Activating transcription factor 4 （ATF4） has been shown to play key roles in many physiological processes. There are no reports, however, demonstrating a direct link between ATF4 and lipid metabolism. We noticed tha...Activating transcription factor 4 （ATF4） has been shown to play key roles in many physiological processes. There are no reports, however, demonstrating a direct link between ATF4 and lipid metabolism. We noticed that Atf4- deficient mice are lean, suggesting a possible role for ATF4 in regulating lipid metabolism. The goal of our current study is to investigate the involvement of ATF4 in lipid metabolism and elucidate the underlying mechanisms. Studies using Atf4-deficient mice revealed increased energy expenditure, as measured by oxygen consumption. These mice also showed increases in lipolysis, expression of uncoupling protein 2 （UCP2） and p-oxidation genes and decreases in expression of lipogenic genes in white adipose tissue （WAT）, suggesting increased utilization and decreased synthesis of fatty acids, respectively. Expression of UCP1, 2 and 3 was also increased in brown adipose tissue （BAT）, suggesting increased thermogenesis. The effect of ATF4 deletion on expression of UCPs in BAT suggests that increased thermogenesis may underlie increased energy expenditure. Thus, our study identifies a possible new function for ATF4 in regulating lipid metabolism and thermogenesis.展开更多
To quantify the energy consumption in the process of production, transportation and processing of energy carriers, the life cycle of building energy used can be divided into two phases： on-site phase and embodied pha...To quantify the energy consumption in the process of production, transportation and processing of energy carriers, the life cycle of building energy used can be divided into two phases： on-site phase and embodied phase. As for the embodied phase, with the data in existing statistic yearbook, the consumption items of energy production and transportation were investigated. And based on the life cycle theory, an embodied coefficient of energy carriers was proposed to quantify the embodied energy consumption. Moreover, a calculation method for the embodied coefficient of energy carriers was deduced using Leontief inverse matrix based on the existing data sources. With relevant data of 2005-2007 in China, the embodied coefficients in 2005-2007 were obtained, in which the values for natural gas and thermal power are around 1.3 and 3. l, respectively; while they are 1.03-1.08 for other selected energy carriers. In addition, it is also found that the consumption in the production and processing accounts for more than 75%.展开更多
Taking a sewage treatment project of Dalian for example, this paper studied the feasibility and characteristics of two sewage treatment technologies, analyzed the process, operation management and energy consumption, ...Taking a sewage treatment project of Dalian for example, this paper studied the feasibility and characteristics of two sewage treatment technologies, analyzed the process, operation management and energy consumption, and determined the hydrolytic sedimentation tank - biological filter - V-Filter technology as the final solution of this project.展开更多
Specific dynamic action(SDA), the energy expended on all physiological processes that is associated with meal digestion and absorption, is strongly affected by food type. Effects of formulated diet(FMD), macroalgae(AL...Specific dynamic action(SDA), the energy expended on all physiological processes that is associated with meal digestion and absorption, is strongly affected by food type. Effects of formulated diet(FMD), macroalgae(ALG) and sea mud(SMD) diets on the postprandial metabolic response of the green type and the red type of sea cucumber(Apostichopus japonicus) were studied in order to understand their feeding physiology. Food offered to A. japonicus was different in protein, lipid content and energy but not in meal mass. SDA of A. japonicus resulted in a 1.3–2.7 folds of increase in oxygen consumption that can persist for up to 4.8–31.7 h after digesting three different diets. In a given type of sea cucumber, the magnitude of SDA was the highest when fed with FMD, medium with ALG, and the lowest with SMD, which is probably due to the differences in diet components and protein contents. The red type sea cucumber showed greater SDA magnitude than the green type with each diet treatment, which might result from the difference in factorial scope between the two types of sea cucumber. However, the smallest magnitude or even no difference was observed between the two types of A. japonicus in SMD group, perhaps owing to the poor nutrition and digestion of sea mud.展开更多
文摘Activating transcription factor 4 （ATF4） has been shown to play key roles in many physiological processes. There are no reports, however, demonstrating a direct link between ATF4 and lipid metabolism. We noticed that Atf4- deficient mice are lean, suggesting a possible role for ATF4 in regulating lipid metabolism. The goal of our current study is to investigate the involvement of ATF4 in lipid metabolism and elucidate the underlying mechanisms. Studies using Atf4-deficient mice revealed increased energy expenditure, as measured by oxygen consumption. These mice also showed increases in lipolysis, expression of uncoupling protein 2 （UCP2） and p-oxidation genes and decreases in expression of lipogenic genes in white adipose tissue （WAT）, suggesting increased utilization and decreased synthesis of fatty acids, respectively. Expression of UCP1, 2 and 3 was also increased in brown adipose tissue （BAT）, suggesting increased thermogenesis. The effect of ATF4 deletion on expression of UCPs in BAT suggests that increased thermogenesis may underlie increased energy expenditure. Thus, our study identifies a possible new function for ATF4 in regulating lipid metabolism and thermogenesis.
基金Project(CDJZR10210009) supported by Central College General Fund for Natural Science of Chongqing City,China
文摘To quantify the energy consumption in the process of production, transportation and processing of energy carriers, the life cycle of building energy used can be divided into two phases： on-site phase and embodied phase. As for the embodied phase, with the data in existing statistic yearbook, the consumption items of energy production and transportation were investigated. And based on the life cycle theory, an embodied coefficient of energy carriers was proposed to quantify the embodied energy consumption. Moreover, a calculation method for the embodied coefficient of energy carriers was deduced using Leontief inverse matrix based on the existing data sources. With relevant data of 2005-2007 in China, the embodied coefficients in 2005-2007 were obtained, in which the values for natural gas and thermal power are around 1.3 and 3. l, respectively; while they are 1.03-1.08 for other selected energy carriers. In addition, it is also found that the consumption in the production and processing accounts for more than 75%.
文摘Taking a sewage treatment project of Dalian for example, this paper studied the feasibility and characteristics of two sewage treatment technologies, analyzed the process, operation management and energy consumption, and determined the hydrolytic sedimentation tank - biological filter - V-Filter technology as the final solution of this project.
基金the National Key Technologies Research and Development Program of China (No. 2011BAD13B03)Foundation of Liaoning Educational Committee (No. L2014254)
文摘Specific dynamic action(SDA), the energy expended on all physiological processes that is associated with meal digestion and absorption, is strongly affected by food type. Effects of formulated diet(FMD), macroalgae(ALG) and sea mud(SMD) diets on the postprandial metabolic response of the green type and the red type of sea cucumber(Apostichopus japonicus) were studied in order to understand their feeding physiology. Food offered to A. japonicus was different in protein, lipid content and energy but not in meal mass. SDA of A. japonicus resulted in a 1.3–2.7 folds of increase in oxygen consumption that can persist for up to 4.8–31.7 h after digesting three different diets. In a given type of sea cucumber, the magnitude of SDA was the highest when fed with FMD, medium with ALG, and the lowest with SMD, which is probably due to the differences in diet components and protein contents. The red type sea cucumber showed greater SDA magnitude than the green type with each diet treatment, which might result from the difference in factorial scope between the two types of sea cucumber. However, the smallest magnitude or even no difference was observed between the two types of A. japonicus in SMD group, perhaps owing to the poor nutrition and digestion of sea mud.
