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研究弱磁场生物效应的新途径—建立电子通道模型
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作者 沈海燕 《济宁师范专科学校学报》 2000年第6期38-39,共2页
:简要回顾了对弱磁场生物效应机理的几种解释及存在的问题 .提出了研究该机理的新途径 -建立电子通道模型 。
关键词 磁场生物效应 低频弱磁场 电子通道模型 作用机理 生物细胞 生物大分子构象 电导率
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On the stochastic dynamics of molecular conformation
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作者 DENG Mao-lin ZHU Wei-qiu 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2007年第9期1401-1407,共7页
An important functioning mechanism of biological macromolecules is the transition between different conformed states due to thermal fluctuation. In the present paper, a biological macromolecule is modeled as two stran... An important functioning mechanism of biological macromolecules is the transition between different conformed states due to thermal fluctuation. In the present paper, a biological macromolecule is modeled as two strands with side chains facing each other, and its stochastic dynamics including the statistics of stationary motion and the statistics of conformational transition is studied by using the stochastic averaging method for quasi Hamikonian systems. The theoretical results are confirmed with the results from Monte Carlo simulation. 展开更多
关键词 Biological macromolecule Thermal fluctuation Stationary statistics Transition time Stochastic averaging method
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Quantum theory on protein folding 被引量:4
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作者 LUO LiaoFu 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2014年第3期458-468,共11页
The conformational change of biological macromolecule is investigated from the point of quantum transition.A quantum theory on protein folding is proposed.Compared with other dynamical variables such as mobile electro... The conformational change of biological macromolecule is investigated from the point of quantum transition.A quantum theory on protein folding is proposed.Compared with other dynamical variables such as mobile electrons,chemical bonds and stretching-bending vibrations the molecular torsion has the lowest energy and can be looked as the slow variable of the system.Simultaneously,from the multi-minima property of torsion potential the local conformational states are well defined.Following the idea that the slow variables slave the fast ones and using the nonadiabaticity operator method we deduce the Hamiltonian describing conformational change.It is shown that the influence of fast variables on the macromolecule can fully be taken into account through a phase transformation of slow variable wave function.Starting from the conformation-transition Hamiltonian the nonradiative matrix element was calculated and a general formulas for protein folding rate was deduced.The analytical form of the formula was utilized to study the temperature dependence of protein folding rate and the curious non-Arrhenius temperature relation was interpreted.By using temperature dependence data the multi-torsion correlation was studied.The decoherence time of quantum torsion state is estimated.The proposed folding rate formula gives a unifying approach for the study of a large class problems of biological conformational change. 展开更多
关键词 conformational change of macromolecule quantum transition torsion potential slow variable nonadiabaticity opera-tor Berry's phase quantum decoherence time protein folding
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