3-蒈烯资源及其生物活性应用研究进展

综述了3-蒈烯的主要资源及其生物活性应用。3-蒈烯的主要资源为松科植物和一些中草药植物的挥发性天然精油,重要的有长叶松、欧洲赤松、思茅松、白胡椒、九里香和圆叶当归等,一般通过水蒸气蒸馏的方式获得,并以精馏方式进行分离和提纯。3-蒈烯作为中草药中的活性成分可直接利用植物本身,也可以天然精油的形式在医药、农药、化妆品等行业作为中间体或者配方原料使用。

金合欢醇的资源及其生物活性应用研究进展

根据国内外研究报道,综述了金合欢醇的主要资源及其生物活性应用。金合欢醇广 泛存在于植物体的花、叶、茎等部位之中,尤其是在一些中草药植物和香料植物中具有较高含 量。金合欢醇型细毛樟、辛夷花、枇杷叶等是具有较好开发利用前景的重要资源。金合欢醇是 中草药植物的重要活性成分之一,也是一些重要香料植物精油中的主要香料成分之一,因此,在医药、农药、化 妆品和日用化工等需要其生物活性的方面已经得到较多应用,并具有较好的前景。

草蒿脑资源及生物活性应用研究进展

总结草蒿脑的主要资源及其生物活性应用。草蒿脑广泛存在于植物的花序、枝叶、茎、果实、种子等部位,尤其是一些中草药植物和香料植物中具有较高含量。茴香菖蒲、齿叶黄皮、香叶菖蒲、青川椒、紫罗勒、疏毛罗勒、藿香、鱼香草等是具有较好开发利用前景的重要资源。草蒿脑是中草药植物的重要活性之一,也是一些重要香料植物精油中的主要香料成分之一,在医药、农药、食品添加剂和精细化工等需要其生物活性的方面已经得到较多应用,并具有较好的前景。

桦褐孔菌的生物活性及其应用研究

总结桦褐孔菌的多种生物活性,分析从桦褐孔菌中分离的代谢物在药物评价方面的最新进展,并针对桦褐孔菌的实际应用和其活性代谢产物的工业化生产现状进行总结分析,重点阐述桦褐孔菌在抗癌及抗病毒,尤其是在当前新型冠状病毒(SARS-CoV-2)方面的潜力,凸显桦褐孔菌巨大的药理价值和保健作用,为桦褐孔菌的进一步应用研究提供参考。

生物活性肽的功能与应用

生物活性肽具有诸多生理功能,包括血压调节、抗氧化、抗菌和免疫调节等。生物活性肽主要来源于谷物、豆类、乳制品、海洋动物及坚果等。简介谷物、豆类、乳源和水生物来源的生物活性肽;论述肽制剂的相关概念、分类、功能及应用等方面的问题;综述肽制剂作为人的保健品、动物饲料添加剂和药物等在人与动物中的应用现状,并对生物活性肽研发中需要注意的问题进行简要总结。

姜黄色素的生物活性和提取分离研究进展

姜黄色素是植物姜黄的有效成分之一,它具有广泛的药理活性.本文论述了姜黄素的抗菌、抗癌、抗氧化、抗炎等生物活性.综述了从姜黄中提取分离姜黄色素的一系列方法,如酶法提取、微波提取、超声提取、超临界流体提取以及大孔树脂分离,以期为开发利用姜黄提供科学依据.

假交替单胞菌及其胞外生物活性物质研究进展

假交替单胞菌是新建立的一个海洋细菌属,它独特的生物学特性引起了越来越多研究者的关注。简介了假交替单胞菌的分类地位、生态分布等特点,重点阐述了假交替单胞菌生物活性物质的种类及其生物活性,最后对假交替单胞菌的应用前景进行了展望。

普洱茶茶色素的研究进展

本文较全面综述国内外普洱茶茶色素的最新进展,包括茶色素的组成结构、变化特点、理化性质。

Biodiversity and biotechnological potential of mangrove-associated fungi

This review describes the present hot research areas of mangrove-associated fungi, including its biodiversity, ecological roles, novel metabolites productions and biotechnological potential. Mangrove-associated fungi were divided into saprophytic, parasitic and true symbiotic fungi based on its ecological roles. Saprophytic fungi are fundamental to decomposition and energy flow of mangrove, additionally, their potential toxicity also exists. Pathogenic fungi have significant effects on mangrove survival, growth, and fitness. Endophytic fungi, the most prolific source of diverse bioactive compounds found among that of mangrove-associated fungi, are found in most species of mangroves. Although a significant number of reports focused on the antimicrobial, insecticidal and other bioactive metabolites as well as many novel enzymes isolatcd from mangrove-associated fungi, and many of those metabolites from endophytic fungi are suspected to be of significant to mangrove, only few studies have provided convincing evidence for symbiotic producers in mangrove. Hence, this paper discusses the present progress of molecular methods used to correlate the ecological roles of endophytic fungi with their bioactive metabolites;, meanwhile, the potential of using metabolic engineering and post-genomic approaches to isolate more novel enzymes and bioactive compounds and to make their possible commercial application was also discussed.

Angiotensin-（1-7）： new perspectives in atherosclerosis treatment

Angiotensin （Ang）-（1-7） is recognized as a new bioactive peptide in renin-angiotensin system （RAS）. Ang-（1-7） is a counter-regulatory mediator of Ang-II which appears to be protective against cardiovascular disease. Recent studies have found that Ang-（1-7） played an important role in reducing smooth muscle cell proliferation and migration, improving endothelial function and regulating lipid metabolism, leading to inhibition of atherosclerotic lesions and increase of plaque stability. Although clinical application of Ang-（1-7） is restricted due to its pharmacokinetic properties, identification of stabilized compounds, including more stable analogues and specific delivery compounds, has enabled clinical application of Ang-（1-7）. In this review, we discussed recent findings concerning the biological role of Ang-（1-7） and related mechanism during atherosclerosis development. In addition, we highlighted the perspective to develop therapeutic strategies using Ang-（1-7） to treat atherosclerosis.

Application of Biosurfactant from Candida sphaerica UCP 0995 in Removal of Petroleum Derivative from Soil and Sea Water

The biosurfactant produced by Candida sphaerica in a fermentor containing 5% vegetal oil refinery waste and 2.5% was tested in the removal of motor oil from soils and seawater. In kinetic assays, the isolated biosurfactant removed more than 86% of the motor oil adsorbed to clay, silty and sandy soils at the critical micelle concentration （CMC）. Static removal tests performed in glass columns demonstrated that the crude biosurfactant was able to remove 75% and 92% of the oil contained in clay and silty soil, respectively, whereas the isolated biosurfactant at its CMC removed 50% of the oil from sandy soil. In the washing of hydrophobic compound on a porous surface, the removal rate was 60%. The biosurfactant also proved to be efficient in detergency tests since the crude surfactant removed 41% of motor oil from contaminated cotton cloth. In tests carried out with seawater, the crude biosurfactant showed an oil spreading efficiency of 75% in both screening dispersion test and oil displacement efficiency methods. Regarding the swirling bottle test, the dispersion rate was 72% for the isolated biosurfactant at a concentration twice the CMC. The biosurfactant studied demonstrated potential for application as an adjuvant in biotechnological processes for environmental decontamination.

Supramolecular protein glue to boost enzyme activity

Proteins possess many biological functions.However, they can easily degrade or aggregate, thus losing their bioactivity. Therefore, it is very important to develop materials capable of interacting with proteins and forming nanostructures for protein storage and delivery. In this study,we serendipitously found a novel peptide-based supramolecular protein glue(Nap-GFFYK(γE)2-NH2, compound 1) that could co-assemble with proteins into nanofibers and hydrogels. We found that compound 1 rapidly folded into a β-sheet conformation upon contact with many proteins but not with polymers. Total internal reflection fluorescence microscopy(TIRFM) images clearly show the formation of co-assembled nanofibers by proteins and the peptide. The supramolecular protein glue could improve the dispersion of enzymes(lipase and lysozyme) and therefore enhance their catalytic activity,especially at high temperatures. More importantly, the supramolecular protein glue could co-assemble with two enzymes, glucose oxidase/horseradish peroxidase(GOx/HRP)and GOx/cytochrome c(cyt c), to form nanofibers that significantly enhanced the catalytic activity of tandem enzymatic reactions. We envisioned the great potential of our supramolecular protein glue for protein storage, delivery, and bioactivity manipulation.

Three-dimensional bio-printing

Three-dimensional(3D) printing technology has been widely used in various manufacturing operations including automotive, defence and space industries. 3D printing has the advantages of personalization, flexibility and high resolution, and is therefore becoming increasingly visible in the high-tech fields. Three-dimensional bio-printing technology also holds promise for future use in medical applications. At present 3D bio-printing is mainly used for simulating and reconstructing some hard tissues or for preparing drug-delivery systems in the medical area. The fabrication of 3D structures with living cells and bioactive moieties spatially distributed throughout will be realisable. Fabrication of complex tissues and organs is still at the exploratory stage. This review summarize the development of 3D bio-printing and its potential in medical applications, as well as discussing the current challenges faced by 3D bio-printing.