“求平均数”教学设计

教学内容:义务教育六年制小学数学第十册(人教版)第13—14页例1和例2,完成“做一做”和练习三第1—4题.

Advanced pancreatic ductal adenocarcinoma-Complexities of treatment and emerging therapeutic options

Pancreatic ductal adenocarcinoma is a devastating disease with a poor prognosis regardless of stage. To date the mainstay of therapy for advanced disease has been chemotherapy with little incremental im-provements in outcome. Despite extensive research investigating new treatment options the current practices continue to utilise fluorouracil or gemcitabine containing combinations. The need for novel the-rapeutic approaches is mandated by the ongoing poor survival rates associated with this disease. One such approach may include manipulation of ribosome biogenesis and the nucleolar stress response, which has recently been applied to haematological malignancies such as lymphoma and prostate cancer with promising results. This review will focus on the current therapeutic options for pancreatic ductal adenocarcinoma and the complexities associated with developing novel treatments, with a particular emphasis on the role of the nucleolus as a treatment strategy.

An Analysis of the Tragedy in The Catcher in the Rye

Jerome David Salinger is a famous American novelist. His famous novel The Catcher in the Rye, vividly shows us imagination of a teenage after the Second World War. In this novel, the writer put contradiction between American teenager material life and the lack of spiritual life after the World War II, reflected on the protagonist Holden. In the novel, Amanda Louise Holden hated the adult hypocritical world and he wanted to escape from the reality, but his weakness decided that he finally ended in failure and the collapse of the spirit. Holden is a victim of the era and the tragedy of the times. This paper tries to make a detailed and deep analysis on the tragedy of Holden in the novel

用赞美打开心门

你遇到过这种情况吗?心中明明有很多的感受和委屈想说给爱人听,可对方敷衍的神态、带有武断的批评、不容置疑的否定,让你从此闭上嘴巴、关上心门,不想再将伤口和软弱向对方敞开。我也曾因此而把夫妻间沟通不畅的原因都推到男人身上,而这样的想法在一堂心理课上被颠覆了。其实对方的听不进去或不接纳,是因为我说话的时候也一样带有指责和批判,只不过没有发觉罢了。有的"沟通"

TAA family contributes to auxin production during de novo regeneration of adventitious roots from Arabidopsis leaf explants

Many differentiated plant organs have the ability to regenerate into a new plant after detachment via de novo organogenesis. During de novo root organogenesis from Arabidopsis thaliana leaf explants, wounding first induces endogenous auxin production in mesophyll cells. Auxin is then polar transported to, and accumulates in, regenerationcompetent cells near the wound to trigger the cell-fate transition. The TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS(TAA) family proteins and the YUCCA(YUC) family proteins catalyze two successive biochemical steps in auxin biogenesis, and YUCs have been shown to be involved in auxin production in mesophyll cells during de novo root organogenesis. In thisstudy, we show that the TAA family is also required for adventitious rooting. Inhibition of TAA blocked adventitious root formation from leaf explants. Intriguingly,whereas YUC1 and YUC4 have been shown to be highly induced by wounding, TAA genes retained consistent expression levels before and after leaf detachment.Therefore, we suggest that TAAs and YUCs are both required for auxin biogenesis in leaf explants, but they play different roles in regeneration. While YUC1 and YUC4 function in response to wounding to catalyze the ratelimiting step in auxin biosynthesis, TAAs probably serve as abiding and basal enzymes during de novo root organogenesis from leaf explants.

Effects of latitudinal variation on field and common garden comparisons between native and introduced groundsel(Senecio vulgaris)populations

Aims Field and common garden comparisons are commonly performed to test the rapid evolution of increased vigor in introduced plant populations.Latitudinal dines in phenotypic traits can obscure such evolutionary inferences,particularly when native or introduced populations are distributed across large geographic ranges.We tested whether the latitudinal dines influence comparisons between introduced and native populations of Senecio vulgaris.Methods Senecio vulgaris is native to Europe but has been introduced in northeastern and southwestern China.To evaluate the performance in terms of growth and reproduction between native European populations and introduced Chinese populations,we compared plant height,number of branches and number of capitula in field populations in native and introduced ranges and in a common garden in Switzerland.Important Findings The introduced Chinese populations performed better than the native European populations in the field in terms of plant height and number of capitula,which was consistent with the prediction of the evolution of the increased competitive ability(EICA)hypothesis.The Chinese populations produced more capitula than the European populations when the latitudinal cline was considered in the common garden comparison.When we compared the traits of the northeastern Chinese,southwestern Chinese and European populations in both the field and common garden,the northeastern Chinese populations,at latitudes similar to those of the European populations,exhibited greater plant size and more capitula than the European populations in both the field and common garden.However,the southwestern Chinese populations,at latitudes much lower than those of the European populations,did not perform better than the native populations in terms of reproduction.In conclusion,our results suggest that latitudinal dines in phenotypic traits should be considered in field and common garden comparisons when introduced populations are geographically structured.

Interspecific interactions affect N and P uptake rather than N:P ratios of plant species:evidence from intercropping

Quantifying stoichiometry of crop N and P acquisition(i.e.removal from farmland)under different agronomic practices is essential for understanding nutrient budgets and optimizing N and P fertilizer application in agroecosystems.It is not clear how plant N and P uptake and N:P stoichiometry vary between monoculture and intercropping throughout an entire growing season under different N fertilization and mulching practices.Here,we addressed how plant interspecific competition for nutrients have affected the temporal dynamics of crop N and P uptake(and N:P ratios)in five cropping systems(wheat,maize and barley monocultures,and wheat/maize and barley/maize intercropping),under two N levels(0 and 225 kg N ha^(−1))and two maize mulching treatments(with and without).Wheat and barley had greater N and P competitive ability than maize,leading to an increase in N and P uptake of wheat and barley and a decrease in N and P uptake of maize during co-growth stages in intercropping.N:P ratios of three crop species decreased with plant growth.Crop-level N:P ratios were either not affected by intercropping or did not change consistently with N fertilization while film mulching decreased maize N:P ratios.Community-level N:P ratios of the two intercrops were different from those of the corresponding monoculture at maturity.Because(i)the proportion of N and P removal from intercropping differs from monocultures,and(ii)N and P uptake by crops is decoupled under N fertilization and mulching,these findings may have practical implications for the nutrient budget of intercropping systems.