第6届图像和信号处理,生物医学工程和信息国际会议（英文）

The 2013 6th International Congress on Image and Signal Processing(CISP 2013)and the 2013 6th International Conference on BioMedical Engineering and Informatics(BMEI 2013)will be jointly held in Hangzhou,China.CISP-BMEI2013 is a premier international forum for scientists and researchers to present the state-of-the-art of multimedia,signal processing,biomedical engineering and informatics and to discuss future research challenges.Co-locating two conferences we aim to promote collaboration among multiple areas,especially the interactions of engineering,computing,and medicine.CISP’13-BMEI'13 is technically co-sponsored by the IEEE Engineering in Medicine and Biology Society.

Doctor-patient communication starts from medical students

Currently,with the increasing tensionin doctor-patient relationship and medical disputes,it is of great practical importance to train medical students’communication skills in order to establisha harmonious doctor-patient relationship to improve the quality of clinical teaching.This paper emphasizes the importance of cultivation of communication skills in medical education and suggests ways to improve communication skills among medical students.

Serum-free culture of H pylori intensifies cytotoxicity

AIM： To perform a long culture passage of H pylori without serum, taking into account its cytotoxicity and the presence of the probable new cytotoxic factor. METHODS： One sample of H pylon 60190 （ATCC 49503） was grown on Brain Heart Infusion （BHI） agar containing 0.5% 2,6-di-O-methyl-β-cyclodextrin without any serum, being passaged 70-100 times every 3-4 d for approximately 2 h, while another sample of H pylori contained 70 mL/L fetal calf serum without 2,6-di-O- methyl-β-cyclodextrin. Their supernatant and extract after 16 h in culture were evaluated for changes in cell morphology and for cell viability using HeLa cells. Furthermore, the characteristics of the probable cytotoxic factor in the extract were examined on partial purification studies and its oytotoxicity was evaluated in various human cells. RESULTS： The supernatant and the extract of the bacterium grown on serum-free medium had strong cytotoxicity compared with those grown on serumcontaining medium. They irreversibly damaged HeLa cells without vacuolation that was altogether different from that of the bacterium when grown with serum. Their cytotoxicity was easily measured by cell viability assay. The probable cytotoxic factor partially purified and detected by chromatography had characteristics difference from that of vacuolating toxin and a broad cytotoxicity toward various cell lines. CONCLUSION： Serum-free long culture method of H pylorl makes its supernatant and its extract cytotoxic enough to be easily measured by cell viability assay. The probable cytotoxic factor has a unique characteristic and might be a new cytotoxin.

Quantum Dots for Cancer Research:Current Status,Remaining Issues,and Future Perspectives

Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide.The mechanisms of carcinogenesis,cancer invasion,and metastasis remain unclear.Thus,the development of a novel approach for cancer detection is urgent,and real-time monitoring is crucial in revealing its underlying biological mechanisms.With the optical and chemical advantages of quantum dots(QDs),QD-based nanotechnology is helpful in constructing a biomedical imaging platform for cancer behavior study.This review mainly focuses on the application of QD-based nanotechnology in cancer cell imaging and tumor microenvironment studies both in vivo and in vitro,as well as the remaining issues and future perspectives.

Synthesis and characterization of Ti-Co alloy foam for biomedical applications

Highly porous Ti-Co alloy specimens for biomedical applications were synthesized by powder metallurgy based space holder technique. Ti alloys have high melting temperature and affinity for oxygen, which makes Ti alloys difficult to be processed. The Co addition reduces the melting temperature and Ti-Co alloy was sintered at lower temperatures. The electrochemical corrosion behaviour of the specimens was examined in the artificial saliva solution. The effects of Co content of the alloy, the p H value and fluoride concentration of the artificial saliva solution on the electrochemical corrosion properties of the specimens were investigated. The microstructure and mechanical properties of the specimens were examined. The electrochemical impedance spectroscopy results indicate that the corrosion resistance of the specimens decreases at high fluoride concentrations and low p H value. The defect density increases with increasing the fluoride concentration and decreasing the p H value of artificial saliva according to Mott-Schottky analysis.

The Latest Progress in Varying-coefficient Models

Varying-coefficient models are a useful extension of classical linear model. They are widely applied to economics, biomedicine, epidemiology, and so on. There are extensive studies on them in the latest three decade years. In this paper, many of models related to varying-coefficient models are gathered up. All kinds of the estimation procedures and theory of hypothesis test on the varying-coefficients model are summarized. Prom my opinion, some aspects waiting to study are proposed.

Regenerative medicine technology applied to gastroenterology:Current status and future perspectives

This special issue of World Journal of Gastroenterology has been conceived to illustrate to gastroenterology operators the role that regenerative medicine(RM) will have in the progress of gastrointestinal(GI) medicine.RM is a multidisciplinary field aiming to replace,regenerate or repair diseased tissues or organs.The past decade has been marked by numerous ground-breaking achievements that led experts in the field to manufacture functional substitutes of relatively simple organs.This progress is paving the ground for investigations that aims to the bioengineering and regeneration of more complex organs like livers,pancreas and intestine.In this special issue,the reader will be introduced,hand-in-hand,to explore the field of RM and will be educated on the progress,pitfalls and promise of RM technologies as applied to GI medicine.

Doctors' faith

We make some efforts to find some connections between religion and medical science. Medical science can be regarded as sacred and holy as a religion for doctors to believe. The common points between them are the basis to successfully integrate them into doctors' faith. Furthermore, we explain that doctors need a faith to believe so as to meet the demand of humanitarian traits we should have and to do better in the scientific work and win in the battles with the diseases.

Facing pressure: How should medical students or future doctors do?

On April 1st 2013, HUNG Yang, a medical master student in Fudan University, was poisoned by his roommate, LIN Senhao Unfortunately, HUANG died 15 days later. It＇s quite a shock to the whole society. We have to reconsider our education, and our expectancy to doctors. We have to ask ourselves ＂How to become a qualified doctor？＂Leam to release the pressure from studies and lives; learn to defend ourselves from danger. Is it enough？ No~ Whatever happened, never do harm to others. Medical humanity is the most important thing we should always remember

How to lead foreign students into Traditional Chinese Medicine

Traditional Chinese Medicine (TCM) is becoming much more international and widely accepted. More and more foreign students come to China's Mainland to study this great yet mysterious discipline. However, the current teaching methods are far from satisfaction. This paper analyzes some existing problems and contradictions present in the teaching practices and suggests some measures for improvement.

Strategic Scientific and Technological Capacity-Building in Clinical Medicine in China:Taking the Innovative Development of Reproductive Medicine at Peking University Third Hospital as an Example

Based on the macroanalysis of the unbalanced development of the"demand side"and the"supply side"of clinical medicine in China,this paper elucidates the stakeholders,resources,and ecosystem of the strategic scientific and technological capacity-building and calls for a larger coverage,smoother supply chain,and more sustainable ecosystem to ensure the development of clinical medicine.Furthermore,focusing on the establishment and development of clinical reproductive health in China,the authors introduce the strategic scientific and technological capacity-building of reproductive medicine in Peking University Third Hospital,with an attempt to inform similar efforts in other fields and even the whole clinical medicine in China.

Nursing undergraduates’experiences of a simulation-centred educational program in hospice care in Macao:A qualitative research

Objectives:The study aimed to explore the experiences of nursing undergraduates participating in a simulation-centred educational program in hospice care in Macao,China.Methods:This descriptive qualitative study was based on the data collected through semi-structured individual interviews.Seventeen nursing undergraduates in Macao,China who attended the simulation-centred program in hospice care participated in this qualitative from November to December 2020.This program included three parts:introduction to hospice care(2 h),management of terminal symptoms(10 h),and hospice situation simulations(6 h).The interview data were analyzed using qualitative content analysis.Results:This study revealed two themes and six sub-themes.Theme 1 was developing competencies in caring for dying patients and their families,which included four subcategories of sensitivity to patients’needs,knowledge of hospice care,skills of symptom control and comfort supply,and communication skills.Theme 2 was improving the ability to self-care and support colleagues,which included two subcategories of reflection on life and death and sharing and supporting among colleagues.Conclusion:This program improved the competency of nursing undergraduates in hospice care and participants’learning experience was good.

Effect of thermo-mechanical processing on microstructure and electrochemical behavior of Ti-Nb-Zr-V new metastable β titanium biomedical alloy

The influence of thermo-mechanical processing (TMP) on the microstructure and the electrochemical behavior of new metastableβ alloy Ti?20.6Nb?13.6Zr?0.5V (TNZV) was investigated. The TMP included hot working in belowβ transus, solution heat treatments at the same temperature and different cooling rates in addition to aging. Depending upon the TMP conditions, a wide range of microstructures with varying spatial distributions and morphologies of equiaxed/elongatedα andβ phases were attained, allowing for a wide range of electrochemical properties to be achieved. The corrosion behavior of the studied alloy was evaluated in a Ringer’s solution at 37 °C via open circuit potential?time and potentiodynamic polarization measurements.

In Vitro Study of Influence of Mimic Cardiac Rate on Hydrodynamics of the Different Mechanical Cardiac Valve Prostheses

Objective:To assess the influe nce of mimic cardiac rate on hydrodynamics of the different mechanical prostheti c cardiac valves.Methods:US-made CarboMedics bile aflet valve and China-made Jiuling bileafle t valve and C-L tilting disc valve have been tested in a pulsatile flow simulat or in the aortic position. The testing condition was set at the mimic cardiac r ate of 55 beats/min,75 beats/min,100beats/min and a constant mimic cardiac out put of 4L/min. The mean pressure differences(ΔP),leakage volumes (LEV) and closi ng volumes(CLV) across each valve,and the effective orifice areas(EOA) have bee n analyzed.Results:Within the range of physiology, the ΔP,LEV and CLV were falling as the increasing of mimic cardiac rate,and the extent of variance was larger. The EOA was increasing with the increase of the mimic cardiac rate. It is a differe nt response as the altering of the cardiac rate for the different type of the me chanical prosthetic cardiac valves.Conclusions:The change of the mimic cardiac rate can affect the hydrodynamics of the mechanical prosthetic cardiac valves. The hydrodynamics of the bileaflet valve prosthesis is better than the tilting disc valve.

A hybrid method for extraction of protein-protein interactions from literature

In this work, a hybrid method is proposed to eliminate the limitations of traditional protein-protein interactions （PPIs） extraction methods, such as pattern learning and machine learning. Each sentence from the biomedical literature containing a protein pair describes a PPI which is predicted by first learning syntax patterns typical of PPIs from training corpus and then using their presence as features, along with bag-of-word features in a maximum entropy model. Tested on the BioCreAtIve corpus, the PPIs extraction method, which achieved a precision rate of 64%, recall rate of 60%, improved the performance in terms of F1 value by 11% compared with the component pure pattern- based and bag-of-word methods. The results on this test set were also compared with other three extraction methods and found to improve the performance remarkably.

The ＂Metaphysical Physician＂ in Victorian Fiction： The Moonstone and A Romance of Two Worlds

The Victorian period experienced, among many other paradoxes, an ongoing tension between science and spirituality. Bearing the legacy of the ＂Enlightenment Rationalism＂ and the Cartesian division between ＂matter＂ and ＂mind＂ since the eighteenth century, the Victorian minds had to deal with a contemporary world rapidly unfolding new discoveries in geology, astronomy, biology, and medical sciences. However, these could not completely erase the spiritual belief from the human mind. Rather they sought to reshape their codes in terms of ＂alternative sciences＂ like occultism and metaphysical psychiatry （pre-Freudian）. This paper seeks to explore the characterisation of the ＂metaphysical＂ physician in two novels by Wilkie Collins and Marie Corelli, showing how these figures play a crucial role in negotiating the tensions between science and spiritualism.

Multiphoton microscopy:An introduction to gastroenterologists

Multiphoton microscopy, relying on the simultaneous absorption of two or more photons by a fluorophore, has come to occupy a prominent place in modern biomedical research with its ability to allow real-time observation of a single cell and molecules in intact tissues. Multiphoton microscopy exhibits nonlinear optical contrast properties, which can make it possible to provide an exceptionally large depth penetration with less phototoxicity. This system becomes more and more an inspiring tool for a non-invasive imaging system to realize "optical biopsy" and to examine the functions of living cells. In this review, we briefly present the physical principles and properties of multiphoton microscopy as well as the current applications in biological fields. In addition, we address what we see as the future potential of multiphoton microscopy for gastroenterologic research.

About Laparoscopic Surgery Teaching Methods Discussed in this Paper

Surgery as one of the backbone of the clinical medical disciplines, it is a practical subject and the surgery teaching is an important component part of the surgery, is also a medical student to study the surgical aseptic technique and basic knowledge of the surgery and surgical basic skills, the students learned an important part of the theory is applied to clinical practice. Laparoscopy is a new technology, how to apply this new medical technology in surgery, to help students in the limited class hours quickly mastering their own knowledge, this is at present our country facing the most important subject in medical teaching. In view of the present of laparoscopic surgery in school teaching method were discussed and analyzed, and on how to have a purpose, systematic training students to master this skill, and to lay a good foundation of surgical basic skills of students, set up a bridge from slowly towards the classroom teaching of clinical practice.

Second Language Repertoires Reflecting on Teaching IsiXhosa to Medical Students

The Language Policy for Higher Education （2002） and University of Cape Town＇s Language Plan （2001） suggest that language is central to our social and academic engagement at every level： to our communication with those around us, to our learning, and to our identities. The purpose of this paper is to show how the medical school, after making progress towards implementing the University of Cape Town＇s Language Plan of 2001, is compelled to encourage isiXhosa language developers to develop the necessary and relevant vocabulary responding to the needs of the target users. In some cases, there is a need to adopt terms that are already available and being used by the speech community to align them in the curriculum. Research conducted by analyzing field notes, having plenary discussions with students, observations during clinical practice, reflecting on the curriculum and study materials material. Results indicated the significance of teaching isiXhosa drawing from the medical jargon understood amongst patients, doctors, and nurses. This paper discusses the status enjoyed by isiXhosa to date, language teaching and teaching matters pertaining to isiXhosa, and reflection on whether there is benefit in learning isiXhosa.

Recommendations on Strengthening the Development of Nuclear Medicine in China

This paper outlines briefly the role of nuclear medicine in life sciences and health care. Molecular imaging by using isotopic tracers can noninvasively visualize the chemistry or hidden process in the cells and tissues inside the body, obtaining "functional" images to provide early information of any disease and revealing the secrets of life. The vitality of nuclear medicine is its ability to translate bench into new clinical application that can benefits the patients. Although nuclear medicine community in China has made significant achievement with a great effort since 1950s, there are many obstacles to future development. Recommended measures are proposed here in an attempt to solve our existing problems.