综述具有生物相关性的溶出度方法,以通过理想的体外溶出试验预测体内药动学过程。近年来,研究表明在生物相关性溶出介质中选择合适的溶出装置进行溶出试验得到的溶出曲线能较好地反映其在体内的溶出行为,计算机模拟软件可为建立合理的...综述具有生物相关性的溶出度方法,以通过理想的体外溶出试验预测体内药动学过程。近年来,研究表明在生物相关性溶出介质中选择合适的溶出装置进行溶出试验得到的溶出曲线能较好地反映其在体内的溶出行为,计算机模拟软件可为建立合理的体外溶出度方法提供指导和依据。通过采用合适的生物相关性溶出介质、溶出装置,结合计算机模拟软件可建立A级水平的体内外相关性(in vitro-in vivo correlation,IVIVC),可能代替生物等效性研究。展开更多
流行病学资料显示癌症的发生与糖尿病、某些糖尿病危险因子以及糖尿病治疗之间存在一定的相关性,但是仍有许多的问题需要进一步研究和证实。2010年6月发表在《临床医师肿瘤杂志》(CA Cancer J Clin)上的一篇关于糖尿病和肿瘤的文章让我...流行病学资料显示癌症的发生与糖尿病、某些糖尿病危险因子以及糖尿病治疗之间存在一定的相关性,但是仍有许多的问题需要进一步研究和证实。2010年6月发表在《临床医师肿瘤杂志》(CA Cancer J Clin)上的一篇关于糖尿病和肿瘤的文章让我们受益匪浅,同时我们也针对糖尿病和癌症风险之间可能存在的生物学联系提出了自己的看法,希望对科研工作者有所帮助和启迪。展开更多
This paper reports on two years of measurement of soil respiration and canopy-root biomass in a Leymus chinensis community in the Xilin River basin of Inner Mongolia. Correlations between components of plant biomass a...This paper reports on two years of measurement of soil respiration and canopy-root biomass in a Leymus chinensis community in the Xilin River basin of Inner Mongolia. Correlations between components of plant biomass and soil respiration rates were examined. From respiration data based on CO2 uptake by NaOH and corresponding root biomass values for each run of 10 plots, a linear regression of CO2 evolution rates on root dry weights has been achieved for every ten days. By applying the approach of extrapolating the regressive line to zero root biomass, the proportion of the total soil respiration flux that is attributable to live root respiration was estimated to be about 27% on average, ranging from 14% to 39% in the growing season in 1998. There were no evident relations between the total canopy biomass or root biomass and CO2 evolution rates, but a significant exponential relation did exist between tire live-canopy biomass and CO2 evolution rates.展开更多
The growth characteristics of petroleum-degrader BS-8（Bacillus sp.） and the factors influencing its biosurfactant production were tested; the biosurfactant releasing mode of BS-8 was speculated by measuring OD600, s...The growth characteristics of petroleum-degrader BS-8（Bacillus sp.） and the factors influencing its biosurfactant production were tested; the biosurfactant releasing mode of BS-8 was speculated by measuring OD600, surface tension and oil displacement of fermentation broth; and the effects of carbon source, nitrogen source, temperature, p H, and Na Cl concentration on biosurfactant production by BS-8 were observed in this study. The results showed that the biosurfactant releasing mode of BS-8 was growth-correlated, the surface tension of BS-8 fermentation broth declined with the total bacteria increasing, and the oil displacement was positive correlated with biosurfactant content in fermentation broth; and the optimal culture conditions for effective biosurfactant production included： glucose as carbon source,yeast extract as nitrogen source, Na Cl concentration of 2%, p H of 7.0 and temperature at 30 ℃.展开更多
文摘综述具有生物相关性的溶出度方法,以通过理想的体外溶出试验预测体内药动学过程。近年来,研究表明在生物相关性溶出介质中选择合适的溶出装置进行溶出试验得到的溶出曲线能较好地反映其在体内的溶出行为,计算机模拟软件可为建立合理的体外溶出度方法提供指导和依据。通过采用合适的生物相关性溶出介质、溶出装置,结合计算机模拟软件可建立A级水平的体内外相关性(in vitro-in vivo correlation,IVIVC),可能代替生物等效性研究。
文摘流行病学资料显示癌症的发生与糖尿病、某些糖尿病危险因子以及糖尿病治疗之间存在一定的相关性,但是仍有许多的问题需要进一步研究和证实。2010年6月发表在《临床医师肿瘤杂志》(CA Cancer J Clin)上的一篇关于糖尿病和肿瘤的文章让我们受益匪浅,同时我们也针对糖尿病和癌症风险之间可能存在的生物学联系提出了自己的看法,希望对科研工作者有所帮助和启迪。
文摘This paper reports on two years of measurement of soil respiration and canopy-root biomass in a Leymus chinensis community in the Xilin River basin of Inner Mongolia. Correlations between components of plant biomass and soil respiration rates were examined. From respiration data based on CO2 uptake by NaOH and corresponding root biomass values for each run of 10 plots, a linear regression of CO2 evolution rates on root dry weights has been achieved for every ten days. By applying the approach of extrapolating the regressive line to zero root biomass, the proportion of the total soil respiration flux that is attributable to live root respiration was estimated to be about 27% on average, ranging from 14% to 39% in the growing season in 1998. There were no evident relations between the total canopy biomass or root biomass and CO2 evolution rates, but a significant exponential relation did exist between tire live-canopy biomass and CO2 evolution rates.
基金Supported by Basic and Cutting-edge Technique Research of Henan Province(152300410092)Key Program in Science and Technology of Education Department of Henan Province(15A210020,15B180002,15B180016)~~
文摘The growth characteristics of petroleum-degrader BS-8（Bacillus sp.） and the factors influencing its biosurfactant production were tested; the biosurfactant releasing mode of BS-8 was speculated by measuring OD600, surface tension and oil displacement of fermentation broth; and the effects of carbon source, nitrogen source, temperature, p H, and Na Cl concentration on biosurfactant production by BS-8 were observed in this study. The results showed that the biosurfactant releasing mode of BS-8 was growth-correlated, the surface tension of BS-8 fermentation broth declined with the total bacteria increasing, and the oil displacement was positive correlated with biosurfactant content in fermentation broth; and the optimal culture conditions for effective biosurfactant production included： glucose as carbon source,yeast extract as nitrogen source, Na Cl concentration of 2%, p H of 7.0 and temperature at 30 ℃.
