目的:应用计算机系统生物学方法预测茵陈蒿汤的分子靶标,并阐明有效成分群的协同作用机制。方法:采用TCMGeneDIT数据库系统,文本挖掘茵陈蒿、大黄、栀子各自所能影响的基因或蛋白质数据;收集茵陈蒿汤中6,7-二甲基氧香豆素、京尼平苷、...目的:应用计算机系统生物学方法预测茵陈蒿汤的分子靶标,并阐明有效成分群的协同作用机制。方法:采用TCMGeneDIT数据库系统,文本挖掘茵陈蒿、大黄、栀子各自所能影响的基因或蛋白质数据;收集茵陈蒿汤中6,7-二甲基氧香豆素、京尼平苷、红花黄色素A、大黄酸、大黄素等17种血中移行成分,采用Accelrys公司Discovery Studio 2.5版完成分子构建,并上载至PharmMapper服务器进行靶标预测;从BIND、BioGRID、DIP、HPRD、IntAct、MINT等分子相互作用数据库中收集与预测靶标有直接相互作用的蛋白质,进行综合分析。结果:已有的实验证实:4个蛋白质与茵陈蒿汤相关,8个蛋白质与大黄相关,没有蛋白质与栀子相关。大黄酸、大黄素、6,7-二甲基氧香豆素、绿原酸等6种化学成分不但可直接作用于实验证实的靶标,也可像异秦皮啶、檞皮素3-O-葡萄糖苷等8种化学成分一样,通过影响相关靶标而发挥间接的治疗作用。结论:本研究结果可为茵陈蒿汤的后续研究提供有用的线索,促进茵陈蒿汤的分子作用机制研究,本研究策略可为中药复方的系统研究提供参考。展开更多
目的:应用计算机系统生物学方法预测生脉散的分子靶标,并为生脉散的分子机制提供线索。方法:采用TCMGeneDIT数据库系统,文本挖掘人参、麦冬、五味子各自所能影响的基因或蛋白质数据;收集生脉散中五味子醇甲、五味子醇乙、戈米辛D、五味...目的:应用计算机系统生物学方法预测生脉散的分子靶标,并为生脉散的分子机制提供线索。方法:采用TCMGeneDIT数据库系统,文本挖掘人参、麦冬、五味子各自所能影响的基因或蛋白质数据;收集生脉散中五味子醇甲、五味子醇乙、戈米辛D、五味子乙素、γ-五味子素、20(S)-人参皂苷Rh、人参皂苷Rk3等14种血中移行成分,采用Accelrys公司Discovery Studio 2.5版完成分子构建,并上载至PharmMapper服务器进行靶标预测;从BIND,BioGRID,DIP,HPRD,IntAct,MINT等分子相互作用数据库中收集与预测靶标有直接相互作用的蛋白质,进行综合分析。结果:已有的实验发现,五味子有10个血中移行成分,人参只有4个血中移行成分;人参与55个基因相关,五味子与1个基因相关,没有基因与麦冬相关。人参的4种血中移行成分不但可直接作用于实验证实的靶标,还能影响相关靶标发挥广泛的生物学效应。五味子的10种血中移行成分只能通过影响相关靶标而发挥间接的治疗作用。结论:结果可为生脉散的后续研究提供有用的线索,促进生脉散的分子作用机制研究,为中药复方的系统研究提供参考。展开更多
Based on the biological immune concept, immune response mechanism and expert system, a dynamic and intelligent scheduling model toward the disturbance of the production such as machine fault,task insert and cancel etc...Based on the biological immune concept, immune response mechanism and expert system, a dynamic and intelligent scheduling model toward the disturbance of the production such as machine fault,task insert and cancel etc. Is proposed. The antibody generation method based on the sequence constraints and the coding rule of antibody for the machining procedure is also presented. Using the heuristic antibody generation method based on the physiology immune mechanism, the validity of the scheduling optimization is improved, and based on the immune and expert system under the event-driven constraints, not only Job-shop scheduling problem with multi-objective can be solved, but also the disturbance of the production be handled rapidly. A case of the job-shop scheduling is studied and dynamic optimal solutions with multi-objective function for agile manufacturing are obtained in this paper. And the event-driven dynamic rescheduling result is compared with right-shift rescheduling and total rescheduling.展开更多
Although Yin-Yang Wu-Xing （Yin-Yang and Five-Elements, subsystems of human body） has been the theoretical basis of traditional Chinese medicine （TCM） for more than 5 000 years, it has been primarily analytical or ...Although Yin-Yang Wu-Xing （Yin-Yang and Five-Elements, subsystems of human body） has been the theoretical basis of traditional Chinese medicine （TCM） for more than 5 000 years, it has been primarily analytical or empirical in nature without a formal scientific foundation. Based on bipolar set theory, an equilibrium/non-equilibrium computational model of Yin-Yang Wu-Xing is proposed. The Yin-Yang Wu-Xing dynamical systems are formulated so that equilibrium and non-equilibrium conditions can be established and proved. Computer simulations of equilibrium and non-equilibrium processes show that this new approach can provide diagnostic decision support in TCM. Thus, this equilibrium-based approach provides a unique scientific basis for future research in TCM, Qi （vital energy）, QiGong, Meridians and Collaterals （acupuncture channels） and herbal treatment. On the other hand, it provides a basic Yin-Yang cellular network architecture for modem scientific research in genomics such that regulation mechanisms of the ubiquitous YY1 protein for cell processes can be explained.展开更多
文摘目的:应用计算机系统生物学方法预测茵陈蒿汤的分子靶标,并阐明有效成分群的协同作用机制。方法:采用TCMGeneDIT数据库系统,文本挖掘茵陈蒿、大黄、栀子各自所能影响的基因或蛋白质数据;收集茵陈蒿汤中6,7-二甲基氧香豆素、京尼平苷、红花黄色素A、大黄酸、大黄素等17种血中移行成分,采用Accelrys公司Discovery Studio 2.5版完成分子构建,并上载至PharmMapper服务器进行靶标预测;从BIND、BioGRID、DIP、HPRD、IntAct、MINT等分子相互作用数据库中收集与预测靶标有直接相互作用的蛋白质,进行综合分析。结果:已有的实验证实:4个蛋白质与茵陈蒿汤相关,8个蛋白质与大黄相关,没有蛋白质与栀子相关。大黄酸、大黄素、6,7-二甲基氧香豆素、绿原酸等6种化学成分不但可直接作用于实验证实的靶标,也可像异秦皮啶、檞皮素3-O-葡萄糖苷等8种化学成分一样,通过影响相关靶标而发挥间接的治疗作用。结论:本研究结果可为茵陈蒿汤的后续研究提供有用的线索,促进茵陈蒿汤的分子作用机制研究,本研究策略可为中药复方的系统研究提供参考。
文摘目的:应用计算机系统生物学方法预测生脉散的分子靶标,并为生脉散的分子机制提供线索。方法:采用TCMGeneDIT数据库系统,文本挖掘人参、麦冬、五味子各自所能影响的基因或蛋白质数据;收集生脉散中五味子醇甲、五味子醇乙、戈米辛D、五味子乙素、γ-五味子素、20(S)-人参皂苷Rh、人参皂苷Rk3等14种血中移行成分,采用Accelrys公司Discovery Studio 2.5版完成分子构建,并上载至PharmMapper服务器进行靶标预测;从BIND,BioGRID,DIP,HPRD,IntAct,MINT等分子相互作用数据库中收集与预测靶标有直接相互作用的蛋白质,进行综合分析。结果:已有的实验发现,五味子有10个血中移行成分,人参只有4个血中移行成分;人参与55个基因相关,五味子与1个基因相关,没有基因与麦冬相关。人参的4种血中移行成分不但可直接作用于实验证实的靶标,还能影响相关靶标发挥广泛的生物学效应。五味子的10种血中移行成分只能通过影响相关靶标而发挥间接的治疗作用。结论:结果可为生脉散的后续研究提供有用的线索,促进生脉散的分子作用机制研究,为中药复方的系统研究提供参考。
基金This work was supported by National Science Foundation of Shanghai(02ZF14003)
文摘Based on the biological immune concept, immune response mechanism and expert system, a dynamic and intelligent scheduling model toward the disturbance of the production such as machine fault,task insert and cancel etc. Is proposed. The antibody generation method based on the sequence constraints and the coding rule of antibody for the machining procedure is also presented. Using the heuristic antibody generation method based on the physiology immune mechanism, the validity of the scheduling optimization is improved, and based on the immune and expert system under the event-driven constraints, not only Job-shop scheduling problem with multi-objective can be solved, but also the disturbance of the production be handled rapidly. A case of the job-shop scheduling is studied and dynamic optimal solutions with multi-objective function for agile manufacturing are obtained in this paper. And the event-driven dynamic rescheduling result is compared with right-shift rescheduling and total rescheduling.
文摘Although Yin-Yang Wu-Xing （Yin-Yang and Five-Elements, subsystems of human body） has been the theoretical basis of traditional Chinese medicine （TCM） for more than 5 000 years, it has been primarily analytical or empirical in nature without a formal scientific foundation. Based on bipolar set theory, an equilibrium/non-equilibrium computational model of Yin-Yang Wu-Xing is proposed. The Yin-Yang Wu-Xing dynamical systems are formulated so that equilibrium and non-equilibrium conditions can be established and proved. Computer simulations of equilibrium and non-equilibrium processes show that this new approach can provide diagnostic decision support in TCM. Thus, this equilibrium-based approach provides a unique scientific basis for future research in TCM, Qi （vital energy）, QiGong, Meridians and Collaterals （acupuncture channels） and herbal treatment. On the other hand, it provides a basic Yin-Yang cellular network architecture for modem scientific research in genomics such that regulation mechanisms of the ubiquitous YY1 protein for cell processes can be explained.
