The purpose of this paper was to investigate the possibility of treating C. I. Reactive Blue 19 wastewater by electrochemical oxidation via electrogenerated active chlorine, using metallic oxide coatings （dimensional...The purpose of this paper was to investigate the possibility of treating C. I. Reactive Blue 19 wastewater by electrochemical oxidation via electrogenerated active chlorine, using metallic oxide coatings （dimensional stable anode, DSA） as anode. The electrolysis for the simulated wastewater was conducted at a constant current. Absorbances at 592 nm and 255 nm were measured to follow the decolorization of the dye and the degradatin of its aromatic ring. After 4 h of electrolysis under the experimental conditions： current density of 15 A·m^-2, 0.2 mol·L^-1 NaCl, 0.1 mol·L^-1 Na2SO4, 0.1 mmol·L^-1 dye, initial pH=6.4 and T=30℃, 100% decolorization of the dye and about 45% degradation of its aromatic ring were achieved, while no obvious change of total organic carbon was observed. The experimental results suggest that the decolorization of the dye and degradation of its aromatic ring were directly affected by current density, temperature, concentrations of the dye and sodium chloride, while slightly affected by initial pH and sodium sulfate concentration; the decolorization of the dye and degradation of its aromatic ring followed pseudo-first-order kinetics; and indirect electrooxidation, using electrogenerated active chlorine, predominated in the electrochemical oxidation.展开更多
Many flaviviruses are significant human pathogens causing considerable disease burdens,including encephalitis and hemorrhagic fever,in the regions in which they are endemic.A paucity of treatments for flaviviral infec...Many flaviviruses are significant human pathogens causing considerable disease burdens,including encephalitis and hemorrhagic fever,in the regions in which they are endemic.A paucity of treatments for flaviviral infections has driven interest in drug development targeting proteins essential to flavivirus replication,such as the viral protease.During viral replication,the flavivirus genome is translated as a single polyprotein precursor,which must be cleaved into individual proteins by a complex of the viral protease,NS3,and its cofactor,NS2B.Because this cleavage is an obligate step of the viral life-cycle,the flavivirus protease is an attractive target for antiviral drug development.In this review,we will survey recent drug development studies targeting the NS3 active site,as well as studies targeting an NS2B/NS3interaction site determined from flavivirus protease crystal structures.展开更多
Rice straw is supposed to be an environment-friendly biomaterial for inhibiting the growth of harmful blooms of the cyanobacterium Microcystis aeruginosa. However, its potential mechanism is not well known. To explore...Rice straw is supposed to be an environment-friendly biomaterial for inhibiting the growth of harmful blooms of the cyanobacterium Microcystis aeruginosa. However, its potential mechanism is not well known. To explore this mechanism, the growth, cell viability(esterase activity, membrane potential, and membrane integrity), photosynthesis, and cell size of M. aeruginosa were determined using fl ow cytometry and Phyto-PAM after exposure to rice straw extracts(RSE). The results show that doses from 2.0 to 10.0 g/L of RSE effi ciently inhibited the alga for 15 days, while the physiologic and morphologic responses of the cyanobacteria were time-dependent. RSE interfered with the cell membrane potential, cell size, and in vivo chlorophyll- a fl uorescence on the fi rst day. After 7 days of exposure, RSE was transported into the cytosol, which disrupted enzyme activity and photosynthesis. The cyanobacteria then started to repair its physiology(enzyme activity, photosynthesis) and remained viable, suggesting that rice straw act as an algistatic agent.展开更多
A solution of 0.1 mol/L to 1.0 mol/L H2SO4 can dissolve alkali metals and alkaline earth metals which weaken an active site of SCR catalyst. The waste catalyst washed with 0.5 mol/L H2SO4 regained the best catalytic a...A solution of 0.1 mol/L to 1.0 mol/L H2SO4 can dissolve alkali metals and alkaline earth metals which weaken an active site of SCR catalyst. The waste catalyst washed with 0.5 mol/L H2SO4 regained the best catalytic activity. When a concentration of the sulfuric acid is less than 0.5 mol/L, sufficient cleaning effects cannot be obtained. In contrast, when the concentration is greater than 1.0 tool/L, the active components, vanadium and tungsten are undesirably eluted. The total BET surface of the catalyst regenerated by air lift loop reactor showed almost the same as that of fresh catalyst due to the removal of insoluble compounds which may be penetrated into pores of catalyst. The addition of a solution of 0.075 mol/L ammonium vanadate （NHnVO3） and 0.075 mol/L ammonium paratungstate （5（NH4）20· 12WO3-5H20） to 0.1 mol/L H2SO4 significantly increases the activity of the waste catalyst.展开更多
In spite the fact that Emily Elizabeth Dickinson lived during the 19th century Amherst among conservative community that gave less chance to female voice to gain a share in social and political life, she paved the way...In spite the fact that Emily Elizabeth Dickinson lived during the 19th century Amherst among conservative community that gave less chance to female voice to gain a share in social and political life, she paved the way for the coming female thinkers to obtain more freedom of thought and expression. In other words, since she was convient that ＂Abdiction of Belief makes the Behaviour Small＂, she undercut social conventions and moved under gradual shift from Orthodox Trinitarianism into new thoughts of liberalism. However, in good deal of her work, she still pertains to religious conservatism in wider sense than Amhest Church had been dectated.展开更多
Rize has a different and special flora because of its geographical position, climate, and topography. The natural plants of Rize have a very big usage potential and value in some sort of intrustrial branches. In parti...Rize has a different and special flora because of its geographical position, climate, and topography. The natural plants of Rize have a very big usage potential and value in some sort of intrustrial branches. In particular, the antimicrobial activity of natural plant oils and extracts has formed the basis of many applications, including raw and processed food preservation, pharmaceuticals, alternative medicine and natural therapies： These natural plants can be listed as follows： Artemisia absinthium L., Achi[[ea millefolium L., Astragalus schizopterus Boiss, Ajuga orientalis L., Humulus lupulus L,, Mentha longifolia L., Melissa officinalis L., Thymus pseudopulegioides Klokov et Des., Plantago major L., Rhus L., Hypericum perforatum L., Camellia chinensis L., Taraxacum officinale Wobb., duniperus communis L., etc.. In the present study, the bio-eco-morphological features of some antimicrobial activity plants, their active substance content, their effectuality and usage as traditional medicine in Rize region were discussed. It was observed that these herbs are preferred by experts and they are sold in the neighborhood markets and spice stores, and the local people are quite interested in these medicinal herbs.展开更多
AIM： To determine if the fraction of Nardostachysjata- mansi （N J） has the potential to ameliorate the severity of acute pancreatitis （AP）. METHODS： Mice were administered the biologically active fraction of N J...AIM： To determine if the fraction of Nardostachysjata- mansi （N J） has the potential to ameliorate the severity of acute pancreatitis （AP）. METHODS： Mice were administered the biologically active fraction of N J, i.e., the 4th fraction （N J4）, intra- peritoneally, and then injected with the stable chole- cystokinin analogue cerulein hourly for 6 h. Six hours after the last cerulein injection, the pancreas, lung, and blood were harvested for morphological examination,measurement of cytokine expression, and examination of neutrophil infiltration. RESULTS： N J4 administration attenuated the sever- ity of AP and lung injury associated with AP. It also reduced cytokine production and neutrophil infiltration and resulted in the in vivo up-regulation of heine oxy- genase-1 （HO-1）. Furthermore, NJ4 and its biologically active fraction, N J4-2 inhibited the cerulein-induced death of acinar cells by inducing HO-1 in isolated pan- creatic acinar cells. CONCLUSION： These results suggest that N J4 may be a candidate fraction offering protection in AP and N J4 might ameliorate the severity of pancreatitis by induc- ing HO-1 expression.展开更多
Dakar area landscape is mainly characterized by the existence of the ＂niaye＂-or agricultural depressions located in the sand dunes system. In these depressions, the top-table of quaternary sand groundwater reaches o...Dakar area landscape is mainly characterized by the existence of the ＂niaye＂-or agricultural depressions located in the sand dunes system. In these depressions, the top-table of quaternary sand groundwater reaches or overflows the soil surface. Because of a recent groundwater level drop, some of the niayes have become runoff-gathering sites. This water ensures various economical, environmental and social services, i.e. urban agriculture, drinking water supply of Dakar and formation of ecosystems supporting biodiversity. Given that rainwater infiltration is the only natural ＂input＂, conception and implemention of rainwater management PPP （Politics, Plan and Program） must necessarily take into account this interrelationl Nowadays, two acute problems are observed in the Dakar area. On the one hand, the niayes are threatened by a hydrological drying process due to the insufficiency of rainwater refill. On the other hand, the dramatic social pressure on the environment has led to the urbanization of these bottom-lands. Furthermore, because of the pluviometry decrease, a worsening of the nuisances （floods and malaria） related to surface waters occurs. Consequently, an appropriate runoff management should integrate both the ＂risk＂ and ＂resource＂ dimensions, thus allowing the protection of natural resources and a secure living environment. According to the limits of＂classicai＂ solutions, this paper provides approach elements for building a sustainability plan focusing on emergent concerns, which would control rainwater in urbanized zones.展开更多
文摘The purpose of this paper was to investigate the possibility of treating C. I. Reactive Blue 19 wastewater by electrochemical oxidation via electrogenerated active chlorine, using metallic oxide coatings （dimensional stable anode, DSA） as anode. The electrolysis for the simulated wastewater was conducted at a constant current. Absorbances at 592 nm and 255 nm were measured to follow the decolorization of the dye and the degradatin of its aromatic ring. After 4 h of electrolysis under the experimental conditions： current density of 15 A·m^-2, 0.2 mol·L^-1 NaCl, 0.1 mol·L^-1 Na2SO4, 0.1 mmol·L^-1 dye, initial pH=6.4 and T=30℃, 100% decolorization of the dye and about 45% degradation of its aromatic ring were achieved, while no obvious change of total organic carbon was observed. The experimental results suggest that the decolorization of the dye and degradation of its aromatic ring were directly affected by current density, temperature, concentrations of the dye and sodium chloride, while slightly affected by initial pH and sodium sulfate concentration; the decolorization of the dye and degradation of its aromatic ring followed pseudo-first-order kinetics; and indirect electrooxidation, using electrogenerated active chlorine, predominated in the electrochemical oxidation.
基金supported by grants(AI094335) from the National Institute of Health and from the Wadsworth Center Scientific Interaction Group
文摘Many flaviviruses are significant human pathogens causing considerable disease burdens,including encephalitis and hemorrhagic fever,in the regions in which they are endemic.A paucity of treatments for flaviviral infections has driven interest in drug development targeting proteins essential to flavivirus replication,such as the viral protease.During viral replication,the flavivirus genome is translated as a single polyprotein precursor,which must be cleaved into individual proteins by a complex of the viral protease,NS3,and its cofactor,NS2B.Because this cleavage is an obligate step of the viral life-cycle,the flavivirus protease is an attractive target for antiviral drug development.In this review,we will survey recent drug development studies targeting the NS3 active site,as well as studies targeting an NS2B/NS3interaction site determined from flavivirus protease crystal structures.
基金Supported by the National Basic Research Program of China(973 Program)(No.2008CB418002)the National Major Science and Technology Program for Water Pollution Control and Treatment(No.2012ZX07103-002)+1 种基金the CAS/SAFEA International Partnership Program for Creative Research Teams of Chinese Academy of Sciences(No.KZZDEW-TZ-08-01)the National Natural Science Foundation of China(No.20807043)
文摘Rice straw is supposed to be an environment-friendly biomaterial for inhibiting the growth of harmful blooms of the cyanobacterium Microcystis aeruginosa. However, its potential mechanism is not well known. To explore this mechanism, the growth, cell viability(esterase activity, membrane potential, and membrane integrity), photosynthesis, and cell size of M. aeruginosa were determined using fl ow cytometry and Phyto-PAM after exposure to rice straw extracts(RSE). The results show that doses from 2.0 to 10.0 g/L of RSE effi ciently inhibited the alga for 15 days, while the physiologic and morphologic responses of the cyanobacteria were time-dependent. RSE interfered with the cell membrane potential, cell size, and in vivo chlorophyll- a fl uorescence on the fi rst day. After 7 days of exposure, RSE was transported into the cytosol, which disrupted enzyme activity and photosynthesis. The cyanobacteria then started to repair its physiology(enzyme activity, photosynthesis) and remained viable, suggesting that rice straw act as an algistatic agent.
基金Project(2009T100100602) supported by the Korea Institute of Energy Technology Evaluation and Planning,Korea
文摘A solution of 0.1 mol/L to 1.0 mol/L H2SO4 can dissolve alkali metals and alkaline earth metals which weaken an active site of SCR catalyst. The waste catalyst washed with 0.5 mol/L H2SO4 regained the best catalytic activity. When a concentration of the sulfuric acid is less than 0.5 mol/L, sufficient cleaning effects cannot be obtained. In contrast, when the concentration is greater than 1.0 tool/L, the active components, vanadium and tungsten are undesirably eluted. The total BET surface of the catalyst regenerated by air lift loop reactor showed almost the same as that of fresh catalyst due to the removal of insoluble compounds which may be penetrated into pores of catalyst. The addition of a solution of 0.075 mol/L ammonium vanadate （NHnVO3） and 0.075 mol/L ammonium paratungstate （5（NH4）20· 12WO3-5H20） to 0.1 mol/L H2SO4 significantly increases the activity of the waste catalyst.
文摘In spite the fact that Emily Elizabeth Dickinson lived during the 19th century Amherst among conservative community that gave less chance to female voice to gain a share in social and political life, she paved the way for the coming female thinkers to obtain more freedom of thought and expression. In other words, since she was convient that ＂Abdiction of Belief makes the Behaviour Small＂, she undercut social conventions and moved under gradual shift from Orthodox Trinitarianism into new thoughts of liberalism. However, in good deal of her work, she still pertains to religious conservatism in wider sense than Amhest Church had been dectated.
文摘Rize has a different and special flora because of its geographical position, climate, and topography. The natural plants of Rize have a very big usage potential and value in some sort of intrustrial branches. In particular, the antimicrobial activity of natural plant oils and extracts has formed the basis of many applications, including raw and processed food preservation, pharmaceuticals, alternative medicine and natural therapies： These natural plants can be listed as follows： Artemisia absinthium L., Achi[[ea millefolium L., Astragalus schizopterus Boiss, Ajuga orientalis L., Humulus lupulus L,, Mentha longifolia L., Melissa officinalis L., Thymus pseudopulegioides Klokov et Des., Plantago major L., Rhus L., Hypericum perforatum L., Camellia chinensis L., Taraxacum officinale Wobb., duniperus communis L., etc.. In the present study, the bio-eco-morphological features of some antimicrobial activity plants, their active substance content, their effectuality and usage as traditional medicine in Rize region were discussed. It was observed that these herbs are preferred by experts and they are sold in the neighborhood markets and spice stores, and the local people are quite interested in these medicinal herbs.
基金Supported by The Ministry of Education,Science and Technology at Wonkwang University,No. MEST 2010-0017094
文摘AIM： To determine if the fraction of Nardostachysjata- mansi （N J） has the potential to ameliorate the severity of acute pancreatitis （AP）. METHODS： Mice were administered the biologically active fraction of N J, i.e., the 4th fraction （N J4）, intra- peritoneally, and then injected with the stable chole- cystokinin analogue cerulein hourly for 6 h. Six hours after the last cerulein injection, the pancreas, lung, and blood were harvested for morphological examination,measurement of cytokine expression, and examination of neutrophil infiltration. RESULTS： N J4 administration attenuated the sever- ity of AP and lung injury associated with AP. It also reduced cytokine production and neutrophil infiltration and resulted in the in vivo up-regulation of heine oxy- genase-1 （HO-1）. Furthermore, NJ4 and its biologically active fraction, N J4-2 inhibited the cerulein-induced death of acinar cells by inducing HO-1 in isolated pan- creatic acinar cells. CONCLUSION： These results suggest that N J4 may be a candidate fraction offering protection in AP and N J4 might ameliorate the severity of pancreatitis by induc- ing HO-1 expression.
文摘Dakar area landscape is mainly characterized by the existence of the ＂niaye＂-or agricultural depressions located in the sand dunes system. In these depressions, the top-table of quaternary sand groundwater reaches or overflows the soil surface. Because of a recent groundwater level drop, some of the niayes have become runoff-gathering sites. This water ensures various economical, environmental and social services, i.e. urban agriculture, drinking water supply of Dakar and formation of ecosystems supporting biodiversity. Given that rainwater infiltration is the only natural ＂input＂, conception and implemention of rainwater management PPP （Politics, Plan and Program） must necessarily take into account this interrelationl Nowadays, two acute problems are observed in the Dakar area. On the one hand, the niayes are threatened by a hydrological drying process due to the insufficiency of rainwater refill. On the other hand, the dramatic social pressure on the environment has led to the urbanization of these bottom-lands. Furthermore, because of the pluviometry decrease, a worsening of the nuisances （floods and malaria） related to surface waters occurs. Consequently, an appropriate runoff management should integrate both the ＂risk＂ and ＂resource＂ dimensions, thus allowing the protection of natural resources and a secure living environment. According to the limits of＂classicai＂ solutions, this paper provides approach elements for building a sustainability plan focusing on emergent concerns, which would control rainwater in urbanized zones.
