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PCT、CRP动力学评估脓毒血症预后及诊断意义的研究 被引量:14
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作者 李雨佳 毕宏远 高岩 《标记免疫分析与临床》 CAS 2017年第3期250-256,301,共8页
目的观察血清降钙素原(PCT)、C反应蛋白(CRP)及其动力学变化,评估其在严重脓毒症/感染性休克患者的诊断及预后价值。方法本研究采用回顾性分析方法,2014年9月1日至2016年4月30日选择184例ICU中被诊断为严重脓毒症/感染性休克疾病患者,... 目的观察血清降钙素原(PCT)、C反应蛋白(CRP)及其动力学变化,评估其在严重脓毒症/感染性休克患者的诊断及预后价值。方法本研究采用回顾性分析方法,2014年9月1日至2016年4月30日选择184例ICU中被诊断为严重脓毒症/感染性休克疾病患者,检测入院时血清PCT、CRP水平和治疗后第2,第3和第5天的PCT、CRP水平。结果通过ΔPCT、ΔCRP评估PCT、CRP的动力学在存活者与死亡组中有显著性统计学意(ΔPCT2/0,P=0.0001;ΔPCT3/0,P=0.0001;ΔPCT5/0,P=0.0001;ΔCRP2/0,P=0.0069;ΔCRP3/0,P=0.0001;ΔCRP5/0,P=0.0001),在严重脓毒症和感染性休克组中也存在显著差异(PCT5,P=0.007;ΔPCT5/0,P=0.007)。受试者工作特征曲线(ROC)模型显示,ΔPCT3/0(AUC=0.721)、ΔPCT5/0(AUC=0.77)、ΔCRP5/0(AUC=0.766)水平判断严重脓毒症/感染性休克患者预后有较好的临床意义。ΔPCT5/0(0.619)对严重脓毒症或感染性休克有一定的辅助诊断效果,其在ROC曲线上灵敏度、特异性均较高的临界点为0.624,所以,以第5天的血清ΔPCT5/0水平>0.624可作为预测感染性休克的临界点。结论血清中PCT、CRP对严重脓毒症/感染性休克早期有较好的临床诊断及预后价值,其动力学研究可以提高对严重脓毒症/感染性休克诊断及预后评估的敏感性及准确性。 展开更多
关键词 严重脓毒症 感染性休克 生物标志物变化
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Biomarker evidence for paleoenvironmental changes in the southern Yellow Sea over the last 8200 years 被引量:4
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作者 XING Lei ZHAO Meixun +4 位作者 ZHANG Hailong ZHAO Xiaochen ZHAO Xiaohui YANG Zuosheng LIU Chuanlian 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2012年第1期1-11,共11页
Previous studies have indicated that the Yellow Sea underwent significant environmental changes during the Holocene, but many questions remain concerning the timing of the establishment of the modern circulation syste... Previous studies have indicated that the Yellow Sea underwent significant environmental changes during the Holocene, but many questions remain concerning the timing of the establishment of the modern circulation system, which would have major implications for the Yellow Sea ecosystem and carbon cycle. In this study, marine and terrestrial biomarkers were analyzed in Core YE-2 from a muddy area in the southern Yellow Sea to reconstruct Holocene environmental and phytoplankton community change. The content of three individual marine phytoplankton biomarkers (alkenones, brassicasterol and dinosterol) all display a similar trend, and their total contents during the early Holocene (362 ng/g) were lower than those during the mid-late Holocene (991 ng/g). On the other hand, the contents of terrestrial biomarkers (C27+C29+C31n-alkanes) during the early Holocene (1 661 ng/g) were about three times higher than those during the mid-late Holocene (499 ng/g). Our biomarker results suggest that the modern circulation system of the Yellow Sea was established by 5-6 ka, and resulted in higher marine productivity and lower terrestrial organic matter inputs. Biomarker ratios were used to estimate shifts in phytoplankton community structure in response to mid-Holocene (5-6 ka) environmental changes in the Yellow Sea, revealing a transition from a dinoflagellate-diatom dominant community structure during the early Holocene to a coccolithophore-dominant community structure during the mid-late Holocene. 展开更多
关键词 BIOMARKER Yellow Sea muddy area PALEOPRODUCTIVITY phytoplankton community structure
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Biomarker evidence for biotic and environmental change across the Cambrian Series 2–Series 3 boundary at the Wuliu- Zengjiayan section, Guizhou, China 被引量:3
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作者 WANG ChunJiang ZHAO YuanLong +4 位作者 PENG Jin YANG XinLian BAI Jie LIU Yue CHEN Tao 《Science China Earth Sciences》 SCIE EI CAS 2014年第11期2781-2790,共10页
The Wuliu-Zengjiayan section in Jianhe County, Guizhou Province, China has been suggested as a potential Global Stratotype Section and Point(GSSP) for the defined base of Cambrian Series 3. A molecular organic geochem... The Wuliu-Zengjiayan section in Jianhe County, Guizhou Province, China has been suggested as a potential Global Stratotype Section and Point(GSSP) for the defined base of Cambrian Series 3. A molecular organic geochemical study on the Cambrian Series 2Series 3 boundary interval was carried out to reveal the biotic and environmental change during this transition. The hydrocarbons extracted from the Kaili Formation were proved to be indigenous. The various geochemical proxies such as biomarker parameter, δ13Corg, atomic H/C value of kerogen, and TOC content, co-vary along with the sedimentary column, and show a quick and significant change just across the Cambrian Series 2Series 3 boundary. The less abundance of isoprenoid hydrocarbons, the relative enrichment of midchain monomethyl branched alkanes(mmb-alkanes), the relatively negative value of δ13Corg, and the higher TOC contents may suggest that the upper Cambrian Series 2 was deposited in a relatively reducing environment with a higher organic input from cyanobacteria-predominated benthic microbial mats. On the other hand, the relative enrichment of isoprenoid hydrocarbons, the less abundance of mmb-alkanes, the relatively positive value of δ13Corg, the lower TOC contents, and the lower atomic H/C values of kerogen are combined to indicate an enhanced phytoplankton production and an increased oxygen content and nutrients in the ocean during the early Cambrian Series 3, which could have benefited the explosion of the Kaili Biota. The Wuliu-Zengjiayan section may provide a typical case to understand the co-variation of marine microbe, animal, and environment. 展开更多
关键词 Wuliu-Zengjiayan Cambrian Series 2-Series 3 boundary BIOMARKER organic carbon isotope biotic and environmentalchange
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