The prevalence of obesity is growing to epidemic proportions,and there is clearly a need for minimally invasive therapies with few adverse effects that allow for sustained weight loss.Behavior and lifestyle therapy ar...The prevalence of obesity is growing to epidemic proportions,and there is clearly a need for minimally invasive therapies with few adverse effects that allow for sustained weight loss.Behavior and lifestyle therapy are safe treatments for obesity in the short term,but the durability of the weight loss is limited.Although promising obesity drugs are in development,the currently available drugs lack efficacy or have unacceptable side effects.Surgery leads to long-term weight loss,but it is associated with morbidity and mortality.Gastric electrical stimulation(GES) has received increasing attention as a potential tool for treating obesity and gastrointestinal dysmotility disorders.GES is a promising,minimally invasive,safe,and effective method for treating obesity.External gastric pacing is aimed at alteration of the motility of the gastrointestinal tract in a way that will alter absorption due to alteration of transit time.In addition,data from animal models and preliminary data from human trials suggest a role for the gut-brain axis in the mechanism of GES.This may involve alteration of secretion of hormones associated with hunger or satiety.Patient selection for gastric stimulation therapy seems to be an important determinant of the treatment's outcome.Here,we review the current status,potential mechanisms of action,and possible future applications of gastric stimulation for obesity.展开更多
In the era of rapid development of the Intemet, people began to adapt to the huge growth of the Internet to facilitate people＇ s daily lives, people have been accustomed to staying at home and can easily enjoy the co...In the era of rapid development of the Intemet, people began to adapt to the huge growth of the Internet to facilitate people＇ s daily lives, people have been accustomed to staying at home and can easily enjoy the convenience and needs of life to achieve quick and easy lifestyle. The advent of the Internet age also become more virtual to business models, and now the development of enterprises has involved the application of e-commerce technology, the company＇ s business model combines network through electronic technology to some extent, and it made great adjustments and changes in order to deal with the new face of increasingly fierce competition in the market. Thus a new term： ＂E-commerce＂ is well known and accepted as more and more people. A regional economic development need of the residents＇ daily consumption is driven, so local governments need to focus on the various steady development of local small and medium enterprises. Therefore, the development of electronic commerce network technology can indirectly affect a region＇ s economic development. This paper discusses this issue.展开更多
文摘The prevalence of obesity is growing to epidemic proportions,and there is clearly a need for minimally invasive therapies with few adverse effects that allow for sustained weight loss.Behavior and lifestyle therapy are safe treatments for obesity in the short term,but the durability of the weight loss is limited.Although promising obesity drugs are in development,the currently available drugs lack efficacy or have unacceptable side effects.Surgery leads to long-term weight loss,but it is associated with morbidity and mortality.Gastric electrical stimulation(GES) has received increasing attention as a potential tool for treating obesity and gastrointestinal dysmotility disorders.GES is a promising,minimally invasive,safe,and effective method for treating obesity.External gastric pacing is aimed at alteration of the motility of the gastrointestinal tract in a way that will alter absorption due to alteration of transit time.In addition,data from animal models and preliminary data from human trials suggest a role for the gut-brain axis in the mechanism of GES.This may involve alteration of secretion of hormones associated with hunger or satiety.Patient selection for gastric stimulation therapy seems to be an important determinant of the treatment's outcome.Here,we review the current status,potential mechanisms of action,and possible future applications of gastric stimulation for obesity.
文摘In the era of rapid development of the Intemet, people began to adapt to the huge growth of the Internet to facilitate people＇ s daily lives, people have been accustomed to staying at home and can easily enjoy the convenience and needs of life to achieve quick and easy lifestyle. The advent of the Internet age also become more virtual to business models, and now the development of enterprises has involved the application of e-commerce technology, the company＇ s business model combines network through electronic technology to some extent, and it made great adjustments and changes in order to deal with the new face of increasingly fierce competition in the market. Thus a new term： ＂E-commerce＂ is well known and accepted as more and more people. A regional economic development need of the residents＇ daily consumption is driven, so local governments need to focus on the various steady development of local small and medium enterprises. Therefore, the development of electronic commerce network technology can indirectly affect a region＇ s economic development. This paper discusses this issue.
