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基于谱域OCT图像的人眼前节生物学参数自动测量 被引量:1
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作者 陈思思 朱德喜 +1 位作者 马庆凯 沈梅晓 《中华实验眼科杂志》 CAS CSCD 北大核心 2016年第4期345-350,共6页
背景超长扫描深度OCT可应用于人眼前节的完整成像,但是如何快速、精确地从OCT图像中测量得到眼前节结构的生物学参数是目前亟待解决的难题,目前尚无精确自动处理频域OCT图像的理想软件系统。目的研究自行研制的软件自动测量基于超长... 背景超长扫描深度OCT可应用于人眼前节的完整成像,但是如何快速、精确地从OCT图像中测量得到眼前节结构的生物学参数是目前亟待解决的难题,目前尚无精确自动处理频域OCT图像的理想软件系统。目的研究自行研制的软件自动测量基于超长扫描深度OCT图像的人眼前节生物学参数,评估软件自动化算法的精确度和重复性。方法于2013年6—7月在温州医科大学附属眼视光医院纳入10名健康受检者,共20眼,利用自主研发的超长扫描深度OCT获取人眼前节图像,编写自动探测软件对原始图像进行边界分割、图像配准和光学矫正等处理,其中边界分割算法基于图像的轴向亮度梯度信息,并利用最短路径搜索原理优化边界的准确探测。利用该自动化算法获取受检者中央角膜厚度(CCT)、前房深度(ACD)、瞳孔直径(PD)、晶状体厚度(LT)、晶状体前表面曲率半径(LAC)和后表面曲率半径(LPC),通过比较自动和手动测量眼前节各参数的差异以及重复测量值,评估自动化算法的精度和重复性。结果自动测量与手动测量的CCT、ACD、PD、LT、LAC和LPC值比较差异均无统计学意义(P=0.205、0.167、0.285、0.127、0.102、0.074),自动测量与手动测量各眼前节生物学参数值均有较好的一致性(均ICC〉0.75)。自动测量和手动测量测得的CCT、ACD和LT的重复测量值显示ICC〉0.75,自动测量的PD和LAC重复性(ICC=0.793、0.872;COR=2.90、5.79)优于手动测量(ICC:0.631、0.579;COR=5.62、10.46),但LPC自动测量的重复性(ICC=0.663;COR=6.17)稍差于手动测量(ICC=0.794;COR=4.79)。结论本研究组研制的图像测量软件算法自动测量的眼前节生物学参数具有精确度高、重复性好和运行速度快等特点,在实时探测眼前节形态学动态变化的研究中具有重要的应用价值。 展开更多
关键词 生物学测量/方法 光学相干断层扫描/方法 自动数据处理 眼前节/解剖和组织 重复性
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High Accuracy Zoom Magnification Measurement
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作者 曾政东 孙长库 +2 位作者 郑义忠 YAN Mingdong CHANG Sengkeong 《Transactions of Tianjin University》 EI CAS 2010年第4期289-294,共6页
A precise zoom magnification is important for semiconductor industry and biomedical research. A novel measurement method is demonstrated for optical zoom magnification measurement in this paper. The magnification is o... A precise zoom magnification is important for semiconductor industry and biomedical research. A novel measurement method is demonstrated for optical zoom magnification measurement in this paper. The magnification is obtained by pattern correction between barcode image formed by optical zoom and reference image generated by an ideal optical model. Measurement accuracy which is better than 0.06% has been achieved for optical zoom magnification. Compared with traditional concept, the measurement results are only dependent on two line edges. The barcode correlation method can achieve higher accuracy and better robustness by using the information over the whole field of view. 展开更多
关键词 MAGNIFICATION MICROSCOPE optical zoom BARCODE image processing measurement apparatus
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Biomechanism of adhesion in gecko setae 被引量:1
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作者 GUO Ce SUN JiuRong +3 位作者 GE YingBin WANG WenBo WANG DaPeng DAI-ZhenDong 《Science China(Life Sciences)》 SCIE CAS 2012年第2期181-187,共7页
The study of the adhesion of millions of setae on the toes of geckos has been advanced in recent years with the emergence of new technology and measurement methods. The theory of the mechanism of adhesion by van der W... The study of the adhesion of millions of setae on the toes of geckos has been advanced in recent years with the emergence of new technology and measurement methods. The theory of the mechanism of adhesion by van der Waals forces is now accepted and broadly understood. However, this paper presents limitations of this theory and gives a new hypothesis of the biomechanism of gecko adhesion. The findings are obtained through measurements of the magnitude of the adhesion of setae under three different conditions, to show the close relationship between adhesion and status of the setae. They are reinforced by demonstrating two setal structures, follicle cells and hair, the former making the setae capable of producing bioelectrical charges, which play an important role in attachment and detachment processes. It is shown that the abundant muscular tissues at the base of the setae cells, which are controlled by peripheral nerves, are instrumental in producing the foot movement involved in attachment and detachment. Our study will further uncover the adhesion mechanism of geckos, and provide new ideas for designing and fabricating synthetic setae. 展开更多
关键词 gecko setae ADHESION biomechanism MICROSTRUCTURE BIONICS
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