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左金丸及类方HPLC指纹图谱与生物热活性的“谱-效”关系研究 被引量:36
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作者 孔维军 赵艳玲 +2 位作者 山丽梅 肖小河 郭伟英 《化学学报》 SCIE CAS CSCD 北大核心 2008年第22期2533-2538,共6页
HPLC法建立左金丸及类方水提液的特征指纹图谱,计算各特征峰的相对峰面积,并采用中药色谱指纹图谱相似度评价系统A版(2004 A)计算类方间的相似度;微量热法测定大肠杆菌在左金丸及类方水提液作用下的热谱曲线,得到相应的热动力学参数,如... HPLC法建立左金丸及类方水提液的特征指纹图谱,计算各特征峰的相对峰面积,并采用中药色谱指纹图谱相似度评价系统A版(2004 A)计算类方间的相似度;微量热法测定大肠杆菌在左金丸及类方水提液作用下的热谱曲线,得到相应的热动力学参数,如生长速率常数k,最大产热功率Pm,最高峰的出峰时间tm和总产热量Qt等,并对这些热动力学参数进行主成份分析.典型相关分析法对左金丸及类方HPLC指纹图谱中特征峰的相对峰面积与其类方作用下大肠杆菌生长代谢的主要热动力学参数相关联,研究"谱-效"相关性.结果表明,HPLC指纹图谱与生物热活性存在很好的相关性,类方中吴茱萸次碱、盐酸巴马汀、盐酸小檗碱的含量差异是导致其生物热活性不同的主要原因. 展开更多
关键词 左金丸及类方 HPLC指纹图谱 生物热活性 “谱-效”关系
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基于化学特征图谱-生物热活性图谱关联检测的注射用双黄连冻干粉针质量控制方法的初步研究 被引量:16
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作者 张雅铭 鄢丹 +4 位作者 张萍 任永申 张少峰 冯雪 肖小河 《药学学报》 CAS CSCD 北大核心 2010年第1期93-97,共5页
为了建立包括生物热活性检测在内的中药注射剂质量控制方法,本文以注射用双黄连冻干粉针为模式药,建立HPLC-ELSD特征图谱,进行相似度评价;采用微量量热法,建立生物热活性图谱,并提取相关生物热动力学参数(达峰时间Tm2,Tj和抑制率I%),以... 为了建立包括生物热活性检测在内的中药注射剂质量控制方法,本文以注射用双黄连冻干粉针为模式药,建立HPLC-ELSD特征图谱,进行相似度评价;采用微量量热法,建立生物热活性图谱,并提取相关生物热动力学参数(达峰时间Tm2,Tj和抑制率I%),以相关系数法进行相似度评价。结果表明,HPLC-ELSD特征图谱不易区分不同贮藏条件下样品之间的微小差异,特别是对生物污染样品基本无法辨识;生物热活性图谱可以区别高温处理样品及污染变质样品,并可以全面反映模型生物的热生物学信息,提供了专属性较强的二维信息,可作为化学特征图谱的有益补充。本文从质量均一性出发,通过HPLC-ELSD特征图谱和生物热活性图谱关联检测对注射用双黄连冻干粉针进行质量控制,为实现对中药注射剂质量变化的早期快速筛查,预警其不良反应提供了技术参考。 展开更多
关键词 注射用双黄连冻干粉针 HPLC-ELSD 生物热活性图谱 质量控制 均一性
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清开灵注射液生物热活性指纹图谱的初步研究 被引量:9
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作者 武彦舒 张倩 +5 位作者 金城 鄢丹 刘义 肖小河 杜晓曦 王建 《中国药学杂志》 CAS CSCD 北大核心 2009年第6期471-474,共4页
目的研究清开灵注射液作用于金黄色葡萄球菌的生物热活性指纹图谱,探索清开灵注射液质量的生物活性评价新方法。方法采用微量量热法,在合适测试浓度下,分别测定各清开灵注射液样品生物热活性指纹图谱,并进行定性、定量分析。结果不同厂... 目的研究清开灵注射液作用于金黄色葡萄球菌的生物热活性指纹图谱,探索清开灵注射液质量的生物活性评价新方法。方法采用微量量热法,在合适测试浓度下,分别测定各清开灵注射液样品生物热活性指纹图谱,并进行定性、定量分析。结果不同厂家及同厂家不同批次清开灵注射液样品的生物热活性指纹图谱相似度及热动力学参数存在不同程度差异,一个过期样品亦可被区分。结论该方法简便可靠,可为清开灵注射液的质量控制提供参考,为从活性角度研究中药注射液的质量一致性和稳定性提供了一种很好的思路。 展开更多
关键词 微量量 清开灵注射液 金黄色葡萄球菌 生物热活性指纹图谱 一致性 稳定性
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基于生物热活性检测的黏菌素效价测定方法研究 被引量:4
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作者 罗云 鄢丹 +5 位作者 任永申 张少锋 冯雪 李寒冰 唐慧英 肖小河 《药学学报》 CAS CSCD 北大核心 2009年第10期1136-1139,共4页
采用生物热活性检测法,测定黏菌素作用于大肠杆菌的生物热活性谱,并以大肠杆菌生长时间延迟率Δt%为评价指标,建立黏菌素效价测定的新方法。结果显示,在17.0~41.6u·mL-1内,黏菌素浓度的对数值lgC与Δt%具有良好的线性关系(r=0.99... 采用生物热活性检测法,测定黏菌素作用于大肠杆菌的生物热活性谱,并以大肠杆菌生长时间延迟率Δt%为评价指标,建立黏菌素效价测定的新方法。结果显示,在17.0~41.6u·mL-1内,黏菌素浓度的对数值lgC与Δt%具有良好的线性关系(r=0.993);平均回收率为100.3%(n=9),且生物热活性检测法测定结果与管碟法测定结果一致(P>0.05)。结果表明,所建立的生物热活性检测法具有灵敏准确、实时在线、操作简便、干扰因素少、重现性好的特点,可作为黏菌素效价测定方法之一,同时所得生物热活性谱可弥补管碟法对细菌生长过程监控的不足。 展开更多
关键词 生物热活性检测 生物检定 效价 抗生素 黏菌素
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基于四膜虫生物热活性的大黄炮制减毒研究 被引量:5
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作者 李会芳 马永刚 +1 位作者 肖小河 刘义 《中草药》 CAS CSCD 北大核心 2012年第1期103-105,共3页
目的探讨大黄不同炮制品对四膜虫毒性的差异。方法采用微量量热仪考察大黄不同炮制品对四膜虫生物热活性参数的影响。结果大黄不同炮制品对四膜虫生长有不同程度的抑制作用,其作用强度顺序为生大黄>酒大黄>熟大黄>大黄炭;对四... 目的探讨大黄不同炮制品对四膜虫毒性的差异。方法采用微量量热仪考察大黄不同炮制品对四膜虫生物热活性参数的影响。结果大黄不同炮制品对四膜虫生长有不同程度的抑制作用,其作用强度顺序为生大黄>酒大黄>熟大黄>大黄炭;对四膜虫生长的抑制毒性表现为:随着抑制率的增大,传代时间(tG)延长,最大热功率(Pmax)逐渐降低,达最大热功率时间(tmax)逐渐延后;四模虫整个生长过程的产热量不同程度地减少,以生大黄减少的最为明显。结论大黄经炮制后,有明显的减毒作用,四膜虫生物热活性研究可用于中药毒性的早期筛选。 展开更多
关键词 大黄 炮制减毒 四膜虫 微量量 生物热活性
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Cu^(2+)胁迫下湿地微生物热代谢活性及Cu^(2+)的固定/转化率 被引量:2
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作者 江绍锋 蓝运华 +1 位作者 夏樱花 陆祖军 《生态与农村环境学报》 CAS CSCD 北大核心 2014年第3期358-363,共6页
应用微量热法结合常规分析方法,研究了桂林会仙湿地沼泽底泥和水稻田微生物在800~4 000μg·g-1Cu2+胁迫下的热代谢活性及Cu2+的固定/转化率。结果表明,在w(Cu2+)为800μg·g-1条件下,水稻田和沼泽底泥土壤微生物对Cu2+的固定/... 应用微量热法结合常规分析方法,研究了桂林会仙湿地沼泽底泥和水稻田微生物在800~4 000μg·g-1Cu2+胁迫下的热代谢活性及Cu2+的固定/转化率。结果表明,在w(Cu2+)为800μg·g-1条件下,水稻田和沼泽底泥土壤微生物对Cu2+的固定/转化率分别为44.93%和34.59%,但在w(Cu2+)为4 000μg·g-1时则分别是93.16%和85.13%;Cu2+对水稻田和沼泽底泥土壤微生物代谢活性的半抑制浓度分别为2 043和2 325μg·g-1;水稻田土壤微生物代谢活性低于沼泽底泥,在土壤及其微生物共同作用下Cu2+的固定/转化率随Cu2+浓度递增而升高;在相同条件下,水稻田和沼泽底泥土壤微生物的代谢速率在α=0.05或α=0.01水平上显著相关。湿地土壤用途改变后,土壤微生物在固定/转化Cu2+的作用上发生了明显变化。 展开更多
关键词 桂林 会仙湿地 水稻田 沼泽底泥 生物代谢活性 Cu2+固定 转化率
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中药制剂工艺有无质的改变的早期快速检测——基于生物热动力学表征的板蓝根水提物不同干燥方式的抗菌效应差异 被引量:1
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作者 罗云 鄢丹 +3 位作者 金城 王强 刘友平 肖小河 《世界科学技术-中医药现代化》 2009年第3期395-399,共5页
目的:从生物热活性变化的角度,考察不同干燥方式对板蓝根水提物质量的影响,为建立中药制剂工艺有无质的改变的早期快速检测方法体系提供依据。方法:板蓝根水提液分别采用冷冻干燥、减压干燥、常压干燥、喷雾干燥等4种不同方式进行干燥... 目的:从生物热活性变化的角度,考察不同干燥方式对板蓝根水提物质量的影响,为建立中药制剂工艺有无质的改变的早期快速检测方法体系提供依据。方法:板蓝根水提液分别采用冷冻干燥、减压干燥、常压干燥、喷雾干燥等4种不同方式进行干燥。通过测定各干燥样品作用于大肠杆菌的生物热活性图谱并拟合得到生物热动力参数,比较不同样品的抗菌生物活性的差异性。结果:不同干燥方式所得样品的生物热活性存在较大差异,喷雾干燥和冷冻干燥所得样品的作用明显强于减压干燥和常压干燥样品,提示干燥方式的改变对板蓝根水提物质量的影响不容忽视,当板蓝根制剂的干燥工艺从冷冻干燥、喷雾干燥转变成减压干燥或常压干燥时,须注意其生产工艺是否存在质的改变。结论:生物热活性检测具有普适性好、实时在线、灵敏准确、定性定量、经济高效等特点,可作为中药板蓝根水提物不同干燥工艺有无质的改变早期快速检测方法。 展开更多
关键词 生物热活性 板蓝根 水提物 干燥方式 差异性
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喜热噬油芽胞杆菌代谢产生表面活性剂的研究 被引量:1
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作者 王凤兰 王晓东 《微生物学杂志》 CAS CSCD 2007年第5期23-28,共6页
采用丙酮抽提、高压液相分离纯化等技术从嗜热菌Geobacillus therm oleovorans以正十六烷为碳源培养的发酵液中分离获得性能突出的表面活性物质。利用甲脂化、乙酰化衍生技术结合GC-MS,MS(ESI)等鉴定该表面活性剂为单脂肪酸甘油脂。实... 采用丙酮抽提、高压液相分离纯化等技术从嗜热菌Geobacillus therm oleovorans以正十六烷为碳源培养的发酵液中分离获得性能突出的表面活性物质。利用甲脂化、乙酰化衍生技术结合GC-MS,MS(ESI)等鉴定该表面活性剂为单脂肪酸甘油脂。实验条件下,该表面活性剂使水的表面张力降低到32.7 mN/m,测定其临界胶束浓度为41 mg/L。 展开更多
关键词 生物表面活性剂喜噬油芽胞杆菌甘油脂脂肪酸
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基于生物热动力学表征的中药固体制剂体外溶出度分析方法初步研究 被引量:14
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作者 黄雪 袁海龙 +1 位作者 肖小河 张甜甜 《药学学报》 CAS CSCD 北大核心 2010年第3期338-342,共5页
本文采用微量量热法从生物热活性角度、结合UPLC法,首次探讨生物检测中药固体制剂体外溶出度的可行性,旨在弥补单纯化学方法难以客观反映中药固体制剂溶出度检测的不足。以银黄片为模型药,考察在pH6.8(磷酸盐缓冲液)溶出介质中,不同溶... 本文采用微量量热法从生物热活性角度、结合UPLC法,首次探讨生物检测中药固体制剂体外溶出度的可行性,旨在弥补单纯化学方法难以客观反映中药固体制剂溶出度检测的不足。以银黄片为模型药,考察在pH6.8(磷酸盐缓冲液)溶出介质中,不同溶出时间的银黄片溶出液对金葡菌抑制作用,测定金葡菌生长代谢热曲线特征谱图,得到一系列生物热动力学参数,提出基于生物热活性所得银黄片的累积溶出度,并与UPLC法测定绿原酸和黄芩苷两个指标成分所得的溶出度运用f2相似因子法进行相关性评价。结果显示,f2相似因子均大于50,表明两方法所测的溶出度具有较好的相关性。生物热活性检测有望成为中药固体制剂的体外溶出度评价手段之一。 展开更多
关键词 中药固体制剂 溶出度 生物热活性 银黄片
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Antioxidant and isozyme features of two strains of Laminaria japonica (Phaeophyceae) 被引量:2
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作者 王悠 唐学玺 +1 位作者 李永祺 俞志明 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2007年第1期67-72,共6页
Healthy sporophytes of two gametophyte mutants of Laminariajaponica with different heat resistances: kelp 901 (901, with comparatively stronger heat-resistance) and Rongcheng No. I (RC, sensitive to heat stress),... Healthy sporophytes of two gametophyte mutants of Laminariajaponica with different heat resistances: kelp 901 (901, with comparatively stronger heat-resistance) and Rongcheng No. I (RC, sensitive to heat stress), were respectively collected during October to December 2002 from Yantai and Rongcheng Sea Farm in the Shandong Peninsula of China. The contents of some biochemical materials and antioxidant capacity were analyzed under controlled laboratory conditions to identify if there is any relation between the overall antioxidant capacity and the heat-resistance in L. japonica and to understand possible mechanism of heat-resistance. Results show that: (1) the overall antioxidant capacity in healthy sporophyte of 901, such as vitamin E, polyphenol, and ascorbic acid contents and the enzymatic activity of SOD, POD, CAT, Gpx, PPO, and PAL, were not always higher than that of RC under controlled laboratory conditions, and no significance (P〉0.05) was shown in total antioxidant capacity (T-AOC) in 901 and RC. Result suggested that the difference in antioxidant capacity was not a decisive factor for different heat-resistances in L. japonica; (2) the simultaneous assay on isozymes was carried out using vertical polyacrylamide gel electrophoresis (PAGE). Considerable differences in peroxide (PRX), malate dehydrogenase (MDH), malic enzyme (ME), polyphenol oxidase (PPO) and glutamate dehydrogenase (GDH) were obtained in 901 and RC from either the band number, relative mobility (Rf), or staining intensity, and ME could be used as an indicator to distinguish healthy sporophyte of 901 and RC under controlled laboratory conditions. 展开更多
关键词 Laminariajaponica HEAT-RESISTANCE antioxidant system ISOZYME
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Isothermal Microcalorimetry:A Review of Applications in Soil and Environmental Sciences 被引量:9
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作者 RONG Xing-Min HUANG Qiao-Yun JIANG Dai-Hua CAI Peng LIANG Wei 《Pedosphere》 SCIE CAS CSCD 2007年第2期137-145,共9页
Isothermal microcalorimetry provides thermodynamic and kinetic information on various reactions and processes and is thereby a powerful tool to elucidate their mechanisms. Certain improvement in isothermal microcalori... Isothermal microcalorimetry provides thermodynamic and kinetic information on various reactions and processes and is thereby a powerful tool to elucidate their mechanisms. Certain improvement in isothermal microcalorimetry with regard to the studies on soil and environmental sciences is briefly described. This review mainly focuses on the use of microcalorimetry in the determination of soil microbial activity, monitoring the toxicity and biodegradation of soil organic pollutants, the risk evaluation of metals and metalloids, the heat effect of ion exchange and adsorption in soil, and environmental researches. Promising prospects for the applications of the technique in the field are also discussed. 展开更多
关键词 ENVIRONMENT ISOTHERMAL microbial activity MICROCALORIMETRY SOIL
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Importance and Role of Biodiversity and Tropical Forests in the Cultural, Socio-Economic and Religious Life of African Black People: Case of Benin 被引量:1
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作者 Adjovi Edmond Codjo Amadji Togbe Armel Olodo Emmanuel 《Journal of Environmental Science and Engineering(B)》 2017年第6期312-322,共11页
Biodiversity and tropical forests play a fundamental role in the life of the black people of Africa. In Benin, while some aspects of this role are well-documented, others are barely known. Moreover, these information ... Biodiversity and tropical forests play a fundamental role in the life of the black people of Africa. In Benin, while some aspects of this role are well-documented, others are barely known. Moreover, these information remains so far very scattered through the literature which does not allow to have a global view on the contribution of biodiversity and forests to the life of people. In this work, it is presented the role of forests and biological diversity in the main vital areas of life of populations in south of Benin. The methodology used was based, with regard to the field, on bibliographical research, observation and/or field stakeholder survey. Investigations are more particularly focused on hardwood lumber uses and the species that are significantly used. The results highlight the uses that are made of vegetal elements of biological diversity and timber as forest products in south of Benin. The main areas explored are animist or traditional religion and traditional medicine, as well as socio-cultural and economic life. In this latter area, the most used timber species and their uses are identified; these include furniture, light carpentry, sculpture, formwork, canoe construction, drums and mortar making. 展开更多
关键词 BIODIVERSITY forest areas of life African populations wood
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Rheological and Structural Properties of Sea Cucumber Stichopus japonicus During Heat Treatment 被引量:12
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作者 GAO Xin XUE Dongmei +2 位作者 ZHANG Zhaohui XU Jiachao XUE Changhu 《Journal of Ocean University of China》 SCIE CAS 2005年第3期244-247,共4页
Changes in tissue structure, rheological properties and water content of raw and heated sea cucumber meat were studied. Sea cucumber Stichopus japonicus was heated at 25℃, 70℃ and 100℃ water for 5 min. The structur... Changes in tissue structure, rheological properties and water content of raw and heated sea cucumber meat were studied. Sea cucumber Stichopus japonicus was heated at 25℃, 70℃ and 100℃ water for 5 min. The structural changes were observed using a light microscope and the rheological parameters (rupture strength, adhesive strength and deformation) determined using a texture meter. Microscopic photograph revealed that the structural change of heated meat was greater than that of raw meat. The rupture strength, adhesive strength and deformation of raw meat were smaller than those of the heated meat. Meanwhile, rheological parameters showed positive correlation with heating temperature. These changes are mainly caused by thermal denaturation and gelatinization of collagen during heating. These changes were also evidenced in observations using a light microscope and differential scanning calorimetry. 展开更多
关键词 sea cucumber COLLAGEN muscle fibers rheological properties
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基于微量量热法检测注射用双黄连冻干粉针质量波动性的研究 被引量:2
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作者 张雅铭 鄢丹 +4 位作者 张萍 任永申 张少峰 冯雪 肖小河 《中草药》 CAS CSCD 北大核心 2010年第7期1084-1087,共4页
目的从生物检定角度,探索并建立表征注射用双黄连冻干粉针质量波动性的方法。方法采用微量量热法,建立基于痢疾杆菌的注射用双黄连冻干粉针质量波动评价方法,制备避光室温、高温(60℃)及光照(4 500±500)lx样品S1~S9。以生物热活... 目的从生物检定角度,探索并建立表征注射用双黄连冻干粉针质量波动性的方法。方法采用微量量热法,建立基于痢疾杆菌的注射用双黄连冻干粉针质量波动评价方法,制备避光室温、高温(60℃)及光照(4 500±500)lx样品S1~S9。以生物热活性图谱的相似度和微量量热学参数如指数生长期速率常数(k1),最大发热功率(P1)、达峰时间(T1)、发热量(Q1),稳定期最大发热功率(P2)、达峰时间(T2)、发热量(Q2)为评价指标,进行定性定量分析,以生物热活性图谱相似度S、参数T′m、P′m为指标进行聚类分析。结果相似度分析结果显示,与避光室温(22℃)样品S1~S4相比,光照(4 500±500)lx样品S7~S9相似度较高(R>0.85),而高温(60℃)样品S5~S6的生物热活性图谱相似度较低(R≤0.700)。结论以相似度及微量量热学特征参数定性定量表征不同样品的抑菌活性,所建立的生物热活性图谱全面反映模型生物的热生物学信息,提供了专属性较强的二维信息,可作为化学指纹图谱的有益补充,可以用于注射用双黄连冻干粉针的质量波动性检测。 展开更多
关键词 注射用双黄连冻干粉针 微量量 痢疾杆菌 生物热活性图谱 质量波动
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Crystal structures, thermal behavior and biological activities of lanthanide compounds with 2,4-dichlorobenzoic acid and 1,10-phenanthroline 被引量:1
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作者 LIU JingYu REN Ning +2 位作者 ZHANG JianJun ZHANG CunYing SONG HuiHua 《Science China Chemistry》 SCIE EI CAS 2014年第11期1520-1531,共12页
Five new binuclear lanthanide compounds [Ln(2,4-DClBA)3phen]2(Ln = Pr(1), Eu(2), Tb(3), Ho(4) and Er(5); 2,4-DClBA = 2,4-dichlorobenzoate; phen = 1,10-phenanthroline) have been synthesized and structurally characteriz... Five new binuclear lanthanide compounds [Ln(2,4-DClBA)3phen]2(Ln = Pr(1), Eu(2), Tb(3), Ho(4) and Er(5); 2,4-DClBA = 2,4-dichlorobenzoate; phen = 1,10-phenanthroline) have been synthesized and structurally characterized by X-ray crystallography. And all of them were carefully investigated by elemental analysis, molar conductance, IR, UV and TG/DSC-FTIR technology. Single-crystal X-ray diffraction studies revealed that compounds 1–5 were binuclear molecules with an inversion center and the Ln3+ ions contained two kinds of coordination environment that was a distorted monocapped square-antiprism in the compounds 1–2, and a distorted square-antiprism geometry in the compounds 3–5. The 3D surface graphs for the FTIR spectra of gaseous products for the compounds 1–5 were recorded using simultaneous TG/DSC-FTIR technique which is intended to further analysis of the thermal decomposition processes. Hence the gaseous products were identified by the solved single IR spectra obtained at different temperatures from the 3D surface graphs. Furthermore, the Eu(Ш) and Tb(Ш) ternary compounds exhibited intense luminescence under the radiation of UV light. And the results for antimicrobial test show that these compounds exhibit good bacteriostatic activity against Staphylococcus aureus, and better antimicrobial activity against Escherichia coli and Candida albicans. 展开更多
关键词 lanthanide complexes crystal structure bacteriostatic activity thermal properties 2 4-dichlorobenzoic acid
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Chemical Properties and Biochemical Activity of Colonized and Abandoned Litter-Feeding Termite(Macrotermes spp.) Mounds in Chromic Cambisol Area on the Borana Plateau, Ethiopia 被引量:1
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作者 L.MENICHETTI L.LANDI +3 位作者 P.NANNIPIERI T.KATTERER H.KIRCHMANN G.RENELLA 《Pedosphere》 SCIE CAS CSCD 2014年第3期399-407,共9页
Termite (Macrotermes spp.) mounds are complex biological habitats originated by the termite activity and possessing peculiar physical, chemical and biochemical properties. In this study we examined the concentration... Termite (Macrotermes spp.) mounds are complex biological habitats originated by the termite activity and possessing peculiar physical, chemical and biochemical properties. In this study we examined the concentration of nutrients and the biochemical activity of abandoned soil and mounds colonized by termites of the genera Macroterrnes located in the Borana District, Ethiopia. To elucidate the magnitude and persistence of the termite-induced effects, we also studied an abandoned mound, previously colonized by termites of the same genera formed on the same soil. Results confirmed that termite-colonized mounds are 'hot spots' of nutrient concentration and microbial activity in tropical soils. This is due to the termite driven litter input and decomposition. The abandoned mounds showed higher microbial biomass and activity and displayed a nutrient redistribution and a greater microbial activity than the adjacent soils. These findings allowed us to hypothesize a model of nutrient cycling in colonized soils and a partition of the relative roles of termites and soil microorganisms in nutrient location and turnover in tropical soils. These results may be also useful for the optimal management of termite-colonized soils. 展开更多
关键词 enzyme activity microbial activity microbial biomass nutrient cycling nutrient turnover
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Sweet ionic liquids-cyclamates: Synthesis, properties, and application as feeding deterrents
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作者 PERNAK Juliusz WASINSKI Krzysztof +4 位作者 PRACZYK Tadeusz NAWROT Jan CIENIECKA-ROSLONKIEWICZ Anna WALKIEWICZ Filip MATERNA Katarzyna 《Science China Chemistry》 SCIE EI CAS 2012年第8期1532-1541,共10页
In this paper, we show that sweet quaternary ammonium, pyridinium, and imidazolium cyclamates are cheap, thermally stable, surface and biologically active ionic liquids, with potential application as feeding deterrents.
关键词 ionic liquids cyclamates DETERRENTS biological activity
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