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多样本生存率检验 被引量:5
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作者 赵国龙 杜诗军 《中国卫生统计》 CSCD 北大核心 1994年第6期11-13,共3页
本文将经典多样本率检验加以扩展,使之适应终检以用于多样本生存率比较。扩展机制是以KaPlan-Meier或Berkson-Gage估计值取代经验分布函数的补,以同源性有效样本容量取代样本容量.无终检时,它还原为经典方... 本文将经典多样本率检验加以扩展,使之适应终检以用于多样本生存率比较。扩展机制是以KaPlan-Meier或Berkson-Gage估计值取代经验分布函数的补,以同源性有效样本容量取代样本容量.无终检时,它还原为经典方法。模拟试验表明,该方法对于指数生存分布是精确的,对于形状参数为1/3-3的Weibull分布仍可适用。 展开更多
关键词 终检 卡方检验 生存统计
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Relationship between platelet count and gastric cancer stage and prognosis 被引量:1
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作者 Xinting Lv Yingjie Li Tao Chen Ning Li 《The Chinese-German Journal of Clinical Oncology》 CAS 2010年第4期213-215,共3页
Objective:The aim of the research was to investigate the relationship between gastric cancer stage, prognosis and blood platelets count. Methods: Platelet (PLT) count was analyzed retrospectively in 203 patients with ... Objective:The aim of the research was to investigate the relationship between gastric cancer stage, prognosis and blood platelets count. Methods: Platelet (PLT) count was analyzed retrospectively in 203 patients with gastric cancer from 1998 to 2002. The survivals of gastric cancer were compared between normal PLT group and thrombocytosis group. Results: Among 203 cases, PLT increased in 21 cases. The average platelet counts of patients at different stages had statistically significant differences (P<0.01). The 3-and 5-year survivals in patients of thrombocytosis group were lower than those of the normal PLT group (P<0.01). Conclusion: Thrombocytosis in gastric cancers with advanced stage are common. And PLT count can be a prognostic indicator of survival in patients with gastric cancer undergoing gastrectomy. 展开更多
关键词 stomach neoplasms platelet (PLT) count THROMBOCYTOSIS PROGNOSIS
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Clinicopathological analysis of paraganglioma with literature review 被引量:6
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作者 Ning Feng Wen-Yan Zhang Xiao-Ting Wu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第24期3003-3008,共6页
AIM: To investigate the 152 cases of paragangliomas resected over the past 32 years in West China Hospital dinicopathologically.METHODS: All cases of paragangliomas diagnosed at the Department of Gastrointestinal Su... AIM: To investigate the 152 cases of paragangliomas resected over the past 32 years in West China Hospital dinicopathologically.METHODS: All cases of paragangliomas diagnosed at the Department of Gastrointestinal Surgery and Department of Pathology, West China Hospital, China were reviewed. The pathological documents were supplied by the Department of Pathology, West China Hospital, and other necessary data were extracted from the hospital records. The statistical analyses were performed by survival analysis (Kaplan-Meier method), descriptive statistical analyses and Х^2 analysis.RESULTS: The neuroendocrine marker vimentin was found to be selectively expressed in the benign tumors, and there were significant differences in the expression of those markers in both benign and malignant tumors. The survival analysis revealed that survival correlated significantly with the malignancy, metastasis and nodal status.CONCLUSION: Vimentin may be useful in the differential diagnosis between malignant and benign tumors. The difference in the expression of this marker in the tumors could be a clue to the future clinical diagnosis. The malignancy, metastasis and the nodal status may predict the prognosis of this disease. 展开更多
关键词 PARAGANGLIOMA Retroperitoneal tumor CARCINOMA Neuroendocrine tumors Neuroendocrine peptide VIMENTIN Survival analysis
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Modeling and analysis of cloud computing system survivability based on Bio-PEPA 被引量:1
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作者 Zhao Guosheng Ren Mengqi +1 位作者 Wang Jian Liao Yiwei 《Journal of Southeast University(English Edition)》 EI CAS 2018年第1期21-27,共7页
For the cloud computing system,combined wth the memory function and incomplete matching of the biological immune system,a formal modeling and analysis method of the cloud computing system survivability is proposed by ... For the cloud computing system,combined wth the memory function and incomplete matching of the biological immune system,a formal modeling and analysis method of the cloud computing system survivability is proposed by analyzing the survival situation of critical cloud services.First,on the basis of the SAIR(susceptible,active,infected,recovered)model,the SEIRS(susceptible,exposed,infected,recovered,susceptible)model and the vulnerability diffusion model of the distributed virtual system,the evolution state of the virus is divided into six types,and then the diffusion rules of the virus in the service domain of the cloud computing system and the propagation rules between service domains are analyzee.Finally,on the basis of Bio-PEPA(biological-performance evaluation process algebra),the formalized modeling of the survivability evolution of critical cloud services is made,and the SLIRAS(susceptible,latent,infected,recovered,antidotal,susceptible)model is obtained.Based on the stochastic simulation and the ODEs(ordinary differential equations)simulation of the Bio-PEPA model,the sensitivity parameters of the model are analyzed from three aspects,namely,the virus propagation speed of inter-domain,recovery ability and memory ability.The results showthat the proposed model has high approximate fitting degree to the actual cloud computing system,and it can well reflect the survivable change of the system. 展开更多
关键词 cloud computing system Bio-I>EPA(biologicalperformance evaluation process algebra) SURVIVABILITY stochastic simulation
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使用EpiInfo软件进行生存分析方法简介
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作者 陶庄 《海峡预防医学杂志》 CAS 2009年第5期80-82,共3页
[目的]介绍使用EpiInfo软件进行生存分析的方法。[方法]用一个监测戒毒效果的例子,说明使用EpiIn-fo软件进行生存分析的步骤并给予解释。[结果]在EpiInfo软件进行简单的设置后,软件给出了简明可靠的结果。[结论]生存分析是对监测数据进... [目的]介绍使用EpiInfo软件进行生存分析的方法。[方法]用一个监测戒毒效果的例子,说明使用EpiIn-fo软件进行生存分析的步骤并给予解释。[结果]在EpiInfo软件进行简单的设置后,软件给出了简明可靠的结果。[结论]生存分析是对监测数据进行分析的重要方法,而EpiInfo软件是便捷、功能全面、可靠且免费的工具。 展开更多
关键词 生存统计 Kaplan—Meier估计 Cox比例危险模型 EpiInfo软件包
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氟尿嘧啶血药浓度监测在进一步提高晚期胃癌化疗疗效及减少不良反应预测中的作用 被引量:22
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作者 蔡讯 薛鹏 +4 位作者 宋卫峰 胡炯 顾鸿莉 杨海燕 王理伟 《肿瘤》 CAS CSCD 北大核心 2011年第10期930-936,共7页
目的:回顾性分析70例局部进展或转移性胃癌患者化疗后氟尿嘧啶(fluorouracil,5-FU)血药浓度与疗效及不良反应之间的关系,明确其在进一步提高疗效及减少不良反应中的作用。方法:70例不可切除局部进展或转移性胃癌患者随机接受多西他赛+顺... 目的:回顾性分析70例局部进展或转移性胃癌患者化疗后氟尿嘧啶(fluorouracil,5-FU)血药浓度与疗效及不良反应之间的关系,明确其在进一步提高疗效及减少不良反应中的作用。方法:70例不可切除局部进展或转移性胃癌患者随机接受多西他赛+顺铂+氟尿嘧啶(docetaxol+cisplatin+fluorouracil,DCF)或多西他赛+奥沙利铂+氟尿嘧啶(docetaxol+oxaliplatin+fluorouracil,DOF)3周方案化疗至少4个周期,于每周期5-FU持续滴注开始后12h应用高效液相色谱法检测5-FU血药浓度(检测时间控制在4~6AM)。分别取各周期血药浓度的平均值,通过逐步回归分析筛选与5-FU血药浓度相关的因素。再根据5-FU血药浓度有效预测可信区间分为≤25.5mg/L、25.6~37.4mg/L及>37.4mg/L3组,回顾性分析不同5-FU血药浓度与化疗疗效及不良反应之间的关系。结果:逐步回归分析提示,5-FU血药浓度与骨髓抑制、黏膜炎、无进展生存(progression-freesurvival,PFS)及总生存(overallsurvival,OS)相关,3组5-FU平均血药浓度分别为(20.73±3.80)mg/L、(31.98±3.10)mg/L和(40.32±3.45)mg/L(χ2=66.24,P<0.001),中位PFS分别为(4.50±0.19)(、6.00±0.32)和(7.50±0.75)个月(χ2=22.09,P<0.001),中位OS分别为(8.50±1.00)、(13.00±1.58)和(12.50±2.66)个月(χ2=32.32,P<0.001),第2、3组均明显高于第1组,第3组骨髓抑制和黏膜炎的发生率高于前两组(P=0.04和P=0.03)。结论:晚期胃癌患者在5-FU为基础的方案化疗后,5-FU血药浓度维持在25.6~37.4mg/L者能获得更好的生存,患者耐受性较好,骨髓抑制(尤其是Ⅲ/Ⅳ度)和黏膜炎等不良反应发生率亦较低。 展开更多
关键词 胃肿瘤 血药浓度 氟尿嘧啶 药物监测 化疗反应 Kaplan—Meiers生存统计
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中国现代数学家寿命分析 被引量:1
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作者 李仲来 《数学的实践与认识》 CSCD 北大核心 2005年第3期99-104,共6页
根据 2 1 2位中国现代数学家 (1 1 7位逝世 )的生存资料进行分析 ,得到如下结果 . 62位院士的期望寿命为 84.68岁 ,标准误差为 1 .96岁 ;1 5 0位非院士数学家的期望寿命为 79.2 6岁 ,标准误差为 1 .1 3岁 .院士和非院士数学家的寿命差... 根据 2 1 2位中国现代数学家 (1 1 7位逝世 )的生存资料进行分析 ,得到如下结果 . 62位院士的期望寿命为 84.68岁 ,标准误差为 1 .96岁 ;1 5 0位非院士数学家的期望寿命为 79.2 6岁 ,标准误差为 1 .1 3岁 .院士和非院士数学家的寿命差异有显著性意义 (P =0 .0 5 ) .分别给出了院士和非院士数学家两个群体的寿命表 .结论 :中国现代数学家属于长寿之列 .脑部疾病、心脏疾病和癌症为数学家的主要死因 . 展开更多
关键词 中国 现代数学家 寿命 生存资料统计 死因 平均期望
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Human Response to Degradation of Ecosystems 被引量:1
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作者 Krittika Roy 《Journal of Resources and Ecology》 CSCD 2016年第4期261-268,共8页
Our ecosystem provides us with essential services, most of which come without a price tag and hence are assumed to be "free gifts of nature" available in plenty. Much of the neoclassical thought and analysis was bas... Our ecosystem provides us with essential services, most of which come without a price tag and hence are assumed to be "free gifts of nature" available in plenty. Much of the neoclassical thought and analysis was based on this assumption until recently. The dynamic rise in population due to rapid industrialisation and urbanization has caused the realisation that ecosystem services are also limited. Environmental degradation is a common term used to describe the loss or impairment of ecosystem services. Migration is often a consequence of environ- mental degradation; when ecosystem services are impaired and survival comes at stake. But is the degradation of essential ecosystem services sufficient to motivate people to relocate? Through a review of literature on migration and environmental degradation, this paper strives to answer the above question along with exploring ways how monitoring the deterioration of the environment on time can spare human inhabitants of any ecosystem the pains of migration in search of better means of survival and sustenance. 展开更多
关键词 MIGRATION environmental degradation ecosystem services survival sustenance
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矾矿工人矽肺的转归分析
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作者 闻永轩 吴中亚 丁效惠 《职业医学》 1989年第3期16-18,64,共3页
本文阐述了矽-矾共存矿山矽肺患者的转归情况,用寿命表法生存率统计对101例单纯Ⅰ期矽肺患者进行病情稳定和尚存情况分析。累积晋期率概率单位与诊断后年数呈正相关,病情稳定在50%的期望年限为诊断后第12.33年,累积生存率概率单位与诊... 本文阐述了矽-矾共存矿山矽肺患者的转归情况,用寿命表法生存率统计对101例单纯Ⅰ期矽肺患者进行病情稳定和尚存情况分析。累积晋期率概率单位与诊断后年数呈正相关,病情稳定在50%的期望年限为诊断后第12.33年,累积生存率概率单位与诊断后年数呈负相关,生存率在50%的期望年限为诊断后第15年。认为矽-矾共存的矿山矽肺患者预后较差,应做好三级预防。 展开更多
关键词 矽肺 矽-矾矿 矽肺转归分析 生存统计 职业病
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