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神经退化性疾病生物能量代谢和氧化应激研究进展 被引量:18
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作者 张铭湘 夏家辉 《生命科学研究》 CAS CSCD 2000年第4期295-301,共7页
衰老是导致几种常见的神经系统退化性疾病的主要危险因素 ,包括帕金森氏病(Parkinson's disease PD) ,肌萎缩性侧索硬化 (Amyotrophic lateral sclerosis,ALS) ,早老性痴呆 (Alzheimer's disease AD)和亨廷顿氏病 (Huntington&#... 衰老是导致几种常见的神经系统退化性疾病的主要危险因素 ,包括帕金森氏病(Parkinson's disease PD) ,肌萎缩性侧索硬化 (Amyotrophic lateral sclerosis,ALS) ,早老性痴呆 (Alzheimer's disease AD)和亨廷顿氏病 (Huntington's disease HD) .最近研究表明 ,神经退化性疾病涉及到线粒体缺陷 ,氧化应激等因素 .在脑和其它组织中 ,老化可导致线粒体功能的损伤和氧化损伤的增强 .PD病人中 ,已发现线粒体复合酶体 I活性降低 ,氧化损伤增加和抗氧化系统活性的改变 .在几例家族性 ALS病人中 ,也发现 Cu、Zn超氧化物歧化酶 (Cu,ZnSOD)基因的突变 ,导致 Cu、Zn超氧化物歧化酶活性减低 ;散发的 ALS病人氧化损伤增高 .在 HD病人中已发现能量代谢异常和皮质乳酸水平的增高 .AD病人中 ,线粒体复合酶体 IV活性降低 ,AD、PD病人发现有线粒体 DNA突变 .因此 ,渐进性神经退化性疾病很可能由于能量代谢和氧化应激循环过程受损而导致 . 展开更多
关键词 神经退化性疾病 生物能量代谢 氧化应激
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慢性心力衰竭与心肌生物能量代谢 被引量:6
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作者 范晓霞 柳茵 +2 位作者 刘维军 李琳 李俊青 《现代医药卫生》 2011年第5期713-714,共2页
慢性心力衰竭(CHF)是各种心脏疾患的终末状态。大量研究发现,正常心肌和心力衰竭(HF)心肌的能量代谢的特点有所不同,研究发现调节心肌能量代谢有望成为治疗心衰的一种新策略。本文对正常心肌的能量代谢,心衰时能量代谢的变化、能量... 慢性心力衰竭(CHF)是各种心脏疾患的终末状态。大量研究发现,正常心肌和心力衰竭(HF)心肌的能量代谢的特点有所不同,研究发现调节心肌能量代谢有望成为治疗心衰的一种新策略。本文对正常心肌的能量代谢,心衰时能量代谢的变化、能量调节,心衰的评估以及临床应用的相关进展做一综述。 展开更多
关键词 生物能量代谢 慢性心力衰竭 正常心肌 调节心肌能量代谢 心脏疾患 能量调节 临床应用 心衰
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生物能量分析仪在肿瘤细胞生物能量代谢中的应用研究 被引量:6
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作者 汪春龙 郭苗苗 +10 位作者 吴艺琦 陈福红 蓝林华 徐翠翠 楼康诚 沈恺 徐浩 余晓敏 刘永章 吕斌 谢红莉 《中国细胞生物学学报》 CAS CSCD 2016年第9期1066-1076,共11页
靶向肿瘤细胞代谢过程中关键调控分子抑制肿瘤细胞生长的研究日益成为热点。目前,研究肿瘤细胞氧化磷酸化和有氧糖酵解主要是应用Clark氧电极法测定细胞氧耗率以及对相关中间代谢物的测定,如乳酸和葡萄糖。但是,这些方法测定的指标相对... 靶向肿瘤细胞代谢过程中关键调控分子抑制肿瘤细胞生长的研究日益成为热点。目前,研究肿瘤细胞氧化磷酸化和有氧糖酵解主要是应用Clark氧电极法测定细胞氧耗率以及对相关中间代谢物的测定,如乳酸和葡萄糖。但是,这些方法测定的指标相对单一,而且过程繁琐。该文详细介绍了生物能量分析仪在研究肿瘤细胞糖酵解和线粒体氧耗率中的应用,并通过研究肿瘤细胞应用阿霉素及相关药物处理后生物能量代谢的变化,深入探讨了这一方法在研究肿瘤细胞生物能量代谢方面中的优越性。研究结果表明,羰基氰–对–三氟甲氧基本腙(carbonylcyanide p-trifluoro methoxyphenylhydrazone,FCCP)的浓度以及细胞数量对于研究肿瘤细胞的氧耗率十分关键,应用阿霉素能够显著抑制肿瘤细胞的有氧糖酵解和线粒体氧耗率。通过该文的介绍,期望能为肿瘤细胞生物能量代谢研究提供进一步的参考。 展开更多
关键词 氧耗率 有氧糖酵解 胞外产酸率 生物能量代谢
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Variation in energy metabolism structure of microbial community during bioleaching chalcopyrites with different iron-sulfur ratios 被引量:1
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作者 YANG Yu ZHU Zhen-yu +2 位作者 HU Ting-ting ZHANG Meng-jun QIU Guan-zhou 《Journal of Central South University》 SCIE EI CAS CSCD 2021年第7期2022-2036,共15页
The energy metabolism structure of microbial community plays an important role in the process of biohydrometallurgy.In this article,an artificial microbial community composed of three strains(Acidithiobacillus ferroox... The energy metabolism structure of microbial community plays an important role in the process of biohydrometallurgy.In this article,an artificial microbial community composed of three strains(Acidithiobacillus ferrooxidans,Leptospirillum ferriphilum and Acidithiobacillus thiooxidans)was used to leach three kinds of chalcopyrites with different iron-sulfur ratios.After 36 d of leaching,the chalcopyrite with iron-sulfur ratio of about 1:1 achieved the highest copper extraction(69.62%).In the early stage,iron oxidizing bacteria predominated,and the expression of rus and rio was 8 times higher than that in the late stage.In the late stage,sulfur oxidizing bacteria predominated,and the expression of tetH and HdrAB was 4 times higher than that in the early stage.Furthermore,the three bioleaching systems above were added with elemental sulfur(3 g/L);the chalcopyrite with iron-sulfur ratio of about 2:1 achieved the highest copper extraction(80.63%).The results suggest that the energy metabolism structure of the microbial community could be changed by changing the iron-sulfur ratio during the leaching process for improving the leaching efficiency of chalcopyrite. 展开更多
关键词 energy metabolism structure microbial community BIOLEACHING chalcopyrite iron-sulfur ratio
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Proteome Profiles of Longissimus and Biceps Femoris Porcine Muscles Related to Exercise and Resting
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作者 Marinus F.W. Te Pas Els Keuning +3 位作者 Dick J.M. Van De Wiel Jette F. Young Niels Oksbjerg Leo Kruijt 《Journal of Life Sciences》 2011年第8期598-608,共11页
Exercise affects muscle metabolism and composition in the untrained muscles. The proteome of muscle tissue will be affected by exercise and resting. This is of economic importance for pork quality where transportation... Exercise affects muscle metabolism and composition in the untrained muscles. The proteome of muscle tissue will be affected by exercise and resting. This is of economic importance for pork quality where transportation relates to exercise of untrained muscles. Rest reverses exercise effects. The objective of this research was to develop potential protein biomarkers that predict the optimal resting time after exercise related to optimal pork quality. Ten litters of four female pigs were within litter allocated to the four treatment groups: exercise by running on a treadmill for 27 minutes followed by rest for 0, 1, or 3 h; control pigs without exercise. Proteome profiles and biochemical traits measuring energy metabolism and meat quality traits expected to be related to exercise were determined in the Longissimus and the Biceps femoris of the pigs. The results indicated associations between protein abundances in muscles and exercise, resting, and biochemical traits. 展开更多
关键词 EXERCISE muscle tissue proteomics profiles Sus scrofa biochemical energy metabolism meat quality traits rest.
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神经保护剂—纳洛酮
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《中华医学信息导报》 2002年第15期16-16,共1页
纳洛酮可以通过竞争性拮抗内源性阿片肽受体,抑制花生四烯酸代谢,促进SOD生成,阻止脂质过氧化,提高Na-K-ATP酶活性,抑制Ca^2+内流,使各种病理损害的最后通路阻断,因此被称为神经保护剂。
关键词 纳洛酮 神经保护剂 生物能量代谢 神经细胞 自由基
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Energy metabolism of T-lymphocytes and its biological significance
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作者 杨祎 冯娟 +1 位作者 吕思霖 王宪 《Science Bulletin》 SCIE EI CAS CSCD 2016年第16期1270-1280,共11页
Energy homeostasis is essential for maintaining cell survival and regular functions, and the loss of energy homeostasis may result in a variety of diseases. In this review, we focus on the roles and regulatory mechani... Energy homeostasis is essential for maintaining cell survival and regular functions, and the loss of energy homeostasis may result in a variety of diseases. In this review, we focus on the roles and regulatory mechanisms of T lymphocytes energy metabolism in its activation, differentiation and physiological function. We also discuss the significance of T cell energy metabolism for the treatment of inflammatory diseases. 展开更多
关键词 T lymphocyte Energy metabolism Regulatory mechanism Inflammatory disease
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