Environmental problems caused by the development of nanotechnology have threatened human health. Investigating the biomedical effects of nanomaterials can help to solve these environmental safety issues. In studies on...Environmental problems caused by the development of nanotechnology have threatened human health. Investigating the biomedical effects of nanomaterials can help to solve these environmental safety issues. In studies on the biomedical effects of nanomaterials, several types of novel nanoscale probes that allow reliable, sensitive, accurate and rapid biomedical detection have emerged. We summarize recent developments in three categories of these nanoprobes, including noble metal nanocluster probes, carbon-based nanostructured probes, and unnatural amino acid-based probes. Besides reviewing the utility of different nanoprobes in cell imaging and protein detection, we also discuss the molecular mechanism of nanoprobe detection. Perspectives of novel nanoprobe design based on molecular details of biomedical detection are presented.展开更多
Shape-memory effect(SME) is the ability of a material to change its dimension in a predefined way in response to an external stimulus. Polymers that exhibit SME are an important class of materials in medicine, especia...Shape-memory effect(SME) is the ability of a material to change its dimension in a predefined way in response to an external stimulus. Polymers that exhibit SME are an important class of materials in medicine, especially for minimally invasive deployment of devices. However, the rate of translation of the concept to approved products is extremely low, with mostly nitinolbased devices being approved. In this review, the general aspects of the different types of stimuli that can be used to activate SME are reviewed and sterilization issues of shape-memory polymer(SMP)-based medical devices are addressed. In addition, the general usefulness as well as the limitations of the shape-memory effect for biomedical applications are described.展开更多
Bright tunable light emission in the short wavelength range from sulfur nanodots was demonstrated with a photoluminescence quantum yield(PLQY)of up to 59.4%.A fission-aggregation mechanism was proposed for the formati...Bright tunable light emission in the short wavelength range from sulfur nanodots was demonstrated with a photoluminescence quantum yield(PLQY)of up to 59.4%.A fission-aggregation mechanism was proposed for the formation of sulfur nanodots with desired performances.This synthetic strategy allowed for simultaneous size control from 3.2 to 5.6 nm,thus tuning the emission color from ultraviolet(UV)to deep blue(342±430 nm),and for the suppression of unwanted nonradiative recombination centers and deep level emission.The luminescence mechanism and quantum confinement effect of the synthesized sulfur nanodots were investigated by optical spectroscopy and theoretical calculations.These results show promise toward the application of sulfur nanodots in UV optoelectronics,biomedical treatments,and sterilization.展开更多
基金supported by the National Natural Science Foundation of China(No8177085581670422)+2 种基金the Taishan Scholars Foundation of Shandong ProvinceChina(No.ts201511057tsqn20161045)
基金the National Natural Science Foundation of China (11404333, 31571026)the National Key Basic Research Program of China (2013CB933704)
文摘Environmental problems caused by the development of nanotechnology have threatened human health. Investigating the biomedical effects of nanomaterials can help to solve these environmental safety issues. In studies on the biomedical effects of nanomaterials, several types of novel nanoscale probes that allow reliable, sensitive, accurate and rapid biomedical detection have emerged. We summarize recent developments in three categories of these nanoprobes, including noble metal nanocluster probes, carbon-based nanostructured probes, and unnatural amino acid-based probes. Besides reviewing the utility of different nanoprobes in cell imaging and protein detection, we also discuss the molecular mechanism of nanoprobe detection. Perspectives of novel nanoprobe design based on molecular details of biomedical detection are presented.
文摘Shape-memory effect(SME) is the ability of a material to change its dimension in a predefined way in response to an external stimulus. Polymers that exhibit SME are an important class of materials in medicine, especially for minimally invasive deployment of devices. However, the rate of translation of the concept to approved products is extremely low, with mostly nitinolbased devices being approved. In this review, the general aspects of the different types of stimuli that can be used to activate SME are reviewed and sterilization issues of shape-memory polymer(SMP)-based medical devices are addressed. In addition, the general usefulness as well as the limitations of the shape-memory effect for biomedical applications are described.
基金financially supported by A*STAR(AME-IRG-A20E5c0083)the National Natural Science Foundation of China(52006005)。
文摘Bright tunable light emission in the short wavelength range from sulfur nanodots was demonstrated with a photoluminescence quantum yield(PLQY)of up to 59.4%.A fission-aggregation mechanism was proposed for the formation of sulfur nanodots with desired performances.This synthetic strategy allowed for simultaneous size control from 3.2 to 5.6 nm,thus tuning the emission color from ultraviolet(UV)to deep blue(342±430 nm),and for the suppression of unwanted nonradiative recombination centers and deep level emission.The luminescence mechanism and quantum confinement effect of the synthesized sulfur nanodots were investigated by optical spectroscopy and theoretical calculations.These results show promise toward the application of sulfur nanodots in UV optoelectronics,biomedical treatments,and sterilization.
