensity. Low level of education and younger age also contributed to the prediction of maternity blues and social functioning. Conclusion: Labor pain catastrophizing rather than labor pain intensity predicts postpartum maternal adjustments.

储蓄实名制的五大好处

与存款记名制相比,实行存款实名制的益处,主要表现在以下几方面: 第一,有利于保障存款人的利益。在存款记名制条件下,由于笔名、假名、化名及其他代码不具有对应的身份证件,所以,一旦发生存单遗失。

Prognostic factors for the survival of 66 cases with extensive stage-small cell lung cancer

Objective The objective of this retrospective study was to investigate the prognostic factors associated with survival among patients with extensive stage-smal cel lung cancer （ES-SCLC）. Methods Clinical data from 66 patients with ES-SCLC diagnosed via histopathology or cytology between July 2005 and July 2009 at Anyang Tumor Hospital （China） were analyzed. Univariate and multivariate Kaplan-Meier, log-rank, and Cox proportional hazard regression analyses were conducted. Results The 12-, 24-, and 36-month survival rates among patients with ES-SCLC were 40.9%, 13.6%, and 6.1%, respectively. The median survival time （MST） was 10 months. Univariate analyses indicated that weight loss, eficacy of first-line chemotherapy, total number of chemotherapy cycles, treatment meth-od, and serum sodium levels significantly influenced survival among patients with ES-SCLC. Multivariate analyses suggested that the eficacy of first-line chemotherapy, total number of chemotherapy cycles, and serum sodium levels were independent prognostic factors associated with survival. Conclusion The eficacy of first-line chemotherapy, total number of chemotherapy cycles, and serum sodium levels are important prognostic factors for patients with ES-SCLC.

Comparative studies on storage cells in tardigrades during starvation and anhydrobiosis

The impact of starvation and anhydrobiosis on the number and size of the storage cells in the tardigrade species Milnesium tardigradum, Paramacrobiotus tonollii and Macrobiotus sapiens was investigated to gain more insight on the energetic side of anhydrobiosis. Storage cells are free floating cells within the body cavity of tardigrades and are presumed to store and release energy in form of glycogen, protein and fat to maintain a constant nutrient regime for the other tissues. The body size of the animals was not correlated with the size of the storage cells, however, M. tardigradum the largest species analysed also had the largest storage cells. A reduction in the size of the storage cells is apparent in all three species after seven days of starvation. A seven-day period of anhydrobiosis leads to a decrease in cell size in M. tardigradum but not in P. tonollii and M. sapiens. Although M. sapiens was raised on green algae, and M. tardigradum and P. tonollii were fed with rotifers and nematodes this difference in nourishment was not reflected in the response of the storage cells to anhydrobiosis

改刊寄语

鸡年大吉,我院全体师生同全国人民一道迎来了令人振奋的1993年！过去的一年里,全国人民在邓小平南巡讲话与党的「十四大」精神鼓舞下,开创了令世人瞩目的可喜局面。我院广大师生在院领导的筹划下,成功地举办了首次赴京汇报展,将我院多年来的整体学术风貌与艺术成就推向全国美术界,获得了广泛的关注与声誉。

STAT3和胃癌的研究进展

人类STAT3基因定位于第17号染色体(q21.31),STAT3蛋白是信号转导子与转录激活子家族(signal transducers and activators of transcription,STATs)的重要成员。近年来,STAT3与胃癌(gastric cancer,GC)关系引起人们的广泛关注,现就其研究进展作一综述。一、STAT3概述1.STAT3的结构与功能:STAT3蛋白包括七个部分:SH2区、SH3区、羧基端第705位的酪氨酸磷酸化位点(Y705)、DNA结合区、保守性较差的羧基端、第727位的丝氨酸磷酸化位点(S727)和保守的氨基酸序列[1]。一旦STAT3被磷酸化和激活,

Survival analysis of a stochastic single-species population model with jumps in a polluted environment

This paper is concerned with a stochastic single-species system with Levy jumps in a polluted environment. Some sufficient conditions on extinction, non-persistence in the mean, weak persistence in the mean, strong persistence in the mean, stability in the mean and stochastic permanence are obtained. The threshold between extinction and weak persistence in the mean is established. At the same time, under a simple condition, it is proved that this threshold also is the threshold between extinction and stability in the mean. The results reveal that L@vy jumps have significant effects to the persistence and extinction results.