Metastatic gastric cancer remains an incurable disease,with a relative 5-year survival rate of 7%-27%.Chemotherapy,which improves overall survival(OS) and quality of life,is the main treatment option.Metaanalysis has ...Metastatic gastric cancer remains an incurable disease,with a relative 5-year survival rate of 7%-27%.Chemotherapy,which improves overall survival(OS) and quality of life,is the main treatment option.Metaanalysis has demonstrated that the best survival results obtained in earlier randomized studies were achieved with three-drug regimens containing a fluoropyrimidine,an anthracycline,and cisplatin(ECF).Although there has been little progress in improving median OS times beyond the 9-mo plateau achievable with the standard regimens,the availability of newer agents has provided some measure of optimism.A number of new combinations incorporating docetaxel,oxaliplatin,capecitabine,and S-1 have been explored in randomized trials.Some combinations,such as epirubicin-oxaliplatin-capecitabine,have been shown to be as effective as(or perhaps more effective than) ECF,and promising early data have been derived for S-1 in combination with cisplatin.One factor that might contribute to extending median OS is the advancement whenever possible to second-line cytotoxic treatments.However,the biggest hope for signif icant survival advances in the near future would be the combination of new targeted biological agents with existing chemotherapy f irst-line regimens.展开更多
World food production and its economic have rapidly grown over a decade; and number of supply chain management research has also increased in this field. However, this development relates to natural resources depletio...World food production and its economic have rapidly grown over a decade; and number of supply chain management research has also increased in this field. However, this development relates to natural resources depletion and deterioration of quality of life in rural population, especially in smallholder farmers. Thailand has practiced the New Theory Agriculture （NTA）, one application aligned with sufficient economy. This theory not only remedies damaged natural resources but also helps smallholder farmers to improve quality of life; and it is analogous to local food supply chain theory, that is well-known in western countries. However, NTA has not been measured its sustainability. Following sustainable food criteria and sustainable agriculture criteria, this paper uses an Indicator of Sustainable Agricultural Practice （ISAP） to measure sustainability at farm level of small rural community＇s network called Inpaeng, a case study that has practiced NTA. The result of assessment in this case implies that NTA yields sustainability to local food supply chain more than monocrop system.展开更多
文摘Metastatic gastric cancer remains an incurable disease,with a relative 5-year survival rate of 7%-27%.Chemotherapy,which improves overall survival(OS) and quality of life,is the main treatment option.Metaanalysis has demonstrated that the best survival results obtained in earlier randomized studies were achieved with three-drug regimens containing a fluoropyrimidine,an anthracycline,and cisplatin(ECF).Although there has been little progress in improving median OS times beyond the 9-mo plateau achievable with the standard regimens,the availability of newer agents has provided some measure of optimism.A number of new combinations incorporating docetaxel,oxaliplatin,capecitabine,and S-1 have been explored in randomized trials.Some combinations,such as epirubicin-oxaliplatin-capecitabine,have been shown to be as effective as(or perhaps more effective than) ECF,and promising early data have been derived for S-1 in combination with cisplatin.One factor that might contribute to extending median OS is the advancement whenever possible to second-line cytotoxic treatments.However,the biggest hope for signif icant survival advances in the near future would be the combination of new targeted biological agents with existing chemotherapy f irst-line regimens.
文摘World food production and its economic have rapidly grown over a decade; and number of supply chain management research has also increased in this field. However, this development relates to natural resources depletion and deterioration of quality of life in rural population, especially in smallholder farmers. Thailand has practiced the New Theory Agriculture （NTA）, one application aligned with sufficient economy. This theory not only remedies damaged natural resources but also helps smallholder farmers to improve quality of life; and it is analogous to local food supply chain theory, that is well-known in western countries. However, NTA has not been measured its sustainability. Following sustainable food criteria and sustainable agriculture criteria, this paper uses an Indicator of Sustainable Agricultural Practice （ISAP） to measure sustainability at farm level of small rural community＇s network called Inpaeng, a case study that has practiced NTA. The result of assessment in this case implies that NTA yields sustainability to local food supply chain more than monocrop system.
