The activation of Ca2+ entry through store-operated channels by agonists that deplete Ca2+ from the endoplasmic reticulum (ER) is a ubiquitous signaling mechanism, the molecular basis of which has remained elusive for...The activation of Ca2+ entry through store-operated channels by agonists that deplete Ca2+ from the endoplasmic reticulum (ER) is a ubiquitous signaling mechanism, the molecular basis of which has remained elusive for the past two decades. Store-operated Ca2+-release-activated Ca2+ (CRAC) channels constitute the sole pathway for Ca2+ entry following antigen-receptor engagement. In a set of breakthrough studies over the past two years, stromal interaction molecule 1 (STIM1, the ER Ca2+ sensor) and Orai1 (a pore-forming subunit of the CRAC channel) have been identified. Here we review these recent studies and the insights they provide into the mechanism of store-operated Ca2+ channels (SOCCs).展开更多
Since the 1980s, people＇ s material and spiritual life are constantly enriched and improved. People＇ s values are constantly changing, more and more people realize that participate in physical exercise for their own...Since the 1980s, people＇ s material and spiritual life are constantly enriched and improved. People＇ s values are constantly changing, more and more people realize that participate in physical exercise for their own importance in sports. The status of people＇ s lives has been greatly improved, for most residents; they participate in physical activity and have gradually become a richer cultural life, and they enhance the basic needs of physical, mental lifelong sports have gradually deep heart. While people continue to enhance the sports consciousness exercise, we also see some potential problems, such as the rapid development of science and technology is to bring more and more problems to people. As people, enjoy the level of automation in the material aspects of life. They gradually have cars, telephones, washing machines, refrigerators, microwave ovens, rice cookers. And the household products go into our lives, we enjoy the material on those by making more and more people gradually reduce the daily activities. And the most prominent is the elevators and cars, reducing active time and the amount of activity, a lot of heat stored in the human body is causing various diseases, from the results of medical research over the past decade. Various diseases associated with obesity have been become the most important factor in human deaths worldwide, the rapid emergence of this disease and the rapid development of social science and technology form a clear lack of coordination, for which many experts at home and abroad for such issues of deep study and research.展开更多
We consider the relevance of computer hardware and simulations not only to science and technology but also to social life. Evolutionary processes are part of all we know, from the physical and inanimate world to the s...We consider the relevance of computer hardware and simulations not only to science and technology but also to social life. Evolutionary processes are part of all we know, from the physical and inanimate world to the simplest or most complex biological system. Evolution is manifested by land mark discoveries which deeply affect our social life. Demographic pressure, demand for improved living standards and devastation of the natural environment pose new and complex challenges. We believe that the implementation of new computational models based on the latest scientific methodology can provide a reasonable chance of overcoming today's social problems. To ensure this goal, however, we need a change of mindset, placing findings obtained from modern science above traditional concepts and beliefs. In particular, the type of modeling used with success in computational sciences must be extended to allow simulations of novel models for social life.展开更多
文摘The activation of Ca2+ entry through store-operated channels by agonists that deplete Ca2+ from the endoplasmic reticulum (ER) is a ubiquitous signaling mechanism, the molecular basis of which has remained elusive for the past two decades. Store-operated Ca2+-release-activated Ca2+ (CRAC) channels constitute the sole pathway for Ca2+ entry following antigen-receptor engagement. In a set of breakthrough studies over the past two years, stromal interaction molecule 1 (STIM1, the ER Ca2+ sensor) and Orai1 (a pore-forming subunit of the CRAC channel) have been identified. Here we review these recent studies and the insights they provide into the mechanism of store-operated Ca2+ channels (SOCCs).
文摘Since the 1980s, people＇ s material and spiritual life are constantly enriched and improved. People＇ s values are constantly changing, more and more people realize that participate in physical exercise for their own importance in sports. The status of people＇ s lives has been greatly improved, for most residents; they participate in physical activity and have gradually become a richer cultural life, and they enhance the basic needs of physical, mental lifelong sports have gradually deep heart. While people continue to enhance the sports consciousness exercise, we also see some potential problems, such as the rapid development of science and technology is to bring more and more problems to people. As people, enjoy the level of automation in the material aspects of life. They gradually have cars, telephones, washing machines, refrigerators, microwave ovens, rice cookers. And the household products go into our lives, we enjoy the material on those by making more and more people gradually reduce the daily activities. And the most prominent is the elevators and cars, reducing active time and the amount of activity, a lot of heat stored in the human body is causing various diseases, from the results of medical research over the past decade. Various diseases associated with obesity have been become the most important factor in human deaths worldwide, the rapid emergence of this disease and the rapid development of social science and technology form a clear lack of coordination, for which many experts at home and abroad for such issues of deep study and research.
文摘We consider the relevance of computer hardware and simulations not only to science and technology but also to social life. Evolutionary processes are part of all we know, from the physical and inanimate world to the simplest or most complex biological system. Evolution is manifested by land mark discoveries which deeply affect our social life. Demographic pressure, demand for improved living standards and devastation of the natural environment pose new and complex challenges. We believe that the implementation of new computational models based on the latest scientific methodology can provide a reasonable chance of overcoming today's social problems. To ensure this goal, however, we need a change of mindset, placing findings obtained from modern science above traditional concepts and beliefs. In particular, the type of modeling used with success in computational sciences must be extended to allow simulations of novel models for social life.
