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Cytological and Molecular Identification of Alien Chromatin in Giant Spike Wheat Germplasm 被引量:7
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作者 窦全文 陈佩度 解俊峰 《Acta Botanica Sinica》 CSCD 2003年第9期1109-1115,共7页
Alien chromosomes of twelve giant spike wheat germplasm lines were identified by C-banding, genomic in situ hybridization (GISH), sequence characterized amplified region (SCAR), and random amplified polymorphic DNA (R... Alien chromosomes of twelve giant spike wheat germplasm lines were identified by C-banding, genomic in situ hybridization (GISH), sequence characterized amplified region (SCAR), and random amplified polymorphic DNA (RAPD). All lines showed a chromosome number of 2n = 42, five of them carried both a pair of wheat-rye (Triticum aestivum-Secale cereal) 1BL/1RS translocation chromosomes and a pair of Agropyron intermedium (Ai) chromosomes, three carried a pair of Ai chromosomes only, three others carried a pair of 1BL/1RS chromosomes only, and one carried neither 1BL/1BS nor Ai chromosome. Further identification revealed that the identical Ai chromosome in these germplasm lines substituted the chromosome 2D of common wheat (T aestivum L.), designated as 2Ai. The genetic implication and further utilization of 2Ai in wheat improvement were also discussed. 展开更多
关键词 giant spike germplasm 1 BL/1 RS Agropyron intermedium C-banding genomic in situ hybridization (GISH) sequence characterized amplified region (SCAR) random amplified polymorphic DNA (RAPD)
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Pharmacogenetics, pharmacogenomics and ecogenetics 被引量:1
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作者 MOTULSKY Amo G. QI Ming 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2006年第2期169-170,共2页
Pharmacogenetics and pharmacogenomics deal with the role of genetic factors in drug effectiveness and adverse drug reactions. The promise of a personalized medicine is beginning to be explored but requires much more c... Pharmacogenetics and pharmacogenomics deal with the role of genetic factors in drug effectiveness and adverse drug reactions. The promise of a personalized medicine is beginning to be explored but requires much more clinical and translational research. Specific DNA abnormalities in some cancers already have led to effective targeted treatments. Racially determined frequency differences in pharmacogenetic traits may affect choice of treatment requiring specific testing rather than basing treatments according to racial designation. The role of genes in variable responses to foreign chemicals (xenobiotics) has been termed ecogenetics or toxicogenetics raising problems in public health and occupational medicine. Nutrigenetics refers to genetic variation in response to nutrients and may affect nutritional requirements and predisposition to chronic disease. 展开更多
关键词 PHARMACOGENETICS PHARMACOGENOMICS Ecogenetics NUTRIGENETICS Adverse drug reactions
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A new model of corporate DNA
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作者 Li Xianbai 《Ecological Economy》 2007年第2期168-178,共11页
This paper has researched on six kinds of the corporate DNA models, which have set up and analyzed its limitations, regarded the corporation as a vital organism, and put forward the judging standard for corporate DNA ... This paper has researched on six kinds of the corporate DNA models, which have set up and analyzed its limitations, regarded the corporation as a vital organism, and put forward the judging standard for corporate DNA by analogism. According to the standard, the components of the corporate DNA are judged and a new model has been established. The corporate DNA is composed of four DNA chains, which overlap and intercross in the model. Based on the new model, the concept of the corporate central dogma is put forward. The element and information transmission way of corporate information are discussed in the corporate central dogma. 展开更多
关键词 Corporate DNA New model Four DNA chains Corporate central dogma
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HE4 mRNA在卵巢癌中的表达及临床意义的研究 被引量:1
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作者 陈颖 张岩 蒋宏颉 《中国误诊学杂志》 CAS 2010年第23期5548-5551,共4页
目的探讨HE4 mRNA表达与卵巢癌临床病理特征关系和临床意义。方法利用RT-PCR方法检测对照组(n=21)、卵巢交界性肿瘤(n=21)和卵巢癌(n=51)组织中HE4 mRNA表达,应用放射免疫法定量测定卵巢癌患者血清CA125含量。结果在卵巢交界性肿瘤和癌... 目的探讨HE4 mRNA表达与卵巢癌临床病理特征关系和临床意义。方法利用RT-PCR方法检测对照组(n=21)、卵巢交界性肿瘤(n=21)和卵巢癌(n=51)组织中HE4 mRNA表达,应用放射免疫法定量测定卵巢癌患者血清CA125含量。结果在卵巢交界性肿瘤和癌组中,HE4 mRNA和血清CA125阳性表达明显高于对照组(P<0.01,P<0.05),HE4 mRNA阳性表达的特异性明显高于血清CA125(P<0.05)。在早期卵巢癌中,HE4 mRNA阳性表达的敏感性明显高于血清CA125(P<0.05)。结论在卵巢癌中HE4 mRNA表达上调,与卵巢癌的发生和病理生物学行为关系密切,可成为区分卵巢良、交界性和恶性肿瘤的重要标志。 展开更多
关键词 卵巢肿瘤/代谢 肿瘤标记 生物学/遗传学 RNA 信使 人类 女(雌)性
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Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells 被引量:10
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作者 Qin FU Chen HE Zheng-rong MAO 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2013年第1期8-24,共17页
Epstein-Barr virus(EBV),a human gammaherpesvirus carried by more than 90% of the world's population,is associated with malignant tumors such as Burkitt's lymphoma(BL),Hodgkin lymphoma,post-transplant lymphoma,... Epstein-Barr virus(EBV),a human gammaherpesvirus carried by more than 90% of the world's population,is associated with malignant tumors such as Burkitt's lymphoma(BL),Hodgkin lymphoma,post-transplant lymphoma,extra-nodal natural killer/T cell lymphoma,and nasopharyngeal and gastric carcinomas in immune-compromised patients.In the process of infection,EBV faces challenges:the host cell environment is harsh,and the survival and apoptosis of host cells are precisely regulated.Only when host cells receive sufficient survival signals may they immortalize.To establish efficiently a lytic or long-term latent infection,EBV must escape the host cell immunologic mechanism and resist host cell apoptosis by interfering with multiple signaling pathways.This review details the apoptotic pathway disrupted by EBV in EBV-infected cells and describes the interactions of EBV gene products with host cellular factors as well as the function of these factors,which decide the fate of the host cell.The relationships between other EBV-encoded genes and proteins of the B-cell leukemia/lymphoma(Bcl) family are unknown.Still,EBV seems to contribute to establishing its own latency and the formation of tumors by modifying events that impact cell survival and proliferation as well as the immune response of the infected host.We discuss potential therapeutic drugs to provide a foundation for further studies of tumor pathogenesis aimed at exploiting novel therapeutic strategies for EBV-associated diseases. 展开更多
关键词 Epstein-Barr virus Bcl family members APOPTOSIS Drugs therapy
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Association between mandibular posterior alveolar morphology and growth pattern in a Chinese population with normal occlusion 被引量:8
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作者 Min HAN Rong-yang WANG +8 位作者 Hong LIU Xiu-juan ZHU Fu-lan WEI Tao LV Na-na WANG Li-hua HU Guo-ju LI Dong-xu LIU Chun-ling WANG 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2013年第1期25-32,共8页
Objective:To investigate the relationship between growth patterns and mandibular posterior tooth-alveolar bone complex morphology in a Chinese population with normal occlusion.Methods:Forty-five patients with normal o... Objective:To investigate the relationship between growth patterns and mandibular posterior tooth-alveolar bone complex morphology in a Chinese population with normal occlusion.Methods:Forty-five patients with normal occlusion(23 males,22 females) were included in this study.Among these patients,20 displayed the vertical growth pattern,and 20 had the horizontal growth pattern,while the remaining patients displayed the average growth pattern.All of the patients underwent dental cone beam computed tomography(CBCT),which included the region of the mandibular posterior teeth and the alveolar.A linear regression analysis and a correlation analysis between the facial height index(FHI) and the alveolar bone morphology were performed.Results:The inclination of the molars,the thickness of the cortical bone,and the height of the mandibular bone differed significantly between patients with the horizontal growth pattern and those with the vertical growth pattern(P<0.05).Significant positive correlations were found between:the FHI and the inclination of the molars;the FHI and the thickness of the cortical bone;and the FHI and the height of the mandibular bone.Conclusions:The mandibular posterior tooth-alveolar bone complex morphology may be affected by growth patterns. 展开更多
关键词 Cone beam computed tomography (CBCT) Growth pattern Alveolar morphology Normal occlusion
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Detecting polygenic selection in marine populations by combining population genomics and quantitative genetics approaches 被引量:2
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作者 Pierre-Alexandre GAGNAIRE Oscar E. GAGGIOTTI 《Current Zoology》 SCIE CAS CSCD 2016年第6期603-616,共14页
Highly fecund marine species with dispersive life-history stages often display large population sizes and wide geographic distribution ranges. Consequently, they are expected to experience reduced genetic drift, effic... Highly fecund marine species with dispersive life-history stages often display large population sizes and wide geographic distribution ranges. Consequently, they are expected to experience reduced genetic drift, efficient selection fueled by frequent adaptive mutations, and high migration loads. This has important consequences for understanding how local adaptation proceeds in the sea. A key issue in this regard, relates to the genetic architecture underlying fitness traits. Theory predicts that adaptation may involve many genes but with a high variance in effect size. Therefore, the effect of selection on allele frequencies may be substantial for the largest effect size loci, but insignificant for small effect genes. In such a context, the performance of population genomic methods to unravel the genetic basis of adaptation depends on the fraction of adaptive genetic variance explained by the cumulative effect of outlier loci. Here, we address some methodological challenges associated with the detection of local adaptation using molecular approaches. We provide an overview of genome scan methods to detect selection, including those assuming complex demographic models that better describe spatial population structure. We then focus on quantitative genetics approaches that search for genotype-phenotype associations at different genomic scales, including genome-wide methods evaluating the cumulative effect of variants. We argue that the limited power of single locus tests can be alleviated by the use of polygenic scores to estimate the joint contribution of candidate variants to phenotypic variation. 展开更多
关键词 local adaptation genome scans quantitative genetics genotype-phenotype association polygenic scores.
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Impact of the next-generation sequencing data depth on various biological result inferences 被引量:3
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作者 HOU Rui YANG ZhenXing +1 位作者 LI MingHui XIAO HuaSheng 《Science China(Life Sciences)》 SCIE CAS 2013年第2期104-109,共6页
Next-generation sequencing(NGS) technologies have revolutionized the field of genomics and provided unprecedented opportunities for high-throughput analysis at the levels of genomics,transcriptomics and epigenetics.Ho... Next-generation sequencing(NGS) technologies have revolutionized the field of genomics and provided unprecedented opportunities for high-throughput analysis at the levels of genomics,transcriptomics and epigenetics.However,the cost of NGS is still prohibitive for many laboratories.It is imperative to address the trade-off between the sequencing depth and cost.In this review,we will discuss the effects of sequencing depth on the detection of genes,quantification of gene expression and discovering of gene structural variants.This will provide readers information on choosing appropriate sequencing depth that best meet the needs of their particular project. 展开更多
关键词 next-generation sequencing DEPTH gene discovery gene expression structure variation next-generation sequencing DEPTH gene discovery gene expression structure variation
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