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民众生理需求与太平天国——太平天国民众心理需求动因研究之一
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作者 廖胜 《绵阳师范学院学报》 1999年第6期66-70,共5页
太平天国是一次史无前例的伟大的农民运动.转战18省,横扫千军如卷席,但仅历时十四年便退出了历史舞台;曾经赢得数百万人信仰的“拜上帝教”,最终也消失得无影无踪.荣辱兴枯.发人深省.对其兴亡的原因,史家学者从阶级根源、民族根源、思... 太平天国是一次史无前例的伟大的农民运动.转战18省,横扫千军如卷席,但仅历时十四年便退出了历史舞台;曾经赢得数百万人信仰的“拜上帝教”,最终也消失得无影无踪.荣辱兴枯.发人深省.对其兴亡的原因,史家学者从阶级根源、民族根源、思想根源乃至灾荒影响等方面作了深入的剖析,但是“战争的伟力之最深厚的根源,存在于民众之中”.要达到动员、依靠民众战胜敌人,就必须“解决群众的穿衣问题,吃饭问题,住房问题,柴米油盐问题,疾病卫生问题,婚姻问题.总之,一切群众的实际生活问题…….假如我们对这些问题注意了,解决了,满足了群众的需要,我们就真正成了群众生活的组织者,群众就会围绕在我们的周围、热烈地拥护我们.很显然,在讨论太平天国兴亡的原因和经验教训时,不容忽视的一个根本问题就是民众需求的问题.事实上,满足民众需求与否直接成为太平天国兴亡的最重要的动因.按照心理学需要理论,笔者拟从民众生理需求、民众安全需求、民众归属与相爱需求三个专题进行逐一探讨.本文从民众生理需求动因与太平天国兴亡的关系作一初步论述,不当之处,敬请史学同仁批评教正! 展开更多
关键词 民众 生理需求动因 太平天国 兴亡
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大学生恋爱问题简析 被引量:1
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作者 程万寿 《洛阳师专学报(自然科学版)》 1997年第1期118-120,共3页
关键词 中国 高校 学生 恋爱心理 教育动因 思想教育 校园文化建设 心理健康教育 生理动因
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GFAP promoter directs lacZ expression specifically in a rat hepatic stellate cell line 被引量:4
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作者 Gunter Maubach Michelle Chin Chia Lim 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第5期723-730,共8页
AIM: The GFAP was traditionally considered to be a biomarker for neural gila (mainly astrocytes and nonmyelinating Schwann cells). Genetically, a 2.2-kb human GFAP promoter has been successfully used to target astr... AIM: The GFAP was traditionally considered to be a biomarker for neural gila (mainly astrocytes and nonmyelinating Schwann cells). Genetically, a 2.2-kb human GFAP promoter has been successfully used to target astrocytes in vitro and in vivo. More recently, GFAP was also established as one of the several makers for identifying hepatic stellate cells (HSC). In this project, possible application of the same 2.2-kb human GFAP promoter for targeting HSC was investigated. METHODS: The GFAP-lacZ transgene was transfected into various cell lines (HSC, hepatocyte, and other nonHSC cell types). The transgene expression specificity was determined by X-gal staining of the β-galactosidase activity. And the responsiveness of the transgene was tested with a typical pro-fibrotic cytokine TGF-β1. The expression of endogenous GFAP gene was assessed by real-time RT-PCR, providing a reference for the transgene expression. RESULTS: The results demonstrated for the first time that the 2.2 kb hGFAP promoter was not only capable of directing HSC-specific expression, but also responding to a known pro-fibrogenic cytokine TGF-β1 by upregulation in a doseand time-dependent manner, similar to the endogenous GFAP. CONCLUSION: In conclusion, these findings suggested novel utilities for using the GFAP promoter to specifically manipulate HSC for therapeutic purpose. 展开更多
关键词 Promoter Regions (Genetics) Animals Base Sequence Cell Line DNA Recombinant Gene Expression Glial Fibrillary Acidic Protein HEPATOCYTES Humans Lac Operon RNA Messenger Rats TRANSFECTION Transforming Growth Factor beta Transforming Growth Factor beta1
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Social rank and cortisol among female rhesus macaques (Macaca mulatta)
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作者 Dong-Dong QIN Joshua Dominic Rizak +6 位作者 Xiao-Li FENG Xun-Xun CHU Shang-Chuan YANG Chun-Lu LI Long-Bao LV Yuan-Ye MA Xin-Tian HU 《Zoological Research》 CAS CSCD 北大核心 2013年第2期J0008-J0015,共8页
In animal societies, some stressful events can lead to higher levels of physiological stress. Such stressors, like social rank, also predict an increased vulnerability to an array of diseases. However, the physiologic... In animal societies, some stressful events can lead to higher levels of physiological stress. Such stressors, like social rank, also predict an increased vulnerability to an array of diseases. However, the physiological relationship between social rank and stress varies between different species, as well as within groups of a single species. For example, dominant individuals are more socially stressed at times, while at other times it is the subordinate ones who experience this stress. Together, these variations make it difficult to assess disease vulnerability as connected to social interactions. In order to learn more about how physiological rank relationships vary between groups of a single species, cortisol measurements from hair samples were used to evaluate the effects of dominance rank on long-term stress levels in despotic and less stringent female rhesus macaque hierarchal groups. In despotic groups, cortisol levels were found not to be correlated with social rank, but a negative correlation was found between social rank and cortisol levels in less stringent hierarchies. Low ranking monkeys in less stringent groups secreted elevated levels of cortisol compared to higher ranking animals. These data suggest that variations in the strictness of the dominance hierarchy are determining factors in rank related stress physiology. The further consideration of nonhuman primate social system diversity and the linear degree of their hierarchies may allow for the development of valid rank-related stress models that will help increase our understanding and guide the development of new therapeutics for diseases related to human socioeconomic status. 展开更多
关键词 Social rank Hypothalamus-pituitary-adrenal axis CORTISOL FEMALE Rhesus macaques
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Changes in Ecosystem Service of Soil Conservation Between 2000 and 2010 and Its Driving Factors in Southwestern China 被引量:17
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作者 RAO Enming XIAO Yi +1 位作者 OUYANG Zhiyun ZHENG Hua 《Chinese Geographical Science》 SCIE CSCD 2016年第2期165-173,共9页
Human activities significantly alter ecosystems and their services; however, quantifying the impact of human activities on ecosystems has been a great challenge in ecosystem management. We used the Universal Soil Loss... Human activities significantly alter ecosystems and their services; however, quantifying the impact of human activities on ecosystems has been a great challenge in ecosystem management. We used the Universal Soil Loss Equation and county-level socioeconomic data to assess the changes in the ecosystem service of soil conservation between 2000 and 2010, and to analyze its spatial characteristics and driving factors in the southwestern China. The results showed that cropland in the southwestern China decreased by 3.74%, while urban land, forest, and grassland areas increased by 46.78%, 0.86%, and 1.12%, respectively. The soil conservation increased by 1.88 × 10^(11) kg, with deterioration only in some local areas. The improved and the degraded areas accounted for 6.41% and 2.44% of the total land area, respectively. Implementation of the Sloping Land Conversion Program and urbanization explained 57.80% and 23.90% of the variation in the soil conservation change, respectively, and were found to be the main factors enhancing soil conservation. The 2008 Wenchuan earthquake was one of the factors that led to the degradation of soil conservation. Furthermore, industrial adjustment, by increasing shares of Industry and Service and reducing those of Agriculture, has also promoted soil conservation. Our results quantitatively showed and emphasized the contributions to soil conservation improvement made by implementing ecological restoration programs and promoting urbanization. Consequently, these results provide basic information to improve our understanding of the effects of ecological restoration programs, and help guide future sustainable urban development and regional industrial restructuring. 展开更多
关键词 soil conservation ecosystem service Sloping Land Conversion Program(SLCP) ecological restoration urbanization southwestern China
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EFFECT OF SOMATOSTATIN ON THE EXPRESSION OF TNF α mRNA IN MULTIORGANS OF RATS WITH ACUTE HEMORRHAGIC NECROTIC PANCREATITIS
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作者 秦仁义 肖雪明 +2 位作者 邹声泉 吴在德 裘法祖 《Chinese Medical Sciences Journal》 CAS CSCD 1998年第3期134-137,共4页
Objectives.To study the expression of TNF α mRNA and the effect of somatostatin on the expression of TNF α mRNA in multiorgans of rats with acute hemorrhagic necrotic pancreatitis(AHNP). Methods.AHNP in the rat was ... Objectives.To study the expression of TNF α mRNA and the effect of somatostatin on the expression of TNF α mRNA in multiorgans of rats with acute hemorrhagic necrotic pancreatitis(AHNP). Methods.AHNP in the rat was induced by retrograde injection of 5% sodium taurocholate into the bile-pancreatic duct. Somatostatin octapeptide (SS-OP) (2μg/kg)was injected into the femoral vein imme- diately in rats of the treatment group after inductive AHNP. Rats of the sham operative group received in- jection of saline. Sixty animals of the AHNP and sham operative groups at the designated time(0. 2h, 0. 5 h, 2h, 4h, 8h, after the operation,six animals at each time point)and tweleve animals of treatment group at 4h after the operation were sacrificed for samples of pancreas, liver and lung. The expressions of TNF α mRNA within the pancreas, liver and lung were established by RT-PCR. Results. TNF α mRNA became detectable in the pancreas as early as 0. 2h after inductive AHNP, while it was undetectable in other organs until 0. 5h. Expression of TNF α mRNA in each tissue increased continuously and reached a peak at 4h,demonstrating a significant difference compared with that at 0. 5h and 8h. Expressions of TNF α mRNA from pancreas, liver and lung were decreased 50-80% in the treat- ment group, the pancreatic necrosis was also attenuated dramatically. Conclusion. TNF α mRNA was detectable in pancreas,liver and lung tissues at the early stage of AH- NP.SS-OP can significantly inhibit the expression of TNF α mRNA and attenuate the pancreatic necrosis. We feel that this may be an important mechanism of SS-OP in the treatment of AHNP. 展开更多
关键词 acute hemorrhagic necrotic pancreatitis somatostatin-octapeptide TNF α mR- NA gene expression
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MacroH2A1.1 cooperates with EZH2 to promote adipogenesis by regulating Wnt signaling 被引量:3
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作者 Danyang Wan Chengyu Liu +3 位作者 Yu Sun Wenjun Wang Kun Huang Ling Zheng 《Journal of Molecular Cell Biology》 SCIE CAS CSCD 2017年第4期325-337,共13页
White adipocytes play important roles in many physiological processes, including energy storage, endocrine signaling, and inflammatory responses. Understanding the molecular mechanisms of adipocyte formation (adipoge... White adipocytes play important roles in many physiological processes, including energy storage, endocrine signaling, and inflammatory responses. Understanding the molecular mechanisms of adipocyte formation (adipogenesis) provides insights into therapeutic approaches against obesity and its related diseases. Many transcriptional Factors and epigenetic enzymes are known to regulate adipogenesis; however, whether histone variants play a role in this process is unknown. Here we found that macroH2A1.1 (mH2A1.1), a variant of histone H2A, was upregulated during adipocyte differentiation in 3T3-L1 ceils and in the white adipose tissue of obese mice. Ablation of mH2A1.1 activated Wnt/β-catenin signaling pathway, while overexpression of mH2A1.1 showed opposite effects. We farther found that mH2A1.1 regulated Wnt/β-catenin signaling pathway by cooperating with EZH2, a histone H3K27 methyltrans- ferase, thus led to accumulation of H3K27me2 and H3K27me3 on the promoters of Wnt genes. Mutations in the macro-domain, mH2A1.1G224E, and mH2A1.1G314E, not only impaired adipogenesis, but also impaired the binding ability of mH2A1.1 to EZH2 and the enrichments of H3K27me2 and H3K27me3 on the promoters of Wnt genes. Together, our study reveals a novel regulatory role of mH2A1.1 in adipogenesis and obesity, which provides new insights in white fat development. 展开更多
关键词 ADIPOGENESIS EZH2 H3K27me2/me3 macroH2A1.1 Wnt/β-catenin signaling
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