背景:随着医疗技术的发展,恶性骨肿瘤的保肢手术逐步成为主要趋势,因而各种生物重建方法得以在临床中引用。目的:对四肢恶性骨肿瘤骨切除后大段骨缺损的生物重建进行综述。方法:由第一作者应用计算机检索PubMed、Web of science、万方...背景:随着医疗技术的发展,恶性骨肿瘤的保肢手术逐步成为主要趋势,因而各种生物重建方法得以在临床中引用。目的:对四肢恶性骨肿瘤骨切除后大段骨缺损的生物重建进行综述。方法:由第一作者应用计算机检索PubMed、Web of science、万方数据库、中国知网中2000至2020年出版的文献,英文检索词为"malignant bone tumor,bone defect,biological reconstruction,limb salvage",中文检索词为"恶性骨肿瘤,保肢方法,生物重建技术"。查阅近年国内外有关肢体恶性骨肿瘤术后大段骨缺损生物重建的文献并进行综述,剔除与研究主题不符的文献,总结各种生物重建手术方式的优缺点。结果与结论:①针对四肢恶性骨肿瘤骨切除后大段骨缺损,瘤段骨原位灭活、关节缺损后生物重建和节段骨切除后生物重建方法各有利弊,对适应证不同的患者应选择不同手术方法;②提示生物重建可为四肢恶性骨肿瘤保肢治疗提供重要方法。展开更多
The gastrointestinal (GI) tract is the system of organs within multi-cellular animals that takes in food, digests it to extract energy and nutrients, and expels the remaining waste. The various patterns of GI tract fu...The gastrointestinal (GI) tract is the system of organs within multi-cellular animals that takes in food, digests it to extract energy and nutrients, and expels the remaining waste. The various patterns of GI tract function are generated by the integrated behaviour of multiple tissues and cell types. A thorough study of the GI tract requires understanding of the interactions between cells, tissues and gastrointestinal organs in health and disease. This depends on knowledge, not only of numerous cellular ionic current mechanisms and signal transduction pathways, but also of large scale GI tissue structures and the special distribution of the nervous network. A unique way of coping with this explosion in complexity is mathematical and computational modelling; providing a computational framework for the multilevel modelling and simulation of the human gastrointestinal anatomy and physiology. The aim of this review is to describe the current status of biomechanical modelling work of the GI tract in humans and animals, which can be further used to integrate the physiological, anatomical and medical knowledge of the GI system. Such modelling will aid research and ensure that medical professionals benefit, through the provision of relevant and precise information about the patient's condition and GI remodelling in animal disease models. It will also improve the accuracy and efficiency of medical procedures, which could result in reduced cost for diagnosis and treatment.展开更多
A novel technique of three-dimensional (3D) reconstruction, segmentation, display and analysis of series slices of images including microscopic wide field optical sectioning by deconvolution method, cryo-electron micr...A novel technique of three-dimensional (3D) reconstruction, segmentation, display and analysis of series slices of images including microscopic wide field optical sectioning by deconvolution method, cryo-electron microscope slices by Fou-rier-Bessel synthesis and electron tomography (ET), and a series of computed tomography (CT) was developed to perform si-multaneous measurement on the structure and function of biomedical samples. The paper presents the 3D reconstruction seg-mentation display and analysis results of pollen spore, chaperonin, virus, head, cervical bone, tibia and carpus. At the same time, it also puts forward some potential applications of the new technique in the biomedical realm.展开更多
Medically, electrical impedance tomography （EIT） is a relatively inexpensive, safe, non-invasive and portable technique compared with computerized tomography （CT） and magnetic resonance imaging （MRI）. In this pa...Medically, electrical impedance tomography （EIT） is a relatively inexpensive, safe, non-invasive and portable technique compared with computerized tomography （CT） and magnetic resonance imaging （MRI）. In this paper, EIT_TJU_ II system is developed including both the data collection system and image reconstruction algo- rithm. The testing approach of the system performance, including spatial resolution and sensitivity, is described through brine tank experiments. The images of the thorax physical model verify that the system can reconstruct the interior resistivity distribution. Finally, the lung ventilation functional monitoring in vivo is realized by EIT, and the visualized images indicate that the configuration and performance of EIT_TJU_ II system are feasible and EIT is a promising technique in clinical monitoring application.展开更多
The paper deals with the Lower Kungurian （Philippovian Horizon; Lower Permian） biota of the Mid-dle Cis-Urals, Russia. The biota is characterized on the basis of four representative localities （ Philippovskoe B...The paper deals with the Lower Kungurian （Philippovian Horizon; Lower Permian） biota of the Mid-dle Cis-Urals, Russia. The biota is characterized on the basis of four representative localities （ Philippovskoe Bus-stop, Philippovskian Quarry, Kamai and Kiselevo-Suksun Highway） , which are situated in the stratotype area of the Kungurian stage. All the localities can be regarded as Lagerstatten, but of authentically low biodi-versity ,since they represent oligotrophic lagoons of abnormal fluctuating salinity. General reconstruction of the Philippovian near-shore shallow-water ecosystem is given. Two new species of algae Algites philippoviensis sp. nov., A. shurtanensis sp. nov., and a new species of the limulids Paleolimulus kunguricus sp. nov. are de-scribed for the first time.展开更多
文摘背景:随着医疗技术的发展,恶性骨肿瘤的保肢手术逐步成为主要趋势,因而各种生物重建方法得以在临床中引用。目的:对四肢恶性骨肿瘤骨切除后大段骨缺损的生物重建进行综述。方法:由第一作者应用计算机检索PubMed、Web of science、万方数据库、中国知网中2000至2020年出版的文献,英文检索词为"malignant bone tumor,bone defect,biological reconstruction,limb salvage",中文检索词为"恶性骨肿瘤,保肢方法,生物重建技术"。查阅近年国内外有关肢体恶性骨肿瘤术后大段骨缺损生物重建的文献并进行综述,剔除与研究主题不符的文献,总结各种生物重建手术方式的优缺点。结果与结论:①针对四肢恶性骨肿瘤骨切除后大段骨缺损,瘤段骨原位灭活、关节缺损后生物重建和节段骨切除后生物重建方法各有利弊,对适应证不同的患者应选择不同手术方法;②提示生物重建可为四肢恶性骨肿瘤保肢治疗提供重要方法。
基金Supported by A grant from US National Institute of Health with No. 1RO1DK072616-01A2Karen Elise Jensen Fond
文摘The gastrointestinal (GI) tract is the system of organs within multi-cellular animals that takes in food, digests it to extract energy and nutrients, and expels the remaining waste. The various patterns of GI tract function are generated by the integrated behaviour of multiple tissues and cell types. A thorough study of the GI tract requires understanding of the interactions between cells, tissues and gastrointestinal organs in health and disease. This depends on knowledge, not only of numerous cellular ionic current mechanisms and signal transduction pathways, but also of large scale GI tissue structures and the special distribution of the nervous network. A unique way of coping with this explosion in complexity is mathematical and computational modelling; providing a computational framework for the multilevel modelling and simulation of the human gastrointestinal anatomy and physiology. The aim of this review is to describe the current status of biomechanical modelling work of the GI tract in humans and animals, which can be further used to integrate the physiological, anatomical and medical knowledge of the GI system. Such modelling will aid research and ensure that medical professionals benefit, through the provision of relevant and precise information about the patient's condition and GI remodelling in animal disease models. It will also improve the accuracy and efficiency of medical procedures, which could result in reduced cost for diagnosis and treatment.
文摘A novel technique of three-dimensional (3D) reconstruction, segmentation, display and analysis of series slices of images including microscopic wide field optical sectioning by deconvolution method, cryo-electron microscope slices by Fou-rier-Bessel synthesis and electron tomography (ET), and a series of computed tomography (CT) was developed to perform si-multaneous measurement on the structure and function of biomedical samples. The paper presents the 3D reconstruction seg-mentation display and analysis results of pollen spore, chaperonin, virus, head, cervical bone, tibia and carpus. At the same time, it also puts forward some potential applications of the new technique in the biomedical realm.
基金Supported by National Natural Science Foundation of China (No.60820106002, No.60532020)Tianjin Natural Science Foundation (No.08JCYBJC03500).
文摘Medically, electrical impedance tomography （EIT） is a relatively inexpensive, safe, non-invasive and portable technique compared with computerized tomography （CT） and magnetic resonance imaging （MRI）. In this paper, EIT_TJU_ II system is developed including both the data collection system and image reconstruction algo- rithm. The testing approach of the system performance, including spatial resolution and sensitivity, is described through brine tank experiments. The images of the thorax physical model verify that the system can reconstruct the interior resistivity distribution. Finally, the lung ventilation functional monitoring in vivo is realized by EIT, and the visualized images indicate that the configuration and performance of EIT_TJU_ II system are feasible and EIT is a promising technique in clinical monitoring application.
基金supported by the State Program for Supporting Competitive Growth of the Kazan Fe-deral University among World's Leading Scientific-Educational Centers and the Russian Foundation for Basic Research
文摘The paper deals with the Lower Kungurian （Philippovian Horizon; Lower Permian） biota of the Mid-dle Cis-Urals, Russia. The biota is characterized on the basis of four representative localities （ Philippovskoe Bus-stop, Philippovskian Quarry, Kamai and Kiselevo-Suksun Highway） , which are situated in the stratotype area of the Kungurian stage. All the localities can be regarded as Lagerstatten, but of authentically low biodi-versity ,since they represent oligotrophic lagoons of abnormal fluctuating salinity. General reconstruction of the Philippovian near-shore shallow-water ecosystem is given. Two new species of algae Algites philippoviensis sp. nov., A. shurtanensis sp. nov., and a new species of the limulids Paleolimulus kunguricus sp. nov. are de-scribed for the first time.
